Relation Between HLA‐B27 and Clinical Features in Patients with Yersinia Arthritis

Laitinen, Ossi; Leirisalo, M; Skylv, Grethe

doi:10.1002/art.1780200512

Cited by 94 publications

(26 citation statements)

References 7 publications

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“…When intestinal symptoms were present, salmonella and yersinia infections (from 1969 on) were excluded by means of stool cultures and tests for agglutinating antibodies. Diagnosis of Chlamydia trachomatis infection, yersinia arthritis, and salmonella arthritis was made as described previously (10,(18)(19)(20).…”

mentioning

confidence: 99%

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Leirisalo

Skylv

Kousa

et al. 1982

Arthritis & Rheumatism

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212

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An analysis of 160 patients with Reiter's disease, 144 with yersinia arthritis, and 9 with salmonella arthritis was performed. Complete or incomplete Reiter's syndrome was observed in one‐third of the patients with yersinia arthritis and in most of those with salmonella arthritis. During the followup period, chronic back pain and joint symptoms were frequent in all the patient groups. Patients who were HLA—B27 positive had a more severe acute disease (more frequent back pain, urologic symptoms, mucocutaneous manifestations, and a longer duration of the disease) and more frequent chronic back pain and sacroiliitis.

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mentioning

confidence: 99%

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Leirisalo

Skylv

Kousa

et al. 1982

Arthritis & Rheumatism

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212

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“…One biologic implication of the finding in the present study is that the high responder HLA-B27 positive PMNs may contribute to a more prolonged disease (8,9), and to the occurrence of extraarticular inflammatory manifestations such as carditis and ocular symptoms (7,9, Table l), which are more common in yersinia arthritis patients with HLA-B27 than in those without Mowat (21) reported normal chemotaxis in ankylosing spondylitis and in acute Reiter's disease, both of which are known to be strongly associated with HLA-B27 (6). There are several explanations for the discrepancy between his results and ours.…”

Section: Discussionmentioning

confidence: 59%

“…Ten of the patients were restudArthritis and Rheumatism, Vol. 23,No. 9 (September 1980) ied several months later after their total recovery, three times by the agarose assay and once by the filter method.…”

Section: Methodsmentioning

confidence: 99%

“…HLA-B27 positive patients with reactive arthritis have a more prolonged disease (8,9) with more frequent extraarticular inflammatory manifestations (7,9) than do HLA-B27 negative patients. Polymorphonuclear leukocytes (PMNs) play an essential role in the inflammatory response by migrating to the site of tissue injury, ingesting foreign particles and damaged tissue components, and releasing lysosomal enzymes, thereby accelerating the inflammation.…”

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confidence: 99%

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Chemotaxis in yersinia arthritis HLA‐B27 positive neutrophils show high stimulated motility in vitro

Leirisalo¹,

Repo²,

Tiilikainen³

et al. 1980

Arthritis & Rheumatism

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MARJATTA LEIRISALO, HEIKKI REPO, ANJA TIILIKAINEN, T I M 0 U. KOSUNEN, and OSSI LAITINEN Chemotaxis, chemokinesis, and spontaneous locomotion of polymorphonuclear leukocytes (PMNs) of yersinia arthritis (YA) patients and healthy subjects with or without HLA-B27 were studied by agarose assay and membrane filter technique. HLA-B27 positive healthy control subjects and yersinia patients showed significantly higher response to chemotactic stimulus than HLA-B27 negative controls. Consequently, the high response was associated with HLA-B27 irrespective of YA. The high responder PMNs may contribute to the more severe inflammatory symptoms in YA patients with HLA-B27.Reactive arthritis is a form of nonpurulent arthritis following an infection elsewhere in the body. In addition to rheumatic fever, a sequel of streptococcal pharyngitis, reactive arthritis can follow some enteric or urogenital infections such as Yersiniu enterocoliticu (I), salmonella (2), shigella (3), chlamydia (4), or cam-~

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“…The development of arthritis is mostly determined by genetic susceptibility. Approximately 90% of these patients present the HLA-B27 antigen (2).…”

Section: Introductionmentioning

confidence: 99%

Association between polyclonal B cell activation and the presence of autoantibodies in mice infected with Yersinia enterocolitica O:3

Medeiros¹,

Costa²,

Araujo³

et al. 1997

Braz J Med Biol Res

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Eight-week old conventional female Swiss mice were inoculated intravenously with Yersinia enterocolitica O:3. A second group of normal mice was used as control. Five mice from each group were bled by heart puncture and their spleens were removed for spleen cell collection on the 3rd, 5th, 7th, 10th, 14th and 21st day after infection. Immunoglobulin-secreting spleen cells were detected by the isotypespecific protein A plaque assay. Total immunoglobulin levels were determined in mouse serum by single radial immunodiffusion and the presence of autoantibodies was determined by ELISA. We observed a marked increase in the total number of cells secreting immunoglobulins of all isotypes as early as on the 3rd day post-infection and the peak of secretion occurred on the 7th day. At the peak of the immunoglobulin response, the total number of secreting cells was 19 times higher than that of control mice and most immunoglobulin-secreting cells were of the IgG 2a isotype. On the 10th day post-infection, total serum immunoglobulin values were 2 times higher in infected animals when compared to the control group, and continued at this level up to the 21st day post-infection. Serum absorption with viable Y. enterocolitica cells had little effect on antibody levels detected by single radial immunodiffusion. Analysis of serum autoantibody levels revealed that Y. enterocolitica infection induced an increase of antimyosin and anti-myelin immunoglobulins. The sera did not react with collagen. The present study demonstrates that Y. enterocolitica O:3 infection induces polyclonal activation of murine B cells which is correlated with the activation of some autoreactive lymphocyte clones.

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Relation Between HLA‐B27 and Clinical Features in Patients with Yersinia Arthritis

Cited by 94 publications

References 7 publications

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Followup study on patients with reiter's disease and reactive arthritis, with special reference to HLA—B27

Chemotaxis in yersinia arthritis HLA‐B27 positive neutrophils show high stimulated motility in vitro

Association between polyclonal B cell activation and the presence of autoantibodies in mice infected with Yersinia enterocolitica O:3

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