Relation among mannose-binding lectin 2 genotype, β-cell autoantibodies, and risk for type 1 diabetes in Finnish children

Association between MBL2 polymorphism and T1D: Does ethnicity play a role in the susceptibility of this multifactorial disease?

“…Moreover, MBL2 polymorphism allelic and genotype frequencies of the 529 northeastern Brazilian controls were perfectly matched with those reported in our previous study [1] and the frequencies determined for Caucasians were equivalent to the frequencies reported for the Finnish population [2]. Only the African population demonstrated significantly different MBL2 frequencies compared with the Finnish, northeastern Brazilian, and Caucasian populations (see Table 1 for details).…”

“…Recently, Aittoniemi et al analyzed MBL2 functional polymorphisms in a larger group of Finnish T1D patients (470) and controls (501) and reported no correlation between MBL2 polymorphisms and the risk of developing T1D [2]. Thus, we decided to check and revise our results in an attempt to explain the different findings reported in our study and that of Aittoniemi et al…”

“…Furthermore, the incidence of T1D in Finnish and northeastern Brazilian pop-ABBREVIATIONS T1D type 1 diabetes genotype p ϭ 0.074; allele p ϭ 0.016 a Aittoniemi et al [2]. b Araujo et al [1].…”

Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection

“…In support of adequate control population stratification, the prevalence of MBL2 structural variant genotypes in symptomatic HSV-2 patients seemed to be higher than in two other previously published, large control studies of 400 and 501 Finnish subjects [18,19]. Furthermore, in patients with recurrent HSV-2 infection, the structural variant genotype seemed to be associated with more severe primary infection, and the number of recurrences per year and the occurrence of radicular neuralgias seemed to be somewhat higher, although statistical significance was not reached.…”

Association between mannose-binding lectin, high-sensitivity C-reactive protein and the progression of diabetic nephropathy in type 1 diabetes

“…In humans, MBL levels vary significantly from person to person because of frequently occurring polymorphisms within exon 1 as well as in the promoter region of the MBL2 gene on chromosome 10 [7,8]. The MBL2 gene is not a type 1 diabetes susceptibility gene per se [9], but patients with type 1 diabetes have significantly increased serum levels of MBL [10,11], and both high circulating levels of MBL and high-coding MBL genotypes are associated with the presence and development of microalbuminuria and diabetic nephropathy [12][13][14].…”