Relation Among Anxiety, Depression, Sleep Quality and Health-Related Quality of Life Among Patients with Systemic Lupus Erythematosus: Path Analysis

Abstract

Purpose This study aimed to examine the relationship between anxiety, depression, sleep quality and health-related quality of life among systemic lupus erythematosus (SLE) patients in China. Patients and Methods After ethical approval and obtaining participants’ informed consent, a cross-sectional study was conducted in The First Affiliated Hospital of Anhui Medical University between October 1, 2021 and January 30, 2022. The data comprised demographic information, number of SLE symptoms, Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI) and Systemic Lupus Erythematosus-Specific Quality of Life Questionnaire (SLEQoL). We performed descriptive statistics, Spearman or Pearson correlations, and multiple linear regression. And Path analysis was performed to examine direct and indirect associations between these variables and health-related quality of life. Results A total of 580 patients were recruited and 513 met our target criteria. Our final model fitted the data well: goodness-of-fit index (GFI) =0.996; adjusted goodness-of-fit index (AGFI) =0.974; comparative fit index (CFI) =0.998; root mean square error of approximation (RMSEA) =0.043. This model explained 57.3% of the variance on health-related quality of life (HRQoL) in patients with SLE and all the hypothesized paths reached significance ( P <0.05). Anxiety, depression, sleep quality, income/family, and number of SLE symptoms were related to health-related quality of life, and anxiety had the most influence on HRQoL (β=0.561). Conclusion The study model helps to explain the relation among anxiety, depression, sleep quality and health-related quality of life in patients with SLE. It also suggests that health care professionals should be aware of factors such as anxiety, sleep quality, number of SLE symptoms, and depression in their care for HRQoL of SLE patients.

Systemic Lupus Erythematosus Outpatients Medication Knowledge and Quality of Life

“…The shortest has been diagnosed only six months before the research, the longest has been diagnosed for 33 years by J Pharm Sci Clin Res, 2023, 01 110 the clinician. This shown that SLE is a chronic disease, which stated in many studies (Chen et al, 2022). The demographic data of the respondents are shown in table 2.…”

“…In Brazil, the prevalence ranges from 20 to 150 cases per 100,000 persons with the most prevalence were reported, and it appears to be growth more and more. People of Black/African American or Asian origin have a higher risk for SLE than White/Caucasian individuals, and show more serious disease phenotypes (Chen et al, 2022;Carrasco et al, 2013). Some data in Indonesia are obtained from hospitalized patients.…”

“…Analyzing the quality of life (QoL) is thus an important measure to examine how much the chronic disease process is influencing the SLE patients. There is a paucity of literature on QoL issues in SLE patients from Asia (Chen et al, 2022).…”

Positive psychological capital, post-traumatic growth, social support, and quality of life in patients with systemic lupus erythematosus: A cross-sectional study

“…29 The financial burden of treatment and regular followups for SLE patients is a significant expense for families, especially considering the low per capita monthly family income. 30 This increased financial pressure can further diminish the QOL of SLE patients. Employment status 31 is another factor impacting QOL, as working late shifts may similarly affect overall well-being.…”

Development of a nomogram prediction model for depression in patients with systemic lupus erythematosus

“…The total score ranges from 0 to 21, with higher scores indicating poorer sleep quality. The PSQI demonstrated good validity and reliability among the Chinese patient population ( Chen et al, 2022 ).…”