Relation between hypertension and erectile dysfunction: a meta-analysisof cross-section studies

Abstract

Erectile dysfunction (ED) is a wide spread and troublesome problem in aging men. Many analyses of hypertensive patients suggest that the prevalence of ED in hypertensive populations is even higher. The purpose of this meta-analysis was to evaluate the relation between hypertension and ED. A literature review was performed to identify all cross-section studies about hypertension and erectile dysfunction. Sources included MEDLINE and EMBASE from 1966 to 2015. The reference lists of the retrieved studies were also investigated, and a meta-analysis were conducted. Eighteen cross-section studies involving a total of 41,943 participants and 10,151 cases of ED were used in this analysis. We found that risk of ED was increased with hypertension (summary OR = 1.84, 95% CI: 1.58-2.14, p < 0.000001). Adjusting for obesity, unfavorable lipid levels, alcohol abuse, physical activity, cigarette smoking, educational level and other lifestyle factors, hypertension was also associated with increased risk of ED (summary OR = 1.58, 95% CI: 1.35-1.86, p < 0.00001). The results of this meta-analysis support that hypertension is associated with an increased risk of ED. Further high-quality prospective studies are needed to confirm this observation.

Prevalence of Asymptomatic Coronary Artery Stenosis Based on Coronary Computed Tomography Angiography in Adults with Erectile Dysfunction: A Cross-Sectional Study

“…Binmoammar et al [24] reported that ED is an important predictor of asymptomatic CAD in type 2 diabetic patients. In addition, Wang et al [25] reported that hypertension was associated with increased risk of ED (summary OR = 1.58, 95% CI 1.35–1.86, p < 0.001). It is now recognized that ED is not a single disease but part of a syndrome that is related to other vascular diseases, especially cardiovascular disease [26].…”

“…This tendency was observed in this study as well. The association between ED and CAD is presumed to be due to the initial endothelial dysfunction and peripheral occlusive vessel changes in the common pathophysiologic mechanism [2, 25, 29]. Alternatively, ED is considered to be a precursor symptom observed before the manifestation of cardiovascular disease [30].…”

Developing a prediction model for the self‐evaluation of erectile dysfunction in an adult male population

“…In this study, the predictors included age, monthly income, BMI, educational level, smoking, chronic diseases, frequency of sexual intercourse, sexual desire, feelings about the spouse, masturbation and self-reported sexual satisfaction, all of which have been shown to affect the occurrence of ED (Ahn et al, 2007;Boddi et al, 2015;Fugl-Meyer et al, 2009;Martins & Abdo, 2010;Molina-Vega et al, 2019;Mulhall et al, 2016;Qin et al, 2012;Salonia et al, 2014;Wang et al, 2018). Accumulating studies have shown that general characteristics, including educational level, BMI, income, age, smoking and chronic diseases, are risk factors for ED (Ahn et al, 2007;Molina-Vega et al, 2019;Mulhall et al, 2016;Shin et al, 2011;Sun et al, 2006;Wang et al, 2018).…”

Alterations in the phosphodiesterase type 5 pathway and oxidative stress correlate with erectile function in spontaneously hypertensive rats

“…The risk factors for ED include ageing, psychiatric/psychological disorders, smoking, medications, hormonal factors and some chronic diseases like diabetes mellitus and hypertension 11,12 . It is well‐known that hypertension is an important worldwide health problem which is more common in elderly people and it can be an independent risk factor for ED 13,14 . CC is a part of the vascular system therefore ED is closely related to cardiovascular diseases such as hypertension.…”

“…11,12 It is well-known that hypertension is an important worldwide health problem which is more common in elderly people and it can be an independent risk factor for ED. 13,14 CC is a part of the vascular system therefore ED is closely related to cardiovascular diseases such as hypertension.…”