Relation between extent of coronary artery disease and severity of hyperlipoproteinaemia.

Abstract

Lipoprotein analyses were performed in 133 male patients and were correlated with the coronary arteriographic findings. The prevalence of hyperlipoproteinaemia was significantly higher in those patients with coronary artery disease (P < 0 01). In addition, the more extensive the degree of coronary artery pathology the higher were the plasma concentrations of total cholesterol, tiglyceride, and low density lipoprotein (LDL) cholesterol. Hyperlipoproteinaemia was more prevalent in the younger patients with coronary artery disease (P < 0 02).There is epidemiological evidence to support the? In addition, the importance of hyperlipoproteinassociation between coronary heart disease and aemia in relation to the age of patients presenting hyperlipoproteinaemia (Kannel et al., 1971; Carlson with coronary artenral disease has been assessed. and Bottiger, 1972). Selective coronary arteriography has provided a means of assessing the degree of coronary atherosclerosis (Kemp et al., Patients and methods (Judkins, 1967; disease (Banks, Raftery, and Oram, 1971; Barboriak Sones and Shirey, 1962 , 1973). Similarly, an association between circumflex coronary arteries). The patients were raised triglyceride concentration and coronary accordingly classified as having either a normal vasculaarterial disease has been reported (Salel et al., 1974), ture or single, double, or triple vessel disease. but the relation between the extent of vessel disease Lipoprotein typing was carried out on two venous and triglyceride levels remains in dispute (Cram6r blood samples (35 ml) drawn after a minimum 12-hour, et al., 1966;Heinle et al., 1969; Nitter-Hauge and overnight fast. Plasma total cholesterol (Annan and Enge, 1973;Barboriak et al., 1974). Isherwood, 1969) and triglyceride (Kessler and Lederer, Enge, 197;) concentrations were measured. Lipoprotein The purpose of this study was to assess the electrophoresis was carried out using polyacrylamide gel lipoprotein profile in patients having selective (Narayan, Narayan, and Kummerow, 1965). In 51 coronary arteriography for the diagnosis of chest patients (36%) 5 ml of plasma was spun for 16 hours at was precipitated from the bottom fraction by heparin/ 1967

Heart Rate Variability ? A Historical Perspective

“…The term “HRV” yields nearly 14,000 “hits” when placed in the pubmed search engine. A variety of cardiovascular risk factors and disease states have all been shown to reduce HRV, including diabetes (Murray et al, 1975; Ewing et al, 1985; Vinik et al, 2003; Rosengard-Barlund et al, 2009), smoking (Mancia et al, 1997; Karakaya et al, 2007), obesity (Skrapari et al, 2007), Work stress (Thayler et al, 2010), hypertension (Pagani et al, 1984; Pagani and Lucini, 2001; Maule et al, 2008), and heart failure (Saul et al, 1988; Binkley et al, 1991; Woo et al, 1994; Adamopoulos et al, 1995; Kiilavuori et al, 1995; De Jong and Randall, 2005). …”

“…Fetal heart rate monitoring has now become the standard of care and has contributed to reductions in morbidity associated with fetal distress. In the 1970s, Ewing and co-workers used short-term changes in R–R interval in response to simple autonomic challenges to detect autonomic neuropathy in diabetic patients (Murray et al, 1975; Ewing et al, 1985). …”

Increased Plasma Fibrinogen and Platelet-Aggregates in Type II Hyperlipoproteinaemia

“…Venous samples were taken between 9 and 11 a.m. Plasma lipids (total cholesterol; very low density, low density, and high density lipoprotein cholesterol; and triglyceride) were measured after a 12 hr fast, as previously described (Murray et al 1975). Table 1 shows that the patients with hyperlipoproteinaemia were of comparable age to the controls, and had higher mean levels of total cholesterol and triglyceride (p<0.01, Wilcoxon rank-sum test).…”

Diet, heredity and heart disease

“…close association between plasma cholesterol levels and the risk of CHD (Kannel, Dauber, Friedman, Glennon & McNamara, 1964;Keys, 1970;Carlson & Bottiger, 1972 The possible relationship between hyperlipidaemia or more specifically hyperlipoproteinaemia and CHD was investigated by us using the technique of selective coronary angiography. A study comparing lipoprotein patterns with the coronary angiographic findings in 133 male patients who presented with symptoms suggestive of coronary heart disease was carried out (Murray, Tweddel, Third, Hutton, Hillis, Lorimer & Lawrie, 1975). Significant coronary artery disease (CAD) was considered to be present when the lumen of any of the three major coronary arteries was occluded by at least 5070.…”