Relation between drug treatment and cancer In hypertenslves in the Swedish Trial in Old Patients with Hypertension 2: a 5-year, prospective, randomised, controlled trial

Lindholm, Lars; Anderson, Harald; Ekbom, Tord; Hansson, Lennart; Lanke, Jan; Dahlöf, Björn; Fairé, Ulf dé; Forsén, Kent; Hedner, Thomas; Linjer, Erland; Scherstén, Bengt; Wester, Per‐Olov; Möller, Torgil

doi:10.1016/s0140-6736(01)05704-x

Cited by 103 publications

(85 citation statements)

References 25 publications

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“…1,5,18 As in our study, a recent study among Swedish hypertensive patients found theory overall risk of cancer to be the same as that in the general population. 28 In this study, the incidence of kidney cancer was also increased in both sexes (RR 1.4), but this was statistically nonsignificant (95% CI 0.85-2.1). They found no significant increase or decrease in the incidence of cancers of the endometrium, pancreas, lung, liver or any other site.…”

Section: Discussioncontrasting

confidence: 58%

Cancer pattern among hypertensive patients in North Karelia, Finland

et al. 2005

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The objective of this study was to determine the sitespecific cancer incidence of hypertensive patients and examine the effect of blood pressure-related variables on the risk of cancers with elevated incidence among the hypertensive patients. A record linkage study of Hypertension Register of the North Karelia Project and the Finnish Cancer Registry was conducted. The mean follow-up time was 16 years. A total of 20 529 hypertensive patients were studied. Main outcome measures were standardised incidence ratios and hazard ratios. The overall cancer incidence was close to that of the general population for both men and women. The incidence rate for the kidney cancer was significantly increased in hypertensive patients (standardised incidence ratio 1.34, 95% confidence interval (CI) 1.11-1.60), as well as incidence rates for cancers of pancreas (1.26, 1.02-1.54), and endometrium (1.22, 1.01-1.44) in hypertensive women. The incidence of lung cancer was significantly decreased (0.86, 0.77-0.95). The incidence of liver cancer was elevated with borderline significance (1.36, 0.99-1.82). In Cox regression models, the use of antihypertensive drugs at baseline was a significant predictor of kidney (hazard ratio for use of antihypertensive drugs 1.89, 95% CI 0.96-3.75) and pancreatic cancer (1.78, 0.99-3.22) in women but not in men. The incidence of endometrial cancer or liver cancer was not related to blood pressure levels or the use of antihypertensive drugs. In women, obesity was a significant predictor of cancers of the endometrium, kidney and liver. In conclusion, increased occurrence of some cancer types among hypertensive patients seem to be partly explained by obesity and the use of antihypertensive drugs.

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Section: Discussioncontrasting

confidence: 58%

Cancer pattern among hypertensive patients in North Karelia, Finland

et al. 2005

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“…The STOP-Hypertension-2 Study also provided valuable information on the incidence of cancer during antihypertensive therapy, since the availability of a comprehensive cancer registry in Sweden made it possible to compare the incidence of new cancers during the study with that expected in the general Swedish population. 11 This is an important issue in view of the controversial reports of an association between calcium antagonists and cancer. 12,13 Reassuringly, the STOP-Hypertension-2 data provided no evidence of any such association.…”

Section: Figurementioning

confidence: 99%

The problem of uncontrolled hypertension

Lindholm

2002

J Hum Hypertens

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“…Frequency did not differ significantly between patients randomly assigned to conventional drugs, calcium antagonists, or ACEis. 57 Another population-based case-control study conducted in western Washington State included 975 women aged 65-79 years who were diagnosed with invasive breast carcinoma during 1997-1999. It found that there was no difference in the risk of breast carcinoma related to use of antihypertensive medications.…”

Section: Clinical Observationsmentioning

confidence: 99%

Angiotensin inhibition and malignancies: a review

Rosenthal

Gavras

2009

J Hum Hypertens

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After an early report that patients treated with angiotensin-converting enzyme (ACE) inhibitors had a lower than expected incidence of cancers, there was a large number of publications investigating the possible pathophysiological mechanism mediating this effect, as well as population studies comparing the incidence of cancers in patients treated with agents inhibiting the reninangiotensin system with their incidence in the general population. Several mechanisms are proposed to explain a potential anti-tumour activity of such agents in vitro in experimental animal models. However, the population studies are mostly inconclusive, although they do suggest a possible interaction between ACE genotypes and susceptibility to altered behaviour of certain tumours.

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Relation between drug treatment and cancer In hypertenslves in the Swedish Trial in Old Patients with Hypertension 2: a 5-year, prospective, randomised, controlled trial

Cited by 103 publications

References 25 publications

Cancer pattern among hypertensive patients in North Karelia, Finland

Cancer pattern among hypertensive patients in North Karelia, Finland

The problem of uncontrolled hypertension

Angiotensin inhibition and malignancies: a review

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