Relation between dietary acrylamide exposure and biomarkers of internal dose in Canadian teenagers

Brisson, Benjamin; Ayotte, Pierre; Normandin, Louise; Gaudreau, Éric; Bienvenu, Jean-François; Fennell, Timothy R.; Blanchet, Carole; Phaneuf, Denise; Lapointe, Caroline; Bonvalot, Yvette; Gagné, Michelle; Courteau, Marilène; Snyder, Rodney W.; Bouchard, Michèle

doi:10.1038/jes.2013.34

Cited by 27 publications

(19 citation statements)

References 32 publications

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“…6,25,28 The results obtained by us seem to confirm that cigarette smoking is an important source of exposure to acrylamide. Similarly as found by Heudorf et al 29 in a group of 110 children in Germany and Brisson et al 31 in group of 195 Canadian teenagers, in our study we did not find any significant differences in the median of urinary levels of AAMA and GAMA in non-smoking women and women passively smoking in the course of pregnancy. Opposite results were obtained by Ji et al 30 in a group of 39 children in Korea.…”

Section: Discussionsupporting

confidence: 90%

“…Acrylamide and glycidamide metabolites in the form of mercapturic acids are excreted in the urine. 27 Several papers published so far 24,25,[28][29][30][31] presented the results of studies on urinary levels of mercapturic derivatives of acrylamide and glycidamide in humans. The possibility of the use of mercapturic derivatives levels for the assessment of exposure to acrylamide from food and tobacco smoke was also presented.…”

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confidence: 99%

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Estimation of exposure to dietary acrylamide based on mercapturic acids level in urine of Polish women post partum and an assessment of health risk

Mojska

Gielecińska

Zielińska

et al. 2015

J Expo Sci Environ Epidemiol

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We determined metabolites of acrylamide and glycidamide concentrations (AAMA and GAMA, respectively) in urine of 93 women within the first days after delivery, using LC-MS/MS. The median AAMA and GAMA levels in urine were 20.9 μg/l (2.3÷399.0 μg/l) and 8.6 μg/l (1.3÷85.0 μg/l), respectively. In smokers we found significantly (P<0.01) higher levels of metabolites in comparison with the non-smoking women. As demonstrated by the 24-h dietary recall, acrylamide intake was low (median: 7.04 μg/day). Estimated exposure to acrylamide based on AAMA and GAMA levels in the whole group of women was 0.16 μg/kg b.w./day (1.15 μg/kg b.w./day, P95). We found significantly (P<0.05) higher exposure in women who consumed higher amount of acrylamide in the diet (≥10 μg/day vs <10 μg/day). A weak but significant positive correlation between acrylamide intake calculated on the basis of urinary levels of AAMA and GAMA and estimated on the basis of 24-h dietary recall (r=0.26, P<0.05) was found. The estimated margin of exposure values were below 10 000 and ranged from 156 for 95th percentile to 1938 for median acrylamide intake. Our results have shown that even a low dietary acrylamide intake may be associated with health risk.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Estimation of exposure to dietary acrylamide based on mercapturic acids level in urine of Polish women post partum and an assessment of health risk

Mojska

Gielecińska

Zielińska

et al. 2015

J Expo Sci Environ Epidemiol

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“…per day (Ji et al, 2013). Brisson et al (2014) studied the relationship between dietary intake of AA and biomarkers of exposure to AA in a group of non-smoking teenagers (n = 195). AA and its metabolites, GA, S-(2-carbamoylethyl)-L-cysteine, AAMA, AAMA-SO, GAMA and iso-GAMA were quantified in urine samples by HPLC-MS/MS.…”

Section: Human Studiesmentioning

confidence: 99%

“…The respective adduct levels were for AA-Hb 30.5 and 13.8 pmol/g Hb, p for trend < 0.001), and for GA-Hb 20.7 and 10.1 pmol/g Hb (p for trend < 0.001). Brisson et al (2014) studied the relationship between dietary intake of AA and biomarkers of exposure in a group of non-smoking teenagers (n = 195). The geometric mean concentration for the AA adduct with N-terminal valine in Hb was 45.4 pmol/g globin and for the GA adduct 45.6 pmol/g globin.…”

Section: Human Studiesmentioning

confidence: 99%

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

337

170

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EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has widespread uses as an industrial chemical. It is also formed when certain foods are prepared at temperatures above 120 °C and low moisture, especially in foods containing asparagine and reducing sugars. The CONTAM Panel evaluated 43 419 analytical results from food commodities. AA was found at the highest levels in solid coffee substitutes and coffee, and in potato fried products. Mean and 95th percentile dietary AA exposures across surveys and age groups were estimated at 0.4 to 1.9 µg/kg body weight (b.w.) per day and 0.6 to 3.4 µg/kg b.w. per day, respectively. The main contributor to total dietary exposure was generally the category 'Potato fried products (except potato crisps and snacks)'. Preferences in home-cooking can have a substantial impact on human dietary AA exposure. Upon oral intake, AA is absorbed from the gastrointestinal tract and distributed to all organs. AA is extensively metabolised, mostly by conjugation with glutathione but also by epoxidation to glycidamide (GA). Formation of GA is considered to represent the route underlying the genotoxicity and carcinogenicity of AA. Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity were identified as possible critical endpoints for AA toxicity from experimental animal studies. The data from human studies were inadequate for dose-response assessment. The CONTAM Panel selected BMDL 10 values of 0.43 mg/kg b.w. per day for peripheral neuropathy in rats and of 0.17 mg/kg b.w. per day for neoplastic effects in mice. The Panel concluded that the current levels of dietary exposure to AA are not of concern with respect to non-neoplastic effects. However, although the epidemiological associations have not demonstrated AA to be a human carcinogen, the margins of exposure (MOEs) indicate a concern for neoplastic effects based on animal evidence. © European Food SUMMARYFollowing a request from the European Commission, the Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on acrylamide (AA) in food. The Panel developed the draft scientific opinion which underwent a public consultation from 1 July 2014 to 15 September 2014. The comments received and how they were taken into account when finalising the scientific opinion were published in an EFSA Technical Report (EFSA, 2015).AA is a low molecular weight, highly water soluble, organic compound. It is used inter alia as an industrial chemical and in the production of polyacrylamides. Heightened concerns about exposure to AA arose in 2002 when it was discovered that it forms when certain foods are prepared at temperatures usually above 120 °C and low moisture. It forms, at least in part, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. However, several other pathways and precursors have also been proposed to contribute to AA formation. AA forms in numerous baked or fried carbohydrate-rich f...

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“…In a study on 195 nonsmoking adolescents in Canada, Brisson et al investigated the urinary metabolites AAMA, AAMA-SO, and GAMA [44]. The most prevalent urinary metabolites were AAMA and AAMA-SO, with respective geometric mean concentrations of 81.7 and 39.7 μg/L.…”

Section: Mercapturic Acid Metabolitesmentioning

confidence: 99%