Relation between blood levels of heavy metals and some markers of oxidative stress among boys with neuropathic bladder and posterior urethral valve

Nabieh, Kareem A.; Helmy, Tamer E.; El-Reash, Y.G. Abou; Mortada, Wael I.

doi:10.1016/j.jtemb.2022.127123

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…Numerous epidemiological studies have indicated that exposure to heavy metals, such as iron (Fe), mercury (Hg), manganese (Mn), copper (Cu), and lead (Pb), induces ROS production, reduces antioxidant levels in cells, and ultimately disrupts redox homeostasis. These processes can lead to OS, DNA damage, mitochondrial dysfunction, and apoptosis, potentially triggering a wide range of diseases, including neurodegenerative and CVDs [30,31].…”

Section: Drugs and Toxic Stimulimentioning

confidence: 99%

Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Yang,

Luo,

Tian

et al. 2024

Antioxidants

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Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous and exogenous factors, the body may produce excessive ROS, which leads to oxidative stress (OS). Numerous studies have shown that OS causes a variety of pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, and protein oxidative modification, all of which can trigger apoptosis and senescence. OS also induces a variety of aging-related diseases, such as retinal disease, neurodegenerative disease, osteoarthritis, cardiovascular diseases, cancer, ovarian disease, and prostate disease. In this review, we aim to introduce the multiple internal and external triggers that mediate ROS levels in rodents and humans as well as the relationship between OS, aging, and aging-related diseases. Finally, we present a statistical analysis of effective antioxidant measures currently being developed and applied in the field of aging research.

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Section: Drugs and Toxic Stimulimentioning

confidence: 99%