Relation between carbon ion ranges and x‐ray CT numbers

Jäkel, Oliver; Jacob, Christophe; Schardt, D.; Karger, Christian P.; Hartmann, Günther H.

doi:10.1118/1.1357455

Cited by 104 publications

(108 citation statements)

References 4 publications

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“…As this study shows very good results for intracranial cases there is no doubt that a lookup table of CT numbers with the developed scatter correction can still improve these results. In the case of carbon ion therapy, a difference of about 10 HU will result in a range uncertainty of about 1 mm [59]. Whereas for dose calculation for photons an uncertainty of 8% in electron density can lead to a dose uncertainty of only 1% for a 6 MV photon beam and the uncertainty in dose decreases with increasing energy [60].…”

Section: Article In Pressmentioning

confidence: 96%

Enhancement of image quality with a fast iterative scatter and beam hardening correction method for kV CBCT

Reitz

Hesse

Nill

et al. 2009

Zeitschrift für Medizinische Physik

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Section: Article In Pressmentioning

confidence: 96%

Enhancement of image quality with a fast iterative scatter and beam hardening correction method for kV CBCT

Reitz

Hesse

Nill

et al. 2009

Zeitschrift für Medizinische Physik

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“…Table 3 shows the results of the CT scan, where the standard deviations comparable to that of water imply that they were actually homogeneous. We measured the relative stopping powers of the materials with the clinical carbon-ion beams at facility HIMAC (Kanai et al 1999) in a setup similar to those described by Schaffner and Pedroni (1998) and Jäkel et al (2001). The observed range shifts in table 3 by the materials in the box of 96-mm spacing resulted in relative stopping powers 0.818 for ethanol, 0.939 for olive oil, and 1.026 for milk.…”

Section: Carbon Range Verifications With Liquid Biological Materialsmentioning

confidence: 99%

A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning

Kanematsu¹,

Matsufuji²,

Kohno³

et al. 2003

Phys. Med. Biol.

110

112

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Abstract. A method to establish the relationship between CT number and effective density for therapeutic radiations is proposed. We approximated body tissues to mixtures of muscle, air, fat, and bone. Consequently, the relationship can be calibrated only with a CT scan of their substitutes, for which we chose water, air, ethanol, and potassium phosphate solution, respectively. With simple and specific corrections for non-equivalencies of the substitutes, the calibration accuracy of 1% will be achieved. We tested the calibration method with some biological materials to verify that the proposed method would offer accuracy, simplicity, and specificity required for a standard in radiotherapy treatment planning, in particular, with heavy charged particles.

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“…The minimal beam-width is determined by the grid-spacing (uniform in x and y ) according to σ > 1.27 ( x i + 1 - x i ). To calculate the longitudinal extent ( z min - z max ) of the target, CT numbers are converted into particle ranges based on a Hounsfield look-up table [42]. Optimization of N ij is performed by least square minimization such that D ( x , y , z ) meets the prescribed dose.…”

Section: Introductionmentioning

confidence: 99%

4D treatment planning for scanned ion beams

Bert¹,

Rietzel²

2007

Radiat Oncol

110

118

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At Gesellschaft für Schwerionenforschung (GSI) more than 330 patients have been treated with scanned carbon ion beams in a pilot project. To date, only stationary tumors have been treated. In the presence of motion, scanned ion beam therapy is not yet possible because of interplay effects between scanned beam and target motion which can cause severe mis-dosage. We have started a project to treat tumors that are subject to respiratory motion. A prototype beam application system for target tracking with the scanned pencil beam has been developed and commissioned.To facilitate treatment planning for tumors that are subject to organ motion, we have extended our standard treatment planning system TRiP to full 4D functionality. The 4D version of TRiP allows to calculate dose distributions in the presence of motion. Furthermore, for motion mitigation techniques tracking, gating, rescanning, and internal margins optimization of treatment parameters has been implemented. 4D calculations are based on 4D computed tomography data, deformable registration maps, organ motion traces, and beam scanning parameters.We describe the methods of our 4D treatment planning approach and demonstrate functionality of the system for phantom as well as patient data.

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Relation between carbon ion ranges and x‐ray CT numbers

Abstract: Measurements of carbon ion ranges in various phantom materials and real bones are presented. Together with measured Hounsfield values, an empirical relation between ranges and Hounsfield units is derived, which is an important prerequisite for treatment planning in carbon ion therapy.

Cited by 104 publications

References 4 publications

Enhancement of image quality with a fast iterative scatter and beam hardening correction method for kV CBCT

Enhancement of image quality with a fast iterative scatter and beam hardening correction method for kV CBCT

A CT calibration method based on the polybinary tissue model for radiotherapy treatment planning

4D treatment planning for scanned ion beams

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