Relation between Green Tea Consumption and the Severity of Coronary Atherosclerosis among Japanese Men and Women

Sasazuki, Shizuka; Kodama, Hiroko; Yoshimasu, Kouichi; Liu, Ying; Washio, Masakazu; Tanaka, Keitaro; Shoji, Tetsuo; Kono, Suminori; Arai, Hidekazu; Doi, Yoshiko; Kawano, Teruaki; Nakagaki, Osamu; Takada, Kazuyuki; Koyanagi, Samon; Hiyamuta, Kohji; Nii, Takenobu; Shirai, Kohji; Ideishi, Munehito; Arakawa, Kikuo; Mohri, Masahiro; Takeshita, Akira

doi:10.1016/s1047-2797(00)00066-1

Cited by 116 publications

(70 citation statements)

References 31 publications

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“…For example, the two existing studies on green tea and stroke have both shown protective effects (104,105) . In addition, tea consumption has been inversely associated with precursors of CVD including atherosclerosis (101,106) and hypertension (107)(108)(109) .…”

Section: Cancersmentioning

confidence: 99%

Tea or coffee? A case study on evidence for dietary advice

Binns

Lee

Fraser

2008

Public Health Nutr.

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The present paper explores the level of evidence required to justify giving dietary advice to the public. There are important practical differences between the development of public health nutrition guidelines and guidelines for clinical practice. While the gold standard for evidence for clinical practice guidelines is a meta-analysis of a number of randomised controlled trials, this is often unrealistic and sometimes unethical for the evaluation of public health nutrition interventions. Hence, epidemiological studies make up the bulk of evidence for nutrition guidelines. Tea and coffee are an interesting case study in relation to this issue. They are two of the most commonly consumed beverages worldwide, yet there is little dietary advice on their use. The evidence for a relationship between coffee or tea consumption and several diseases is discussed. The available studies, predominantly epidemiological, together with animal and in vitro studies, indicate that coffee and tea are both safe beverages. However, tea is the healthier option because it has a possible role in the prevention of several cancers and CVD. While the evidence for such relationships is not strong, the public will continue to drink both tea and coffee, and will continue to ask nutritionists to make recommendations. It is therefore argued that advice should be given on the best available data, as waiting for complete data to become available could have severe consequences for public health.

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Section: Cancersmentioning

confidence: 99%

Tea or coffee? A case study on evidence for dietary advice

Binns

Lee

Fraser

2008

Public Health Nutr.

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“…The odds ratio of significant coronary stenosis for consumption of 4 or more cups per day was 0.4 (95% confidence interval 0.2-0.9), respectively, as compared with a consumption of one cup per day or less. 20 Notably, this association was not observed in females. In a previous study green tea consumption did not differ among patients with or without coronary artery disease.…”

Section: Green Tea Consumption and Coronary Artery Diseasementioning

confidence: 86%

Role of green tea in reduction of cardiovascular risk factors

Alexopoulos¹,

Vlachopoulos²,

Stefanadis³

2010

NDS

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Tea is widely consumed worldwide. There is accumulating evidence that tea consumption may be associated with reduced cardiovascular risk, an association that could be attributed to its flavonoid content. Green tea, the most common type of tea consumed in Asia, contains a large amount of nonoxidized flavonoids, named catechins. Green tea consumption has been associated with reduced incidence of cardiovascular mortality, stroke, and myocardial infarction. Although there is some inconsistency in the results, large, well-designed observational studies have shown this inverse association. However, the association of green tea with coronary artery disease is less well-established. The protective effect of green tea on cardiovascular events may be mediated by beneficial effects of green tea on various classical and novel cardiovascular risk factors. There is evidence that green tea reduces total and low-density lipoprotein (LDL) cholesterol and oxidized LDL cholesterol, enhances insulin sensitivity, and may prevent development of diabetes mellitus. There is also evidence that green tea reduces oxidative stress and reverses endothelial dysfunction. Its effect on blood pressure and arterial stiffness is confounded by the presence of caffeine, which has pressor and arterial stiffening effects, although this effect is probably counterbalanced by beneficial effects of other constituents in green tea. Green tea acutely increases blood pressure more than its caffeine content; the ingredients responsible for this are not known. On the other hand, green tea has a milder acute effect on arterial stiffness than its caffeine content. Its chronic effect on blood pressure and arterial stiffness may be neutral or even beneficial.

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“…Indeed, a recent study in humans suggested that green tea may contribute to reductions in the risk of type 2 diabetes and CVD (14). In a cross-sectional study, an inverse association between green tea consumption and coronary atherosclerosis was observed in 512 Japanese subjects undergoing coronary angiography (32). In a cohort study on green tea consumption, it was found that the risk of significant stenosis was lower by 50% in subjects consuming 2-3 cups per day and by 60% for those consuming 4 cups per day, compared with those consuming 1 cup per day in a subgroup of 262 men without dietary or drug treatments for type 2 diabetes (32).…”

Section: Discussionmentioning

confidence: 99%

“…In a cross-sectional study, an inverse association between green tea consumption and coronary atherosclerosis was observed in 512 Japanese subjects undergoing coronary angiography (32). In a cohort study on green tea consumption, it was found that the risk of significant stenosis was lower by 50% in subjects consuming 2-3 cups per day and by 60% for those consuming 4 cups per day, compared with those consuming 1 cup per day in a subgroup of 262 men without dietary or drug treatments for type 2 diabetes (32). In addition, a retrospective cohort study among 17,413 Japanese adult subjects found a 33% reduction in the risk of developing type 2 diabetes in subjects consuming 6 cups of green tea per day, compared with those consuming ,1 cup per week (33).…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation with a Low Dose of (^|^minus;)-Epigallocatechin-3-Gallate Reduces Pro-Inflammatory Responses in Peripheral Leukocytes of Non-Obese Type 2 Diabetic GK Rats

Uchiyama

Suzuki

Mochizuki

et al. 2013

J Nutr Sci Vitaminol

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Summary (2)-Epigallocatechin-3-gallate (EGCG), which is largely found in green tea, is known to eliminate reactive oxygen species and associated inflammatory responses in vitro and in cells. However, the in vivo mechanisms underlying the effects of EGCG on the amelioration of metabolic disorders are not fully understood. In this study, we examined whether dietary supplementation with EGCG reduces inflammatory responses in peripheral leukocytes of a non-obese type 2 diabetes animal model, Goto-Kakizaki (GK) rats. GK rats at 9 wk of age were fed a control high-fat diet (46 energy % from lard and corn oil) or a high-fat diet containing 0.1%, 0.2%, or 0.5% EGCG (w/w) for 25 wk. The oxidative stress markers 8-hydroxydeoxyguanosine (OHdG) and total malondialdehyde (MDA) were reduced by supplementation with EGCG at 0.1%, but not at 0.2% or more. Significant reductions in the mRNA levels of genes related to inflammatory responses (TNF-a, IFN-g, IL-1b, IL-6, IL-18, MCP-1, CD11b, and S100a6), 8-OHdG, and total MDA were induced in peripheral leukocytes of GK rats by EGCG supplementation at 0.1%, but not at 0.2% or more, compared with rats fed the control diet. The present results suggest that supplementation with a low dose of EGCG reduces oxidative stress and the expressions of genes involved in inflammation in peripheral leukocytes of GK rats.

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Relation between Green Tea Consumption and the Severity of Coronary Atherosclerosis among Japanese Men and Women

Cited by 116 publications

References 31 publications

Tea or coffee? A case study on evidence for dietary advice

Tea or coffee? A case study on evidence for dietary advice

Role of green tea in reduction of cardiovascular risk factors

Dietary Supplementation with a Low Dose of (^|^minus;)-Epigallocatechin-3-Gallate Reduces Pro-Inflammatory Responses in Peripheral Leukocytes of Non-Obese Type 2 Diabetic GK Rats

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