Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations

Higgins, Stephen T.; DeSarno, Michael; Davis, Danielle R.; Nighbor, Tyler D.; Streck, Joanna M.; Adise, Shana; Harfmann, Roxanne F.; Nesheim-Case, Riley; Markesich, Catherine; Reed, Derek D.; Tyndale, Rachel F.; Gaalema, Diann E.; Heil, Sarah H.; Sigmon, Stacey C.; Tidey, Jennifer W.; Villanti, Andrea C.; Lee, Dustin; Hughes, John R.; Bunn, Janice Y.

doi:10.1016/j.ypmed.2020.106189

Cited by 10 publications

(8 citation statements)

References 41 publications

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“…The present study was conducted with the primary aim of examining the factor-loading pattern of a hypothetical CPT in a sample of pregnant women who smoke. The present study revealed a two-factor solution, interpreted as amplitude and persistence, consistent with prior research conducted in other populations including vulnerable populations (e.g., economically disadvantaged women, Higgins et al, 2020; adults with opioid use disorder, Higgins et al, 2020; adults with affective disorders, González-Roz et al, 2020; Higgins et al, 2020; adults with alcohol use disorder, Cui et al, 2021; and adolescents, Bidwell et al, 2012). O max and intensity loaded onto amplitude where all other indices and O max loaded onto persistence in the present study, which is largely consistent with prior studies where only intensity or intensity and O max loaded onto amplitude and all of the other indices loaded onto persistence.…”

Section: Discussionsupporting

confidence: 89%

“…In the present study, we explore the latent-factor structure of the CPT indices via principal component analysis. A two-factor solution has been reported in prior studies in large (O’Connor et al, 2016; N = 1,194) and smaller (Athamneh et al, 2019; N = 119) samples of adult smokers from the general population (e.g., “daily adult cigarette smokers”) and a large sample of adult smokers[from vulnerable populations ( N = 745; Higgins et al, 2020)]. Wherein intensity loaded exclusively onto amplitude, defined as volumetric consumption or expenditure in total volume, and all other indices loaded exclusively onto persistence, defined as consumption as a function of price.…”

mentioning

confidence: 84%

“…In the spirit of the U.S. National Institute of Mental Health's Research Domain Criteria (RDoC) initiative (National Institute of Mental Health, 2019), which recommends characterizing psychiatric disorders in terms of underpinning psychological and biological processes rather than individual symptoms, we examined individual differences in potential motivational processes underpinning smoking during pregnancy with a particular focus on the reinforcing value of smoking (Higgins et al, 2017(Higgins et al, , 2020Nighbor et al, 2019). We focused on the reinforcement process due to the broad scientific consensus that chronic smoking is largely attributable to the reinforcing effects of nicotine (Prochaska & Benowitz, 2019;U.S.…”

Section: Public Health Significancementioning

confidence: 99%

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Examining the latent factor structure of a hypothetical cigarette purchase task among pregnant women.

Evemy¹,

Kurti²,

Skelly³

et al. 2023

Experimental and Clinical Psychopharmacology

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The cigarette purchase task (CPT) is a valid behavioral-economic measure of demand that has smokers estimate hypothetical cigarette consumption under a range of escalating prices. The task involves no experimenter exposure of participants to smoking. CPT demand is measured in terms of five indices: intensity (cigarettes consumed at $0), Omax (largest expenditure), Pmax (price associated with peak expenditure), breakpoint (the first price at which consumption is 0), and elasticity (rate at which consumption changes as a function of increasing price). Out of concern for collinearity, prior studies investigated a more parsimonious CPT latent-factor structure for these derived indices consisting of two factors. The present study examined whether the same two latent-factor solutions extend to pregnant women who smoke. Six hundred sixty-five women completed the CPT as part of recruitment for a clinical trial examining the efficacy of a remote contingency-management intervention to promote smoking cessation during pregnancy. Factor analysis confirmed a two-factor solution to the CPT accounting for 87% of the variance in the five indices with demand intensity and Omax loading onto amplitude and Omax, Pmax, breakpoint, and elasticity loading onto persistence. Backward elimination regression revealed a significant negative relationship between amplitude and persistence (i.e., lower amplitude and persistence scores predicted a higher likelihood of making at least one quit attempt upon learning of pregnancy). These results further support the utility of the CPT for experimentally examining individual differences in smoking among pregnant women in an efficient and ethical manner that does not involve exposing them to cigarette smoke.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 84%

Section: Public Health Significancementioning

confidence: 99%

See 1 more Smart Citation

Examining the latent factor structure of a hypothetical cigarette purchase task among pregnant women.

Evemy¹,

Kurti²,

Skelly³

et al. 2023

Experimental and Clinical Psychopharmacology

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“…To our knowledge, no studies have examined demand amplitude ( Q 0 ) and cross-commodity delay discounting of substances in clinical populations, but several studies have found that demand amplitude is correlated with addiction severity (e.g., Aston et al, 2017; Higgins et al, 2020) and addiction severity is negatively correlated with the rate of discounting, consistent with the implications of the simulation shown in Figure 12. For example, Naudé et al (2021) found that alcohol use severity had a significantly negative correlation with delay discount rate when the delayed larger commodity was alcohol but a significant positive correlation with discount rate when the delayed larger commodity was money, and no correlation to discount rate for money versus money.…”

Section: Discussionsupporting

confidence: 62%

A general model of demand and discounting.

Hursh

Schwartz

2023

Psychology of Addictive Behaviors

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Objective: A simulation using a two-commodity demand model, with time as the constraint, replicated the primary findings from delay discounting experiments and introduces explicit terms for time elasticity and cross-price substitution into the delay discounting paradigm. Method: A two-commodity temporal demand equation based on Hursh and Silberberg (2008) and Hursh (2014) was used to emulate delay discounting experiments. The own-price and cross-price demand curves intersected and plotting those indifference points emulated the usual hyperbolic discount function for substitutes. Simulations examined delay discounting in relation to (a) time elasticity of demand, (b) substitution between the delayed and immediate alternatives, and (c) amplitude of demand for the delayed alternative. Results: The simulated discount functions with substitutes were hyperbolic. The discount rate was a direct function of increasing time elasticity and substitutability of delayed alternative demand, shifting the function toward an exponential model. Amplitude of demand for the delayed alternative was inversely proportional to discount rate and supported a hyperboloid model with a power function of time (Killeen, 2015; Rachlin, 2006). The emulation of cross-commodity discounting involving drugs points to amplitude and persistence of time-dependent demand and cross-commodity substitution as primary factors. Conclusions: This report describes the first general model of time-dependent demand and delay discounting. The model implicates cross-commodity substitution as a potential factor in delay discounting. In the context of substance use disorder, the model underscores the importance of defining the properties of multicommodity demand (time elasticity, substitution, and amplitude) specific to the commodities and context.

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“… 10 , 11 , 12 Secondary CPD outcomes included changes in total, study, and nonstudy CPD across weeks. Other secondary outcomes included nicotine dependence severity based on Fagerström Test for Nicotine Dependence 28 total scores (minus CPD item) and Wisconsin Inventory of Smoking Dependence Motives (Brief WISDM) total and primary dependence motive and secondary dependence motive subscale scores, 29 breath CO, 30 urinary cotinine and NNAL (marker of tobacco-specific n-nitrosamine exposure) level, 31 , 32 , 33 , 34 , 35 Cigarette Purchase Task, 36 , 37 , 38 , 39 smoking topography, 40 craving or withdrawal using Questionnaire on Smoking Urges Brief (QSU-Brief) 41 and Minnesota Tobacco Withdrawal Scale 42 scores, and during-study and poststudy abstinence outcomes. 10 , 12 , 27 …”

Section: Methodsmentioning

confidence: 99%

Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage

et al. 2020

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Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations

Cited by 10 publications

References 41 publications

Examining the latent factor structure of a hypothetical cigarette purchase task among pregnant women.

Examining the latent factor structure of a hypothetical cigarette purchase task among pregnant women.

A general model of demand and discounting.

Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage

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