Relation between Level of Some Immunological Markers and Liver Functions with Respiratory Bacterial Infection in Sheep

Abstract

Sheep pneumonia remains an important cause of morbidity and mortality worldwide. The aim of the study report to determine Interleukine-6,IL-10,and liver function test , and kidney function test of sheep suffering from respiratory disease. Blood samples were collected from the diseased and healthy sheep during field study, for biochemical analysis. The results of 50 diseased animals were compared with results of 50 healthy animals.Data of selected biochemical parameters implicated a significant increase in Interleukin-6, alanine aminotransferase and aspartate aminotransferase, and Gamma glutamyltransferase in the diseased group compared to the healthy sheep's. On the other hand, a significant decrease was seen in the levels of IL-10, lactate dehydrogenase and total protein in the diseased group compared to the control. The results of this study could conclude that respiratory infections in sheep were associated with significant biochemical and immunological alterations which upon understanding can provide us with rapid diagnostic tools for pneumonia process in sheep and thus lead to better management and proper treatment.Future research is warranted to determine the response of individual animals to this disease and to describe the metabolic changes which occur during the course of respiratory diseases.