Relation between Cataract and Metabolic Syndrome and Its Components

Paunksnis, Alvydas; Bojarskiene, Florentina; Cimbalas, Andrius; Černiauskienė, Liucija Rita; Lukšienė, Dalia; Tamošiūnas, Abdonas

doi:10.1177/112067210701700420

Cited by 35 publications

(34 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Two European studies documented a positive association between high BP and cataract. 22,23 In the Blue Mountain Eye Study, antihypertensive medication use was associated with cataract and cataract surgery. 39 The mechanism linking hypertension and cataract is not clear.…”

Section: Discussionmentioning

confidence: 98%

“…A few studies have reported associations of hightriglyceride or low-HDL levels with cataract among specific subpopulations. 12,22,42 Paunskinis et al 22 reported a positive association between high triglyceride levels and any cataract subtype among women aged 45 to 64 years. In the Beaver Dam Eye Study, low HDL levels were associated with cortical cataract in women.…”

Section: Discussionmentioning

confidence: 98%

“…Our finding of a positive association between metabolic syndrome, or two of its components, diabetes and high BP, with cataract is consistent with previous studies conducted in Western populations. [21][22][23] Diabetes and hyperglycemia are established risk factors for cataract, as documented in several populations. 2,3,5,21,22 Diabetes has been shown to be associated with cataract in several Asian populations.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic Syndrome Components and Age-Related Cataract: The Singapore Malay Eye Study

Sabanayagam

Wang

Mitchell

et al. 2011

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Syndrome Components and Age-Related Cataract: The Singapore Malay Eye Study

Sabanayagam

Wang

Mitchell

et al. 2011

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Finally, obesity is potentially linked to ARC secondary to its comorbid cardiometabolic conditions, including diabetes [6], dyslipidemia [7], and hypertension [8], which themselves are known risk factors of ARC [9,10]. The metabolic syndrome, a condition characterized by the following 5 components: central obesity, hyperglycemia, hypertriglyceridemia, hypertension, and reduced serum high-density lipoprotein cholesterol, has been associated with different types of ARC [11,12,13]. Therefore, it has been suggested that the association of ARC is stronger with central obesity than with general obesity [14].…”

Section: Introductionmentioning

confidence: 99%

Obesity and Density of the Crystalline Lens: Revisiting a Growing Dilemma

et al. 2017

View full text Add to dashboard Cite

Background/Aims: Obesity is believed to accelerate age-related cataractogenesis through various biomechanisms. On the contrary, there are also studies advocating the protective role of obesity against the cataract formation process. We investigate the correlation of body mass index (BMI) as a measure for obesity with crystalline optical lens density and opacity in a healthy adult population. Methods: In a cross-sectional setting, 93 consecutive disease-free adult individuals who were working staff of a university-based hospital were assessed for the association between crystalline lens density and opalescence [measured by the objective Pentacam HR lens densitometry and subjective Lens Opacity Classification System III (LOCS III), respectively] with the degree of obesity as defined by BMI. Results: LOCS III and crystalline lens density readings were positively correlated [Spearman rho CC (p value) = 0.224 (0.034)]. However, we found neither LOCS III nor crystalline lens density to be correlated with BMI [Spearman rho CC = −0.008 (p = 0.943) and −0.062 (p = 0.560), respectively]. Conclusions: Results from the present study indicate a lack of association between obesity and densitometry of the crystalline in the adult population group. Further studies are required to confirm the order of causality and pathogenesis of this finding.

show abstract

“…8 Similarly, Paunksnis et al reported increased odds of cataract formation in middle-aged females with arterial hypertension, obesity and hypertriglyceridemia. 9 Diabetes and hyperglycemia are known to promote the glycation of lens proteins and the hyperosmotic effects of sorbitol on lens fibers through the aldose reductase pathway. 10 Leptin has been shown to be involved in cataract formation.…”

Section: Metabolic Syndromementioning

confidence: 99%

Possible mechanisms of development of carcinoma of breast in patients with early-onset cataract

2017

View full text Add to dashboard Cite

Background: A nation-wide population based retrospective cohort study from Taiwan in 2014 suggested a propensity of developing breast cancer in young females with early-onset cataract. One such patient presented to us who was a young non-obese female with a large lump in the right breast with skin nodules and bilateral painless progressive diminution of vision. Patient was diagnosed as locally advanced carcinoma of right breast with axillary metastasis (stage IIIB) and bilateral early-onset nuclear cataract. Mechanism of this possible association has never been described.Methods: A comprehensive online English literature search was done using various electronic search databases. Different search terms related to pathogenesis of carcinoma breast and cataract, and their possible association, were used. An advanced search was further conducted by combining all the search fields in abstracts, keywords, and titles.Results: We summarized the data from the searched articles and found that there are certain biochemical pathways and genetic associations that link cancer to cataract. We identified four specific links between carcinoma breast and cataract (in some cases even early-onset cataract). The four mechanisms which explained this possible association included metabolic syndrome, action of reactive oxygen species, genetic polymorphisms and environmental factors.Conclusions: The evidence linking early-onset cataract with cancer is relatively new so possible mechanisms of development of breast cancer in patients with early-onset cataract needs to be elucidated. These plausible connections can further help to take up large scale molecular, biochemical, epidemiological and clinical studies to investigate this association in terms of cause-effect relationship. The impact this association can have, on understanding cataract and cancer pathogenesis; and its potential in reducing cancer incidence in patients with EOC, can be profound.

show abstract

Relation between Cataract and Metabolic Syndrome and Its Components

Abstract: The results of this study show that the prevalence of cataract in urban women 45-64 years of age with metabolic syndrome was significantly higher than in women of this age without metabolic syndrome.

Cited by 35 publications

References 20 publications

Metabolic Syndrome Components and Age-Related Cataract: The Singapore Malay Eye Study

Metabolic Syndrome Components and Age-Related Cataract: The Singapore Malay Eye Study

Obesity and Density of the Crystalline Lens: Revisiting a Growing Dilemma

Possible mechanisms of development of carcinoma of breast in patients with early-onset cataract

Contact Info

Product

Resources

About