Relation between estrogen receptor concentration and clinical and histological factors: Their relative prognostic importance after radical mastectomy for primary breast cancer

Andry, Guy; Suciu, Stefan; Pratola, Danilo; Sylvester, Richard; Leclercq, Guy; Costa, Pierre Mendes Da; Legros, Nicole; M, Andry-t'Hooft; Verhest, Alain; Mattheiem, Wolrad; Heuson, Jean-Claude

doi:10.1016/0277-5379(89)90025-4

Cited by 29 publications

(13 citation statements)

References 49 publications

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“…operable breast cancer whereas the traditional markers of tumour size and nodal status remained so. These observations are similar to those of other recent studies (Andry et al, 1989;Spyratos et al, 1989) as is the observation that prognostic significance recedes with time (Howell et al, 1984;Hahnel et al, 1979;Howat et al, 1983;Andry et al, 1989;Spyratos et al, 1989). These results contrast with the findings of our own earlier observations and those of other workers, particularly in the inability of receptor status to separate out a group of poor risk node negative patients.…”

Section: Discussioncontrasting

confidence: 57%

“…Although some studies found that both disease free interval and overall prognosis were prolonged in receptor positive patients (Bishop et al, 1979;Osborne et al, 1980;Rich et al, 1978) others only noted an improvement in post-relapse survival (Hahnel et al, 1979;Hilf et al, 1980;Howell et al, 1984) and concluded that receptor status had only identified which patients were most likely to benefit from hormonal manipulation (Howell et al, 1984;Andry et al, 1989;Howat et al, 1985). Finally, other reports found improved survival only in certain sub-groups of patients, such as post-menopausal women or patients with axillary nodal involvement (Vollenweider-Zerargui et al, 1986;Bishop et al, 1979;Kinne et al, 1981 Figures 1 and 2 illustrate the relationship of oestrogen receptor status to survival, both individually and also stratified by nodal status.…”

mentioning

confidence: 99%

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The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast

Winstanley

Cooke²,

George³

et al. 1991

Br J Cancer

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Oestrogen receptors were one of the first molecular markers of prognosis to be described in breast cancer and 10 years ago we reported our experience of their significance in predicting early recurrence of disease following surgical treatment (Cooke et al., 1979). In that study we found the presence of oestrogen receptors to be associated with both longer disease free interval and overall survival. Although our results were similar to those of several other studies (Knight et al., 1977;Allegra et al., 1979;Westerberg et al., 1980;Gapinski et al., 1980), the finding in. some later studies were inconsistent and areas of controversy have arisen. A minority of investigators failed to find any survival advantage for oestrogen receptor positive patients (Hilf et al., 1980;Alanko et al., 1984;Parl et al., 1984). In those studies in which a survival advantage has been reported for patients with oestrogen receptor positive tumours three broad areas of disagreement have emerged. These have related to the duration of time over which oestrogen receptors exert any beneficial effect, the sub-groups of patients benefiting and whether the apparently longer survival of oestrogen receptor positive patients was due to a prolonged disease free survival or longer post recurrence survival.As studies with longer follow-up than in the initial reports appeared the apparent improvement in survival amongst receptor positive patients in some studies was only present for a limited period, thereafter the survival of the two groups being similar (Raemaekers et al., 1985;Von Maillot et al., 1982;Hahnel et al., 1979; Howat et al., 1983). Although some studies found that both disease free interval and overall prognosis were prolonged in receptor positive patients (Bishop et al., 1979;Osborne et al., 1980;Rich et al., 1978) others only noted an improvement in post-relapse survival (Hahnel et al., 1979; Hilf et al., 1980; Howell et al., 1984)

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Section: Discussioncontrasting

confidence: 57%

mentioning

confidence: 99%

The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast

Winstanley

Cooke²,

George³

et al. 1991

Br J Cancer

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“…It is well documented that ER-negative tumours grow more aggressively and tend to metastasise more than ER-positive tumours (Andry et al, 1989;Winstanley et al, 1991). It is possible that hK10, a serine protease, may be associated with aggressiveness and metastatic potential of tumour cells.…”

Section: Discussionmentioning

confidence: 99%

Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance

et al. 2002

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The human tissue kallikreins are secreted serine proteases, encoded by a group of homologous genes clustered in tandem on chromosome 19q13.3-4. Human kallikrein 6 and human kallikrein 10 are two new members of this family. Recently, we developed highly sensitive and specific immunofluorometric assays for human kallikrein 6 and human kallikrein 10, which allow for their quantification in tissue extracts and biological fluids. Both human kallikrein 6 and human kallikrein 10 are found to be down-regulated in breast cancer cell lines, suggesting that they may be involved in breast cancer pathogenesis and progression. In this study, we investigated the potential value of human kallikrein 6 and human kallikrein 10 as prognostic and predictive factors in breast cancer. We quantified human kallikrein 6 and human kallikrein 10 protein levels in 749 breast tumour cytosolic extracts and correlated this data with various clinicopathological variables and patient outcomes. Human kallikrein 6 and human kallikrein 10 are positively correlated with each other. Higher human kallikrein 6 and human kallikrein 10 protein levels are associated with younger age, pre-menopausal, status and tumours which are negative for oestrogen and progesterone receptors. No correlation was found between human kallikrein 6 and human kallikrein 10 levels and tumour size, grade, and nodal status. Survival analysis showed that neither human kallikrein 6 nor human kallikrein 10 are related to the rate of relapse-free and overall survival. In the analysis with respect to response to tamoxifen therapy, although human kallikrein 6 levels were not associated with tamoxifen responsiveness, higher levels of human kallikrein 10 were significantly associated with a poor response rate. This association remained significant in the multivariate analysis. Furthermore, higher human kallikrein 10 levels were significantly related with a short progression-free and post-relapse overall survival after start of tamoxifen treatment for advanced disease. Taken together, our results suggest that although human kallikrein 6 and human kallikrein 10 are not prognostic markers for breast cancer, human kallikrein 10 is an independent predictive marker for response of tamoxifen therapy.

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“…Because ER-negative tumor cells are less differentiated and more aggressive (15,36,37), a selection of ER-negative cells during the development of metastases might produce lower ER levels in metastatic lesions (33). On the other hand, more ERs in metastatic lymph nodes may result from different histologic patterns.…”

Section: Methodsmentioning

confidence: 99%

“…Assuming that the overall proportion of methylated ER genes is similar to that of ER-negative status amofig African-American patients (42%) [36], we will have 152 and 210 cases with methylated and unmethylated ER genes. An equal number (n=362) of controls will be selected.…”

Section: Sample Size and Study Powermentioning

confidence: 99%

Cancer Prevention and Control Research Manpower Development

Shacks¹

1997

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sourceo, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information including suggestions for reducing this burden, to Washington Headquarters Services, Directorate ABSTRACT (Maximum 200The primary aim of this project in year two was to complete the recruitment of six post-doctoral graduates. Where copyrighted material is quoted, permission has been a • ned to use such material.Where material from documents designated for limited stribution is quoted, permission has been obtained to use the t rial.Citations of commercial organizations and trade names in report do not constitute an official Department of Army endorsement or approval of the products or services of these organizations.In conducting research using animals, the investigator(s) adhered to the "Guide for the Care and Use of Laboratory Animals," prepared by the Committee on Care and use of Laboratory Animals of the Institute of Laboratory Resources, National Research Council (NIH Publication No. 86-23, Revised 1985).For the protection of human subjects, the investigator(s) adhered to policies of applicable Federal Law 45 CFR 46.In conducting research utilizing recombinant DNA technology, the investigator(s) adhered to current guidelines promulgated by the National Institutes of Health.In the conduct of research utilizing recombinant DNA, the investigator(s) adhered to the NIH Guidelines for Research Involving Recombinant DNA Molecules.In the conduct of research involving hazardous organisms, .the investigator(s) adhered to the CDC-NIH Guide for Biosafety in Microbiological and Biomedical Laboratories. IntroductionBreast cancer is a leading cause of death in American women. Women of minority groups have higher mortality rates for this disease compared to white women. To address this issue, efforts to increase minority representation in cancer research have been made by the National Institute of Medicine. Success of these activities have been limited, and the pool of minority investigators remains small. The purpose of this project is to expand the pool of minority cancer control and prevention investigators. The overall aim of this three year study is to provide training in breast cancer prevention and control research for six post-doctoral graduates. The ultimate goal is to create WU independent investigators who will obtain extramural funding upon completion of the fellowship. The hypotheses to be tested is that with "protected time" and appropriate mentors doctoral graduates in C social science and public health disciplines can achieve independent extramural funding for breast F cancer research within three years. Fellows are paired with faculty mentors from one of three Cancer Centers; Drew University of Medicine and Science in Los Ang...

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Relation between estrogen receptor concentration and clinical and histological factors: Their relative prognostic importance after radical mastectomy for primary breast cancer

Cited by 29 publications

References 49 publications

The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast

The long term prognostic significance of oestrogen receptor analysis in early carcinoma of the breast

Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance

Cancer Prevention and Control Research Manpower Development

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