Relation between DIR recalculated dose based CBCT and GI and GU toxicity in postoperative prostate cancer patients treated with VMAT

Buranaporn, Panyapat; Dankulchai, Pittaya; Jaikuna, Tanwiwat; Prasartseree, Tissana

doi:10.1016/j.radonc.2020.12.036

Cited by 8 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we had implemented two ways to improve the quality of CBCT images, including the registration of pCT to CBCT and the generation of sCT from CBCT. There existed many studies on CBCT-based dose calculations and CBCT-guided adaptive radiotherapy, which demonstrated that registration and sCT generation were acceptable within error tolerances ( 33 – 38 ). However, few studies had compared the accuracy difference of registration and sCT generation when the anatomical structure changes in pCT and CBCT scans.…”

Section: Discussionmentioning

confidence: 99%

A Comparison Study Between CNN-Based Deformed Planning CT and CycleGAN-Based Synthetic CT Methods for Improving iCBCT Image Quality

Yang

Chang²,

Liang³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

PurposeThe aim of this study is to compare two methods for improving the image quality of the Varian Halcyon cone-beam CT (iCBCT) system through the deformed planning CT (dpCT) based on the convolutional neural network (CNN) and the synthetic CT (sCT) generation based on the cycle-consistent generative adversarial network (CycleGAN).MethodsA total of 190 paired pelvic CT and iCBCT image datasets were included in the study, out of which 150 were used for model training and the remaining 40 were used for model testing. For the registration network, we proposed a 3D multi-stage registration network (MSnet) to deform planning CT images to agree with iCBCT images, and the contours from CT images were propagated to the corresponding iCBCT images through a deformation matrix. The overlap between the deformed contours (dpCT) and the fixed contours (iCBCT) was calculated for purposes of evaluating the registration accuracy. For the sCT generation, we trained the 2D CycleGAN using the deformation-registered CT-iCBCT slicers and generated the sCT with corresponding iCBCT image data. Then, on sCT images, physicians re-delineated the contours that were compared with contours of manually delineated iCBCT images. The organs for contour comparison included the bladder, spinal cord, femoral head left, femoral head right, and bone marrow. The dice similarity coefficient (DSC) was used to evaluate the accuracy of registration and the accuracy of sCT generation.ResultsThe DSC values of the registration and sCT generation were found to be 0.769 and 0.884 for the bladder (p < 0.05), 0.765 and 0.850 for the spinal cord (p < 0.05), 0.918 and 0.923 for the femoral head left (p > 0.05), 0.916 and 0.921 for the femoral head right (p > 0.05), and 0.878 and 0.916 for the bone marrow (p < 0.05), respectively. When the bladder volume difference in planning CT and iCBCT scans was more than double, the accuracy of sCT generation was significantly better than that of registration (DSC of bladder: 0.859 vs. 0.596, p < 0.05).ConclusionThe registration and sCT generation could both improve the iCBCT image quality effectively, and the sCT generation could achieve higher accuracy when the difference in planning CT and iCBCT was large.

show abstract

Section: Discussionmentioning

confidence: 99%

A Comparison Study Between CNN-Based Deformed Planning CT and CycleGAN-Based Synthetic CT Methods for Improving iCBCT Image Quality

Yang

Chang²,

Liang³

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…In recent years, more and more off-line adaptive methods have been used for dosimetric and robustness evaluation. In 2021, Buranaporn [4] studied the relationship between dose-received volume and complications of OARs during radiotherapy for bladder cancer, and the applied method was the fusion of CBCT and PCT using DIR for off-line adaptive radiotherapy. Tamihardja's [21] study also used CBCT-based off-line adaptive radiotherapy to assess the difference between actual dose and planned dose in prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, some dose-related toxicity to the organs at risk (OARs) is inevitable during pelvic radiotherapy, especially for the bladder and the small intestine [3] . At present, some methods are available to reduce the dose toxicity of OARs, such as the use of intensity-modulated radiotherapy (IMRT) or volume-modulated arc therapy (VMAT) optimization, and the use of the prone position to reduce the irradiated volume of OARs [4] . However, to make full use of these techniques, it is necessary to locate more accurately the target area and the anatomy of the OARs at each treatment.…”

Section: Introductionmentioning

confidence: 99%

Advantages and Robustness of Partial VMAT with Prone Position for Neoadjuvant Rectal Cancer Evaluated by CBCT-based Offline Adaptive Radiotherapy

Zhang

Peng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background and purpose: This study aims to explore the advantages and robustness of the partial arc combined with prone position planning technique for radiotherapy in rectal cancer patients. Adaptive radiotherapy is recalculated and accumulated on the synthesis CT (sCT) obtained by deformable image registration (DIR) between planning CT and cone beam CT (CBCT). Full and partial volume modulation arc therapy (VMAT) with the prone position on gastrointestinal and urogenital toxicity, based on the probability of normal tissue complications (NTCP) model in rectal cancer patients were evaluated. Materials and methods: Thirty-one patients were studied retrospectively. The contours of different structures were outlined in 155 CBCT images. First, full VMAT (F-VMAT) and partial VMAT (P-VMAT) planning techniques were processed and calculated using the same optimization constraints. The Acuros XB (AXB) algorithm was used in order to generate more realistic dose distributions and DVH, considering the air cavities. Second, the Velocity 4.0 software was used to fuse the planning CT and CBCT to obtain the sCT. Then, the AXB algorithm was used in the Eclipse 13.6 software to conduct re-calculation based on the sCT to obtain the corresponding dose. Furthermore, the LKB NTCP model was used to analyze its radiobiological side effects on the bladder and the bowel bag. Results: With a CTV coverage of 98%, when compared with F-VMAT, P-VMAT with the prone position technique can effectively reduce the mean dose of the bladder and the bowel bag. The LKB NTCP model showed that the P-VMAT combined with the prone planning technique resulted in a significantly lower complication probability of the bladder (1.88±2.08vs1.62±1.41, P=0.041) and the bowel bag (1.77 ± 2.90vs1.57 ± 2.36, P<0.001) than the F-VMAT. In terms of robustness, the P-VMAT is more robust than the F-VMAT, considering the fact that fewer changes were observed in the dose of the CTV, the bladder and the bowel bag. Conclusion: This study analyzed the advantages and robustness of the P-VMAT in the prone position from three aspects, based on the sCT fused by CBCT. Whether it is in regards to dosimetry, radiobiological effects or robustness, P-VMAT in the prone position has shown great advantages.

show abstract

Section: Prostatic Malignanciesmentioning

confidence: 99%

“…This is exemplified by Figure 2, which shows multiple iterations of bowel and rectal contours across treatments that are overlayed to depict the variation that can be observed. The changes in dose due to alteration of internal anatomy on CTgRT have been elaborated and quantified, however such approaches are impractical, adding a significant amount of manpower [33,34]. This theoretical benefit was observed clinically in a prospective, single-arm phase II trial of 101 patients with mostly intermediate-or high-risk localized prostate cancer treated on an MR-Linac with SBRT [4].…”

Section: Prostatic Malignanciesmentioning

confidence: 99%

Towards Accurate and Precise Image-Guided Radiotherapy: Clinical Applications of the MR-Linac

Randall

Ram-Mohan

Das

et al. 2022

JCM

View full text Add to dashboard Cite

Advances in image-guided radiotherapy have brought about improved oncologic outcomes and reduced toxicity. The next generation of image guidance in the form of magnetic resonance imaging (MRI) will improve visualization of tumors and make radiation treatment adaptation possible. In this review, we discuss the role that MRI plays in radiotherapy, with a focus on the integration of MRI with the linear accelerator. The MR linear accelerator (MR-Linac) will provide real-time imaging, help assess motion management, and provide online adaptive therapy. Potential advantages and the current state of these MR-Linacs are highlighted, with a discussion of six different clinical scenarios, leading into a discussion on the future role of these machines in clinical workflows.

show abstract

Relation between DIR recalculated dose based CBCT and GI and GU toxicity in postoperative prostate cancer patients treated with VMAT

Cited by 8 publications

References 20 publications

A Comparison Study Between CNN-Based Deformed Planning CT and CycleGAN-Based Synthetic CT Methods for Improving iCBCT Image Quality

A Comparison Study Between CNN-Based Deformed Planning CT and CycleGAN-Based Synthetic CT Methods for Improving iCBCT Image Quality

Advantages and Robustness of Partial VMAT with Prone Position for Neoadjuvant Rectal Cancer Evaluated by CBCT-based Offline Adaptive Radiotherapy

Towards Accurate and Precise Image-Guided Radiotherapy: Clinical Applications of the MR-Linac

Contact Info

Product

Resources

About