Relation Between Indices Of Semen Analysis And Pregnancy Rate In Infertile Couples

Smith, Keith D.; Rodriguez‐Rigau, Luis J.; Steinberger, Emil

doi:10.1016/s0015-0282(16)42976-6

Cited by 173 publications

(44 citation statements)

References 12 publications

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“…Multiple semen sampling eliminated errors inherent in single-sample evaluation. The range, and mean semen volume, 0.4-10 ml and 2.56 ± 1.46, are fairly similar to those of fertile men according to various authors: e.g., 0.6-11 ml, 3.36 ± 1.84 by Sobreno and Rehan [8]; 0.1-12 ml, 2.51 ± 1.5 by Smith et al [5]; 0.4-7.5 ml, 2.83 ± 1.58 by Nelson and Bunge [2], and 0.1-11 ml, 3.2 ± 1.4 by Rehan et al [3], The mean sperm concentration of 7.38 ± 17.5 ob tained in this study is significantly lower statistically than 90 ± 71 and 47.8 ± 36 (p < 0.001) obtained by Macleod and Gold [1] and Smith et al [5] in a study of 1,000 and 198 husbands of infertile couples, respective ly. In fact the figures of these authors bear closer rela tionship with mean sperm densities of fertile men, e.g.…”

Section: Discussionsupporting

confidence: 86%

Semen Features of 596 Truly Infertile Men

Osegbe¹,

Amaku²

1987

Eur Urol

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Section: Discussionsupporting

confidence: 86%

Semen Features of 596 Truly Infertile Men

Osegbe¹,

Amaku²

1987

Eur Urol

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“…The low sperm concentration noted in 5% of semen samples from men classified as fertile because they had a pregnant partner conforms to what was published in the 1970s by David et al [8], Eliasson [7], MacLeod and Wang [9], Smith et al [10], Sobrero and Rehan [11], Zuckerman et al [12], van Zyl et al [13], and others. Maybe the lower reference limit presented by WHO together with these supporting references can finally overthrow the 20 million mL -1 paradigm.…”

Section: Number Of Spermatozoasupporting

confidence: 87%

Semen analysis with regard to sperm number, sperm morphology and functional aspects

Eliasson¹

2010

Asian J Androl

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The new World Health Organization (WHO) Manual for Semen Analysis contains several improvements. One is that the 20 million spermatozoa per mL paradigm has been ousted in favour of proper calculations of lower reference limits for semen from men, whose partners had a time-to-pregnancy of 12 months or less. The recommendation to grade the progressive motility as described in the third and fourth editions of the WHO manual was not evidence-based, and WHO was therefore motivated to abandon it. However, the new recommendation is not evidence-based either, and it is difficult to understand the rational for the new assessment. It may have been a compromise to avoid returning to the rather robust system recommended in the first edition (1980). The unconditional recommendation of the 'Tygerberg strict criteria' is not evidence-based, and seems to be the result of an unfortunate bias in the composition of the Committee in favour of individuals known to support the 'strict criteria' method. This recommendation will have negative effects on the development of andrology as a scientific field. Given the importance of the WHO manual, it is unfortunate that the recommendations for such important variables, as motility and morphology, lack evidence-based support.

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“…Although a semen analysis is the best predictive test we have to date, it clearly falls short of a true diagnosis (5,6). Indeed, several studies have shown that men with sperm numbers (7)(8)(9), morphology (8,10), and motility (11)(12)(13)(14)(15)(16)(17) below the thresholds outlined by the WHO can be fertile. Furthermore, there are many instances of men with normal sperm parameters that are infertile (13, 18 -20).…”

mentioning

confidence: 99%

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

Hetherington

Schneider‐Futschik

Scott

et al. 2016

Molecular & Cellular Proteomics

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Globally, ϳ1 in 15 men of reproductive age are infertile, yet the precise mechanisms underlying their gamete failure are unknown. Although a semen analysis is performed to determine fertilizing potential, the diagnostic suitability of this analysis has been questioned in several reports, as many men, classified as infertile according to their semen analysis, subsequently turn out to be fertile. Herein, we have used a quantitative (phospho)-proteomic analysis, using enrichment on titanium dioxide followed by ion-trap mass spectrometry (LC-MS/MS), to compare the semen of infertile versus fertile males. One protein, namely outer dense fiber 1 (ODF1), was dramatically reduced in infertile males. Using specific antibodies, we then screened the gametes of a cohort of suspected infertile men and demonstrated a reduction in the amount of ODF1 compared with fertile controls. Stress treatment of sperm deficient in ODF1 caused the head to decapitate, suggesting why these gametes fail to initiate fertilization. Interestingly, electron micrographs of ODF1-deficient spermatozoa revealed an abnormal connecting piece, indicating several developmental defects with both the implantation plate and the thin laminated fibers. In some cases, the implantation plate appeared to be reduced in size or was overburdened by granular material near the connecting piece. Hence, a strong reduction ODF1 is a marker of idiopathic male infertility and a potential driver of this condition. Molecular & Cellular Proteomics 15: 10.1074/ mcp.M116.060343, 3685-3693, 2016.Globally, in excess of 80 million people suffer from infertility (1), with ϳ1 in every seven couples so affected (2). In at least half of these cases, a defect in one or more aspects of sperm function appears to be the cause (2). Understanding the contribution of each partner to a couple's infertility is critical in determining how this situation can be optimally addressed. In the case of the male, a semen analysis focusing on sperm motility, concentration, and morphology is often performed to determine the fertilizing potential. A set of guidelines for evaluating semen quality was originally published by the World Health Organization (WHO) in 1980 (3). However, so inadequate were these criteria in predicting infertility that revised values had to be released in 1987, 1992, 1999, and again in 2010 (4). Although a semen analysis is the best predictive test we have to date, it clearly falls short of a true diagnosis (5, 6). Indeed, several studies have shown that men with sperm numbers (7-9), morphology (8, 10), and motility (11-17) below the thresholds outlined by the WHO can be fertile. Furthermore, there are many instances of men with normal sperm parameters that are infertile (13, 18 -20). Thus, these traditional diagnostic tests are limited in the information they generate and are poor predictors of male-factor infertility.In order to define the cause of male infertility, attempts have been made to identify changes in the proteomic composition of normal and infertile spermatozoa (20...

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Relation Between Indices Of Semen Analysis And Pregnancy Rate In Infertile Couples

Cited by 173 publications

References 12 publications

Semen Features of 596 Truly Infertile Men

Semen Features of 596 Truly Infertile Men

Semen analysis with regard to sperm number, sperm morphology and functional aspects

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility

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