Relation Between C-Reactive Protein, Homocysteine Levels, Fibrinogen, and Lipoprotein Levels and Leukocyte and Platelet Counts, and 10-Year Risk for Cardiovascular Disease Among Healthy Adults in the USA

Park, Chan Seok; Ihm, Sang‐Hyun; Yoo, Ki‐Dong; Kim, Dong‐Bin; Lee, Jongmin; Kim, Hee-Yeol; Chung, Wook-Sung; Seung, Ki Bae; Kim, Jae-Hyung

doi:10.1016/j.amjcard.2009.12.045

Cited by 62 publications

(36 citation statements)

References 22 publications

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“…Elevated plasma fibrinogen levels have been associated with coronary events both in apparently healthy individuals [1][2][3] and in patients with manifest coronary artery disease (CAD) [4][5][6][7]. Underlying mechanisms that may account for this association have not been fully elucidated as yet, but fibrinogen is known to play an important role in thrombosis [8] and might as well influence the progression of atherosclerotic plaque formation [9,10].…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Buljubasic

Akkerhuis

Cheng

et al. 2017

Coronary Artery Disease

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OBJECTIVE: The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histology-intravascular ultrasound. PATIENTS AND METHODS: In 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, Creactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed. The degree [plaque volume, plaque burden (PB), and lesions with PB70%] and the composition of coronary atherosclerotic plaque (fibrous, fibrofatty, dense calcium, necrotic core tissue, and thin-cap fibroatheroma lesions) were assessed. RESULTS: Fibrinogen showed a tendency toward a positive association with PB [ (95% CI): 2.55 (-0.52-5.61) increase in PB per ln(g/l) fibrinogen, P=0.09], which was driven significantly by an association in the ACS subgroup [ (95% CI): 4.11 (0.01-8.21) increase in PB per ln(g/l) fibrinogen, P=0.049]. Fibrinogen was also related to the presence of lesions with PB 70% or more in both the full cohort [OR (95% CI): 2.27 (1.17-4.43), P=0.016] and ACS patients [OR (95% CI): 2.92 (1.17-7.29), P=0.022]. All associations were independent of established cardiovascular risk factors, but not CRP. Interleukin-6 and plasminogen activator inhibitor-1 did not provide incremental value to fibrinogen when examining the associations with degree of atherosclerosis. Substantial associations with plaque composition were absent. CONCLUSION: Fibrinogen is associated with degree of coronary atherosclerosis, especially in ACS patients. However, whether this association is independent of CRP might be questioned and needs further investigation. Objective The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histologyintravascular ultrasound. Patients and methodsIn 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, C-reactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed. The degree [plaque volume, plaque burden (PB), and lesions with PB ≥ 70%] and the composition of coronary atherosclerotic plaque (fibrous, fibrofatty, dense calcium, necrotic core tissue, and thin-cap fibroatheroma lesions) were assessed.Results Fibrinogen showed a tendency toward a positive association with PB [β (95% CI): 2.55 (− 0.52-5.61) increase in PB per ln(g/l) fibrinogen, P = 0.09], which was driven significantly by an associat...

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Section: Introductionmentioning

confidence: 99%

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Buljubasic

Akkerhuis

Cheng

et al. 2017

Coronary Artery Disease

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“…[10][11][12] Several inflammatory biomarkers, such as high-sensitivity C-reactive protein, interleukin-6, and lipoprotein-associated phospholipase A2, have been associated with coronary artery disease (CAD). [13][14][15] The white blood cell (WBC) count has emerged as one of the easiest to obtain, cheapest, and moreover, best predictive indicators of CV risk. 16 In fact, leukocytes play a crucial role in the progression of atherosclerosis and in destabilization and rupture of a plaque, leading to thrombotic events.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and the Extent of Coronary Artery Disease

et al. 2015

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The neutrophil to lymphocyte ratio (NLR), an inflammatory biomarker, may be of predictive and prognostic value for cardiovascular (CV) events. We evaluated the relationship of NLR with the prevalence and extent of coronary artery disease (CAD) in consecutive patients undergoing elective or urgent coronary angiography. Our population (n ¼ 3738 patients) was divided into NLR quartiles. Higher NLR was associated with aging and established CV risk factors, previous percutaneous coronary revascularization, acute presentation, and more complex pharmacological therapy. The NLR was related to platelet count, white blood cell count, creatinine, glycemia, uric acid, and C-reactive protein (all P ¼ .001) levels but inversely related to hemoglobin (P < .001), total cholesterol (P ¼ .005), and triglycerides (P < .001) levels. The NLR was associated with multivessel disease (P < .001), anterior descending, right coronary arteries (P < .001) or circumflex branch lesions (P ¼ .01), percentage of stenosis (P < .001), coronary calcification (P < .001), and intracoronary thrombus (P < .001) but inversely with in-stent restenosis (P < .001) and thrombolysis in myocardial infarction flow (P ¼ .04). The NLR was directly related to the prevalence of CAD (P ¼ .001) and severe CAD (P < .001). In patients undergoing coronary angiography, the NLR is independently associated with the prevalence and severity of CAD.

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“…However, B vitamin supplementation in adults is not effective in the secondary prevention of CVDs [32,33]. Taking these results into account along with our own leads us to speculate that Hcy concentrations are part of an inflammatory profile, which includes increases in the levels of CRP and fibrinogen [34] associated with the development of CVDs.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association of Homocysteine Concentrations with Oxidative Stress, Alterations in Carotid Intima Media Thickness and Endothelial Reactivity in Prepubertal Children

Souza¹,

D’Almeida

Fonseca

et al. 2013

Ann Nutr Metab

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Background and Aims: Our purpose was to assess the presence of risk factors for cardiovascular diseases (alterations in the lipid profile, fasting glycaemia, high arterial pressure values, oxidative stress, increased intima media thickness and impaired endothelium-dependent vasodilation) in prepubertal children with elevated homocysteine (Hcy) levels. Methods: In a cross-sectional study, 35 children with Hcy levels ≥7.3 μmol/l were matched by gender and age with 29 children with Hcy levels ≤4.1 μmol/l. Our collected data included weight, height, waist circumference, systemic arterial pressure, lipid profile, fasting glycaemia and oxidative stress markers. A Doppler ultrasound was performed to measure the carotid intima media thickness and the endothelium-dependent vasodilation of the brachial artery. Results: There were no statistically significant differences between the groups regarding the lipid profile and fasting glycaemia, blood pressure or oxidative stress. Overweight and obesity (body mass index z-score > +1) were more frequent in the group with Hcy ≥7.3 μmol/l when compared to the group with Hcy ≤4.1 μmol/l [13/35 (37.1%) vs. 4/29 (13.8%); p = 0.035]. After adjusting for nutritional status, there were no differences in the intima media thickness and endothelium-dependent vasodilation between children with high and low Hcy levels. Conclusions: Among the cardiovascular risk factors investigated in the present study, which was based on prepubertal children, only overweight and obesity were associated with increased Hcy concentrations (≥7.3 μmol/l).

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Relation Between C-Reactive Protein, Homocysteine Levels, Fibrinogen, and Lipoprotein Levels and Leukocyte and Platelet Counts, and 10-Year Risk for Cardiovascular Disease Among Healthy Adults in the USA

Cited by 62 publications

References 22 publications

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Fibrinogen in relation to degree and composition of coronary plaque on intravascular ultrasound in patients undergoing coronary angiography

Neutrophil to Lymphocyte Ratio and the Extent of Coronary Artery Disease

Lack of Association of Homocysteine Concentrations with Oxidative Stress, Alterations in Carotid Intima Media Thickness and Endothelial Reactivity in Prepubertal Children

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