Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23–25 kg/m<sup>2</sup>

Takeno, Kageumi; Tamura, Yasuaki; Kawaguchi, Minako; Kakehi, Saori; Watanabe, Takahiro; Fukushima, Takashi; Furukawa, Yasushi; Kaga, Hideyoshi; Yamamoto, Risako; Kim, Maeng-Kyu; Nishitani‐Yokoyama, Miho; Shimada, Kazunori; Daida, Hiroyuki; Aoki, Shigeki; Taka, Hikari; Fujimura, Tsutomu; Sawada, Susumu S.; Giacca, Adria; Kanazawa, Akio; Fujitani, Yoshio; Kawamori, Ryuzo; Watada, Hirotaka

doi:10.1210/jc.2016-1650

Cited by 54 publications

(126 citation statements)

References 41 publications

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“…However, these studies generally included type 2 diabetic patients with obesity and the role of visceral fat accumulation on hepatic insulin resistance in non-obese non-diabetic subjects may be different from those subjects. Indeed, our previous study showed that visceral fat area was negatively correlate to muscle insulin sensitivity, but not to hepatic insulin sensitivity in non-obese non-diabetic Japanese14. In addition, we found only a modest decrease in visceral fat area in the present study.…”

Section: Discussioncontrasting

confidence: 77%

“…By matching the record of alcohol intake of each subjects, for the first time, we found that alcohol consumption negatively correlated with hepatic insulin sensitivity, but not with muscle insulin sensitivity14. In addition, our preliminary multiple regression analysis revealed that only alcohol consumption was independently correlated with hepatic insulin sensitivity15.…”

mentioning

confidence: 65%

“…In addition, our preliminary multiple regression analysis revealed that only alcohol consumption was independently correlated with hepatic insulin sensitivity15. Given that our data also showed that impaired hepatic insulin sensitivity correlated positively with fasting plasma glucose (FPG) level14, alcohol intake may impair hepatic insulin sensitivity and increases FPG in non-obese non-diabetic Japanese. However, the causal relationship between these factors has not been investigated yet.…”

mentioning

confidence: 65%

“…Very recently, we applied two step hyperinsulinemic euglycemic clamp method with glucose tracer to accurately measure hepatic insulin sensitivity in non-obese non-diabetic Japanese and, for the first time, we found that alcohol consumption negatively correlated with hepatic insulin sensitivity, but not with muscle insulin sensitivity1415. To investigate the causal relationships, the present study evaluated the effects of 1-week alcohol abstinence on glucose metabolisms in 8 non-obese Japanese men with mildly elevated FPG.…”

Section: Discussionmentioning

confidence: 88%

“…Recently, we applied two step hyperinsulinemic (IIR = 10 and 20 mU/m 2 /min) euglycemic clamp study with glucose tracer to precisely evaluate hepatic insulin sensitivity in non-obese non-diabetic Japanese1415. By matching the record of alcohol intake of each subjects, for the first time, we found that alcohol consumption negatively correlated with hepatic insulin sensitivity, but not with muscle insulin sensitivity14.…”

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confidence: 97%

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Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Fukushima

Tamura

Takeno

et al. 2017

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It has been demonstrated that moderate alcohol consumption provides protection against the development of type 2 diabetes. However, several other reports suggested that moderate alcohol intake may increase the risk of type 2 diabetes in non-obese Japanese. The aim of present study was to investigate the effect of 1-week alcohol abstinence on hepatic insulin sensitivity and fasting plasma glucose (FPG) in non-obese Japanese men. We recruited 8 non-obese Japanese men with mildly elevated FPG and drinking habits alcohol (mean frequency; 5.6 ± 2.5 times/week, mean alcohol consumption; 32.1 ± 20.0 g/day). Before and after the 1-week alcohol abstinence, we used the 2-step hyperinsulinemic-euglycemic clamp to measure endogenous glucose production (EGP) and insulin sensitivity (IS) in muscle and liver. One-week alcohol abstinence significantly reduced both FPG by 7% (from 105.5 ± 11.7 to 98.2 ± 7.8 mg/dl, P < 0.01) and fasting EGP by 6% (from 84.1 ± 4.2 to 77.6 ± 1.6 mg/m2 per min, P < 0.01), respectively. Two–step clamp study showed that alcohol abstinence significantly improved hepatic-IS, but not muscle-IS. In conclusion, one week alcohol abstinence improved hepatic IS and FPG in non-obese Japanese men with mildly elevated FPG and drinking habits alcohol.

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confidence: 77%

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confidence: 65%

mentioning

confidence: 65%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 97%

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Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Fukushima

Tamura

Takeno

et al. 2017

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Characteristics of hepatic insulin‐sensitive nonalcoholic fatty liver disease

Shigiyama

Kumashiro

Furukawa

et al. 2017

Hepatology Communications

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Nonalcoholic fatty liver disease (NAFLD) plays a crucial role in type 2 diabetes and hepatocellular carcinoma. The major underlying pathogenesis is hepatic insulin resistance. The aim of the present study was to characterize patients with NAFLD with paradoxically normal hepatic insulin sensitivity relative to patients with NAFLD with hepatic insulin resistance. We recruited 26 patients with NAFLD and divided them into three groups ranked by the level of hepatic insulin sensitivity (HIS; high‐HIS, mid‐HIS, low‐HIS), as assessed by the hyperinsulinemic‐euglycemic clamp studies using stable isotope. Hepatic insulin sensitivity of the high‐HIS group was identical to that of the non‐NAFLD lean control (clamped percent suppression of endogenous glucose production, 91.1% ± 5.2% versus 91.0% ± 8.5%, respectively) and was significantly higher than that of the low‐HIS group (66.6% ± 7.5%; P < 0.01). Adiposity (subcutaneous, visceral, intrahepatic, and muscular lipid content), hepatic histopathology, and expression levels of various genes by using liver biopsies, muscle, and adipose tissue insulin sensitivity, plasma metabolites by metabolomics analysis, putative biomarkers, and lifestyles were assessed and compared between the high‐HIS and low‐HIS groups. Among these, adipose tissue insulin sensitivity assessed by clamped percent suppression of free fatty acid, serum high molecular weight adiponectin, and plasma tricarboxylic acid cycle metabolites, such as citric acid and cis‐aconitic acid, were significantly higher in the high‐HIS group compared to the low‐HIS group. In contrast, there were no differences in adiposity, including intrahepatic lipid content assessed by proton magnetic resonance spectroscopy (28.3% ± 16.1% versus 20.4% ± 9.9%, respectively), hepatic histopathology, other putative biomarkers, and lifestyles. Conclusion: High levels of adipose tissue insulin sensitivity, serum high molecular weight adiponectin, and plasma tricarboxylic acid cycle metabolites are unique characteristics that define patients with hepatic insulin‐sensitive NAFLD regardless of intrahepatic lipid content. (Hepatology Communications 2017;1:634–647)

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Physiological and Lifestyle Traits of Metabolic Dysfunction in the Absence of Obesity

et al. 2020

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Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23–25 kg/m²

Abstract: Among Japanese men with BMI of 23-25 kg/m, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.

Cited by 54 publications

References 41 publications

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Characteristics of hepatic insulin‐sensitive nonalcoholic fatty liver disease

Physiological and Lifestyle Traits of Metabolic Dysfunction in the Absence of Obesity

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Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23–25 kg/m2

Abstract: Among Japanese men with BMI of 23-25 kg/m, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.

Cited by 54 publications

References 41 publications

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study

Characteristics of hepatic insulin‐sensitive nonalcoholic fatty liver disease

Physiological and Lifestyle Traits of Metabolic Dysfunction in the Absence of Obesity

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Product

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Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23–25 kg/m²