Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review.

Tell, Grethe S.; Crouse, John R.; Furberg, C.D.

doi:10.1161/01.str.19.4.423

Cited by 110 publications

(58 citation statements)

References 57 publications

(39 reference statements)

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“…In fact, lipid associations with atherosclerosis of major intracranial arteries are similar to those with coronary arteries 36 and are clearly established with extracranial carotid arteries. 37 Our study shows that carotid thickening is associated with slightly greater proportional elevations in LDL-C than apoB. This differs from the pattern reported for CHD.…”

Section: Discussioncontrasting

confidence: 99%

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

Sharrett

Patsch

Sorlie

et al. 1994

Arterioscler Thromb

175

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Previous research shows generally greater proportional elevation in apolipoprotein B (apoB) levels than in low-density lipoprotein cholesterol (LDL-C) in coronary heart disease (CHD) case subjects compared with control subjects. The Atherosclerosis Risk in Communities study provided general populations of 7261 men and women free of cardiovascular symptoms for evaluating the associations between intima-media thickening in extracranial carotid arteries measured using ultrasound imaging and fasting plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), apoB, apolipoprotein A-I (apoA-I), triglycerides, and HDL density subfractions. A CHD group was selected for comparison. Lipid factors show approximately linear associations with carotid thickness: positive for LDL-C and plasma apoB and negative for HDL-C and apoA-I levels. Apolipoproteins and HDL density subfractions did not contribute to the A ssociations of atherosclerotic diseases with elevated / \ plasma low-density lipoprotein cholesterol -Z \ -(LDL-C) and reduced high-density lipoprotein cholesterol (HDL-C) levels are well established. 1 With increasing knowledge of apolipoprotein functions, 2 the question has arisen as to whether specific apolipoproteins are more strongly associated with atherosclerosis than the cholesterol content of LDL or HDL. Indeed, many studies show greater proportional elevations of mean apolipoprotein B (apoB) than LDL-C in patients with clinical coronary heart disease (CHD), suggesting a difference in LDL composition in many of these patients. 38 Little is known about the interrelations of lipids and apolipoproteins with early subclinical atherosclerosis.

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Section: Discussioncontrasting

confidence: 99%

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

Sharrett

Patsch

Sorlie

et al. 1994

Arterioscler Thromb

175

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show abstract

“…11 There is a strong inverse association between HDL cholesterol and risk of coronary heart disease. 16,17 An inverse relationship between HDL cholesterol and cerebrovascular disease has also been demonstrated, as well as between HDL cholesterol and carotid atherosclerosis, 18 although the results are not as consistent as those for coronary heart disease. The exact mechanism of the protective effect of HDL has been a subject of debate.…”

Section: Discussionmentioning

confidence: 99%

Low Levels of High-Density Lipoprotein Cholesterol Are Associated With Echolucent Carotid Artery Plaques

Mathiesen

Bønaa

Joakimsen

2001

Stroke

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Background and Purpose-Ultrasound-assessed plaque morphology is an independent predictor of ischemic stroke. The purpose of this population-based cross-sectional nested case-control study was to examine the risk factors associated with carotid plaque morphology. Methods-Ultrasonography of the right carotid artery was conducted on 6727 participants in a population health survey (response rate 79%). Plaque echogenicity, defined as reflectance of the emitted ultrasound signal, was scored as echolucent, predominantly echolucent, predominantly echogenic, or echogenic. Information on cardiovascular risk factors in all 216 participants who had carotid stenosis and in 223 control subjects matched by age and sex who did not have carotid stenosis was obtained from measurements of blood pressure, weight, height, and nonfasting blood samples and from a self-administered questionnaire. Results-In both univariate and multivariate analyses, low levels of HDL cholesterol and increasing degree of stenosis were independently associated with an increased risk of having an echolucent plaque. For 1-SD increase in HDL cholesterol, the adjusted odds of being in a lower plaque echogenicity category decreased by Ϸ30% (OR 0.69, 95% CI 0.52 to 0.93). Conclusions-These

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“…28 Other studies have shown no correlation. 29,30 Animal studies have shown that plasmatic arterionecrosis, the causative lesion of hypertensive cerebral hemorrhage, follows upon medial muscle cell necrosis. The earliest cerebral arterial change seen in hypertensive rats was inhibited when these animals were fed a cholesterol and lard-supplemented diet.…”

Section: Study Limitationsmentioning

confidence: 99%

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

et al. 1999

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Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review.

Cited by 110 publications

References 57 publications

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

Low Levels of High-Density Lipoprotein Cholesterol Are Associated With Echolucent Carotid Artery Plaques

Low Serum Cholesterol as a Risk Factor for Hemorrhagic Stroke in Men

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