Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease

Abstract

Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. Flies have been successfully applied to many aspects of health-based research spanning from behavioural addiction, to dysplasia, to RNA dysregulation and protein misfolding. Recently, Drosophila tissues have been used to study biomolecular condensates and their role in multicellular systems. Identified in a wide range of plant and animal species, biomolecular condensates are dynamic, non-membrane-bound sub-compartments that have been observed and characterised in the cytoplasm and nuclei of many cell types. Condensate biology has exciting research prospects because of their diverse roles within cells, links to disease, and potential for therapeutics. In this review, we will discuss processing bodies (P bodies), a conserved biomolecular condensate, with a particular interest in how Drosophila can be applied to advance our understanding of condensate biogenesis and their role in disease.

A Balancing Act: The Viral-Host Battle over RBPs

“…Processing bodies are thought to be sites of RNA metabolism within the cytoplasm of cells. Pbodies have been implicated in mRNA decay, translation repression, nonsense mediated decay (NMD), as well as mRNA silencing [76,[92][93][94][95][96][97]. They have commonly been identified as sites of mRNA decay due several constituents' ties to transcript degradation, namely DDX6, DCP1, DCP2, Xrn1, EDC3, EDC4, among others [69][70][71][72][73][74][75][76][77][78][79][80].…”