Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week

Baena, José Miguel; López, C.O. García; Hidalgo, Antonio Vásquez; Rams, Francesc Rams; Jiménez, Sebastián; Garcia, Manuel; Hernández, Marı́a Rosa

doi:10.1097/00042737-200203000-00014

Cited by 35 publications

(30 citation statements)

References 28 publications

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“…As reported by Roche et al, pKa1 and pKa2 values of esomeprazole are 4.06 and 0.79, respectively, and the values of pantoprazole are 3.83 and 0.11 [20, 21]. In addition, reports showed younger age and alcohol consumption had positive effects on H. pylori eradication [22, 23]. We also observed a similar correlation in our study.…”

Section: Discussionsupporting

confidence: 90%

Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness forHelicobacter pyloriEradication in Taiwanese Population

Shih

Wang

Kuo

et al. 2012

Gastroenterology Research and Practice

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Background and Study Aims. To compare the effectiveness of two regimens, single-dose esomeprazole- and pantoprazole-based triple therapy, for Helicobacter pylori (H. pylori) eradication. Patients and Methods. A total of 453 patients were enrolled for H. pylori eradication. They were randomly assigned to either EAC group (Esomeprazole 40 mg once daily, Amoxicillin 1 g twice daily, Clarithromycin 500 mg twice daily for 7 days) or PAC group (Pantoprazole 40 mg twice daily, Amoxicillin 1 g twice daily, Clarithromycin 500 mg twice daily for 7 days). Follow-up endoscopy or urea breath test was scheduled 12–16 weeks after the eradication to evaluate the therapeutic response. Results. Higher eradication rate in EAC group than PAC group was shown by intention-to-treat analysis (EAC 72% versus PAC 55%, P < 0.05) and per-protocol analysis (EAC 91% versus PAC 72%, P < 0.05). The incidence of adverse effects (EAC 19% versus PAC 17%, P = 0.712) and the compliance (EAC 87% versus PAC 91%, P = 0.083) were comparable between these 2 groups. Conclusions. Single-dose esomeprazole-based triple therapy is effective for H. pylori eradication.

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Section: Discussionsupporting

confidence: 90%

Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness forHelicobacter pyloriEradication in Taiwanese Population

Shih

Wang

Kuo

et al. 2012

Gastroenterology Research and Practice

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“…Baena et al [82] studied another coherence of H. pylori infection and alcohol consumption. The daily alcohol consumption was the only variable signifi cantly associated with the success rate of eradication therapy, with a higher probability of failure in non-consumers (29.9%) than in consumers (12.2%), the adjusted odds ratio was 3.24.…”

Section: Helicobacter Pylori Infectionsmentioning

confidence: 99%

Alcohol-Related Diseases of the Esophagus and Stomach

Franke

Teyssen²,

Singer³

2005

Dig Dis

169

100

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The present review summarizes the clinically relevant effects of acute and chronic alcohol consumption on motility, mucosal inflammation and cancer of the esophagus and the stomach. Alcohol consumption results in a significant increase in the morbidity of these two organs, the most important probably being the significant increase in the development of esophageal cancer. This review refers to epidemiologic and systematic experimental data to elucidate the clinical impact of alcohol consumption as well as the underlying alcohol-induced pathophysiologic mechanisms for these esophageal and gastric diseases. Much research is still needed to clarify the effects of alcohol itself and the byproducts that result during the production of the different types of alcoholic beverages on dismotility and mucosal injury to the esophagus and stomach.

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“…The role of alcoholic beverages in defence against H. pylori infection has been reported widely (Murray et al ; Kuepper‐Nybelen et al ; Gao et al ). Daily moderate alcohol consumption appears to have an additive effect in the triple eradication therapy (Baena et al ). In this work, synergistic effect of resveratrol and alcohol has been identified, which would add an additional explanation for the anti‐ H. pylori effect of red wine.…”

Section: Discussionmentioning

confidence: 99%

The synergy of resveratrol and alcohol against Helicobacter pylori and underlying anti‐ Helicobacter pylori mechanism of resveratrol

2019

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Aims To determine individual antibacterial and synergistic antibacterial effects of resveratrol and alcohol against Helicobacter pylori 26695 in vitro, and to elucidate the underlying mechanism of action of resveratrol against H. pylori. Methods and Results The minimum inhibitory concentrations (MICs) and time‐killing curve of resveratrol and alcohol were determined. Transcriptome analysis by RNA sequencing was used to elucidate the underlying mechanism of action of resveratrol against H. pylori. Our results showed that the MICs of resveratrol and alcohol against H. pylori 26695 are about 64 μg ml−1 and 4% (v/v) respectively. The synergy was found: resveratrol at concentration of 64 μg ml−1 in combination with alcohol at concentration of 4% (v/v) showed >10 000‐fold decrease in the mount of viable bacteria compared with resveratrol and alcohol used alone. Transcriptome analysis showed 152 genes were downregulated and 111 genes were upregulated in the presence of resveratrol. Genes involved in protein translation (17·1%), outer membrane proteins (OMPs) (9·9%) and transports (11·2%) comprise 38·2% of the downregulated genes. In comparison, genes involved in redox (13·5%), pathogenesis and motility (9·9%) and iron homeostasis (4·5%) comprise 27·9% of the upregulated genes. Conclusions The synergy of resveratrol and alcohol against H. pylori was found in this study. The underlying mechanism of action of resveratrol against H. pylori may be mainly attributed to its inhibitory effect on translation, OMPs, transports, ATP synthase and possible oxidative damage. Significance and Impact of this Study Our study provides a global insight into the anti‐H. pylori mechanism of resveratrol. Both resveratrol and alcohol can contribute to inhibition of ribosomes, changes in OMPs and oxidative damage, which may be the explanations of synergistic effect against H. pylori elicited by resveratrol and alcohol.

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Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week

Abstract: Daily alcohol consumption appears to have an additive effect in this eradication therapy.

Cited by 35 publications

References 28 publications

Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness forHelicobacter pyloriEradication in Taiwanese Population

Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness forHelicobacter pyloriEradication in Taiwanese Population

Alcohol-Related Diseases of the Esophagus and Stomach

The synergy of resveratrol and alcohol against Helicobacter pylori and underlying anti‐ Helicobacter pylori mechanism of resveratrol

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