Relation between interleukin-6 level and subclinical intracranial large-artery atherosclerosis

Hoshi, Taku; Kitagawa, Kazuo; Yamagami, Hiroshi; Furukado, Shigetaka; Hougaku, Hidetaka; Hori, Masatsugu

doi:10.1016/j.atherosclerosis.2007.05.013

Cited by 28 publications

(19 citation statements)

References 27 publications

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“…52 Atherosclerosis lesion formation in different vascular beds may share common etiologic mechanisms. Increased levels of IL6 have been recently associated with intracranial large vessel atherosclerosis, 53 raising the possibility that the role of IL6 in atherogenesis may be similar in small and large vessels. IL6 is the principal regulator of acute-phase proteins and, therefore, plays a major role in the activation of the coagulation-fibrinolysis system.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain

Fornage

Chiang

O’Meara

et al. 2008

Stroke

163

106

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Background and Purpose-To clarify the role of inflammation in the pathogenesis of small vessel disease of the brain, we investigated the association between common variation in the C-reactive protein (CRP) and interleukin (IL)-6 genes, plasma CRP and IL6 levels, and presence of MRI-defined white matter lesions (WML) and brain infarcts (BI) in elderly participants of the Cardiovascular Health Study. Methods-Tag single nucleotide polymorphisms (SNPs) in the CRP and IL6 genes were selected from the SeattleSNPs database. In cross-sectional analyses, logistic regression models adjusting for known cardiovascular disease risk factors were constructed to assess the associations of plasma CRP and IL6 levels and common CRP and IL6 gene haplotypes with presence of WML or BI in Blacks (nϭ532) and Whites (nϭ2905). Results-Plasma IL6 and CRP levels were associated with presence of WML and BI in both races. In Whites, common haplotypes of the IL6 gene were significantly associated with WML and BI. The common haplotype tagged by the Ϫ174G/C promoter polymorphism was associated with an increased risk of WML (ORϭ1.14; 95% CI: [1.02; 1.28]). The common haplotype tagged by the Ϫ572G/C promoter polymorphism was associated with an increased risk of BI (ORϭ1.57; 95% CI: [1.15; 2.14]). Significant associations were lacking for WML or BI with IL6 gene variation in Blacks, or with CRP gene variation in either race. Conclusions-This study provides evidence of a genetic basis underlying the relationship between plasma biomarkers of inflammation and small vessel disease of the brain. Further studies to elucidate the specific role of IL6 in disease pathogenesis are warranted.

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Section: Discussionmentioning

confidence: 99%

Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain

Fornage

Chiang

O’Meara

et al. 2008

Stroke

163

106

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“…5 In particular, the levels of circulating inflammatory markers, such as high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and interleukin-18 (IL-18), could predict future risk of stroke and cardiovascular events. 6 -8 Several studies have demonstrated the association of inflammatory markers with the severity of vessel lesions in the carotid and intracranial arteries, 9,10 as well as with silent lacunar infarction (SLI) and white matter hyperintensities (WMH), 11,12 suggesting the involvement of inflammatory processes in SVD. Although a relationship between hsCRP, matrix metalloproteinase-9, and CMB was examined in acute stroke patients, 13 the relationship between CMB and inflammatory marker levels has not been investigated in individuals without a history of stroke.…”

mentioning

confidence: 99%

Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds

Miwa

Tanaka

Okazaki

et al. 2011

Stroke

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Background and Purpose-Cerebral microbleeds (CMB) are observed in the elderly and have been regarded as one of the manifestations of small vessel disease. Although inflammatory processes have attracted much attention not only in large-artery disease, but also in small vessel disease, their involvement in CMB remains to be determined. The purpose of this study is to clarify relations between inflammatory marker levels and CMB. Methods-Four hundred thirty-one patients without histories of cerebrovascular diseases were prospectively enrolled. The presence and number of CMB were assessed on gradient-echo magnetic resonance imaging. As common inflammatory markers, serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and interleukin-18 (IL-18) were evaluated. Results-CMB were found in 65 patients (15%). In 35 patients, at least one CMB was found in deep locations, but 30 patients had strictly lobar CMB. Levels of hsCRP, IL-6, and IL-18 were higher in patients with CMB than in those without. Logistic regression analyses showed that each 1SD increase in each inflammatory marker level was significantly associated with the presence of CMB after adjustment for age and sex, and after additional adjustment for cardiovascular risk factors, silent lacunar infarction, and white matter hyperintensity. The OR (95% CI) of hsCRP, IL-6, and IL-18 was 1.81 (1.35-2.46), 1.73 (1.18 -2.61), and 2.41 (1.44 -4.52), respectively. Furthermore, the inflammatory marker levels were associated with both deep and lobar CMB. Conclusions-Higher levels of hsCRP, IL-6, and IL-18 are associated with CMB, in both deep and lobar locations, suggesting the involvement of inflammation in CMB. (Stroke. 2011;42:3202-3206.)

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“…26 During the past 2 decades, increasing evidence has linked variations in the expression of inflammatory mediators, such as interleukin (IL)-6, IL-10, and 5-lipoxygenase, to stroke. [27][28][29][30][31][32] Atopic respiratory conditions have also been linked to similar changes in IL-6, IL-10, and 5-lipoxygenase. [33][34][35][36] Given these relationships, inflammation may be a critical link between atopic respiratory conditions and stroke.…”

Section: Discussionmentioning

confidence: 98%

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

Matheson¹,

Mainous²,

Carnemolla³

2009

The Journal of the American Board of Family Medicine

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Background: A history of atopic respiratory conditions has been linked to an increased risk of stroke. What remains unclear is whether positive allergy skin testing is associated with an increased risk of stroke. The primary goal of this study was to determine whether positive allergy skin testing is associated with an increased risk of fatal stroke. A secondary goal is to determine whether having both positive allergy skin testing and an atopic respiratory condition is associated with a particularly high risk of stroke death.Methods: An analysis was performed of the National Health and Nutrition Examination Survey II Mortality Cohort.Results: Controlling for age, gender, race, alcohol use, smoking status, diabetes, hypertension, and body mass index, patients with positive allergy skin testing had a hazard ratio for stroke mortality of 1.56 (95% CI, 1.01-2.40) versus those without positive allergy testing. Patients with both positive allergy testing and an atopic respiratory condition had a hazard ratio for stroke mortality of 2.31 (95% CI, 1.13-4.73).Conclusions: Individuals with both positive allergy skin testing and an atopic respiratory condition have more than a 2-fold increased risk of fatal stroke. This novel risk factor has substantial implications for a large segment of the population not previously considered at risk.

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Relation between interleukin-6 level and subclinical intracranial large-artery atherosclerosis

Cited by 28 publications

References 27 publications

Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain

Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain

Relations of Blood Inflammatory Marker Levels With Cerebral Microbleeds

The Association Between Allergy Skin Testing, Atopic Respiratory Conditions, and Stroke Mortality in Middle-Aged and Elderly Adults

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