Relatedness of chloramphenicol resistance plasmids in epidemiologically unrelated strains of pathogenic Escherichia coli from man and animals

Jørgensen, Sigrid Tue

doi:10.1099/00222615-16-2-165

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…Overall, eight studies (18%) suggested to have data to support transfer of AMR bacteria and/or their AMR determinants from food animals to humans (Levy, 1978 ; Al-Ghamdi et al , 1999 ; van den Bogaard et al , 2001 ; Hammerum et al , 2006 ; Johnson et al , 2006 ; Leverstein-van Hall et al , 2011 ; Giufre et al , 2012 ; Dierikx et al , 2013 ), while 25 studies (56%) presented data showing overlap of AMR bacteria and AMR determinants between food animals and humans, indicating the possibility of between-host AMR transmission but with no direction specified (Jorgensen, 1983 ; Oppegaard et al , 2001 ; Winokur et al , 2001 ; Ho et al , 2009 , 2010 ; Moodley and Guardabassi, 2009 ; Mulvey et al , 2009 ; Smet et al , 2009 ; Zhang et al , 2009 ; Jakobsen et al , 2010 , 2011 ; Zhao et al , 2010 ; Deng et al , 2011 ; Vieira et al , 2011 ; Stokes et al , 2012 ; Ciccozzi et al , 2013 ; Hu et al , 2013 ; de Been et al , 2014 ; Hammerum et al , 2014 ; Valentin et al , 2014 ; Dahms et al , 2015 ; Dohmen et al , 2015 ; Huijbers et al , 2015 ; Lupindu et al , 2015 ; Tseng et al , 2015 ), and 12 studies (26%) did not suggest to find evidence supporting transmission between food animals and humans (Kariuki et al , 1997 , 1999 ; Maynard et al , 2004 ; Kang et al , 2005 ; Phongpaichit et al , 2007 ; Graziani et al , 2009 ; Schwaiger et al , 2010 ; Xia et al , 2010 ; Johnson et al , 2012 ; Riccobono et al , …”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies found that unrelated human and food animal isolates shared identical AMR genes, integrons and plasmids (Oppegaard et al , 2001 ; Winokur et al , 2001 ; Ho et al , 2009 , 2010 ; Moodley and Guardabassi, 2009 ; Mulvey et al , 2009 ; Smet et al , 2009 ; Zhang et al , 2009 ; Stokes et al , 2012 ; Huijbers et al , 2015 ; Tseng et al , 2015 ). One study identified identical plasmids encoding chloramphenicol resistance in unrelated human and food animal isolates (Jorgensen, 1983 ).…”

Section: Resultsmentioning

confidence: 99%

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Are Food Animals Responsible for Transfer of Antimicrobial-ResistantEscherichia colior Their Resistance Determinants to Human Populations? A Systematic Review

Muloi

Ward

Pedersen

et al. 2018

Foodborne Pathogens and Disease

134

100

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The role of farm animals in the emergence and dissemination of both AMR bacteria and their resistance determinants to humans is poorly understood and controversial. Here, we systematically reviewed the current evidence that food animals are responsible for transfer of AMR to humans. We searched PubMed, Web of Science, and EMBASE for literature published between 1940 and 2016. Our results show that eight studies (18%) suggested evidence of transmission of AMR from food animals to humans, 25 studies (56%) suggested transmission between animals and humans with no direction specified and 12 studies (26%) did not support transmission. Quality of evidence was variable among the included studies; one study (2%) used high resolution typing tools, 36 (80%) used intermediate resolution typing tools, six (13%) relied on low resolution typing tools, and two (5%) based conclusions on co-occurrence of resistance. While some studies suggested to provide evidence that transmission of AMR from food animals to humans may occur, robust conclusions on the directionality of transmission cannot be drawn due to limitations in study methodologies. Our findings highlight the need to combine high resolution genomic data analysis with systematically collected epidemiological evidence to reconstruct patterns of AMR transmission between food animals and humans.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Are Food Animals Responsible for Transfer of Antimicrobial-ResistantEscherichia colior Their Resistance Determinants to Human Populations? A Systematic Review

Muloi

Ward

Pedersen

et al. 2018

Foodborne Pathogens and Disease

134

100

View full text Add to dashboard Cite

show abstract

“…Antimicrobial-agent-resistant E. coli of animal origin has been proposed to constitute an important potential source of R plasmids for indigenous E. coli in the human gut and, subsequently, for human pathogens (26,40). In fact, apparently related plasmids have been found in epidemiologically unrelated E. coli isolates from humans and pigs (20,33). The present work demonstrates that R plasmids can spread among bacterial strains of human, animal, and fish origins that are unrelated either evolutionarily or ecologically, even under simulated natural conditions in the absence of antimicrobial agents.…”

Section: Discussionmentioning

confidence: 99%

Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments

Kruse

Sørum

1994

Appl Environ Microbiol

282

114

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Plasmids harboring multiple antimicrobial-resistance determinants (R plasmids) were transferred in simulated natural microenvironments from various bacterial pathogens of human, animal, or fish origin to susceptible strains isolated from a different ecological niche. R plasmids in a strain of the human pathogen Vrbrio cholerae 01 El Tor and a bovine Escherichia coli strain were conjugated to a susceptible strain of the fish pathogenic bacterium Aeromonas salmonicida subsp. salmonicida in marine water. Conjugations of R plasmids between a resistant bovine pathogenic E. coli strain and a susceptible E. coli strain of human origin were performed on a hand towel contaminated with milk from a cow with mastitis. A similar conjugation event between a resistant porcine pathogenic E. coli strain and a susceptible E. coli strain of human origin was studied in minced meat on a cutting board. Conjugation of R plasmids between a resistant strain of the fish pathogenic bacterium A. salmonicida subsp. salmonicida and a susceptible E. coli strain of human origin was performed in raw salmon on a cutting board. R plasmids in a strain of A. salmonicida subsp. salmonicida and a human pathogenic E. coli strain were conjugated to a susceptible porcine E. coli strain in porcine feces. Transfer of the different R plasmids was confirmed by plasmid profile analyses and determination of the resistance pattern of the transconjugants. The different R plasmids were transferred equally well under simulated natural conditions and under controlled laboratory conditions, with median conjugation frequencies ranging from 3 x 10-6 to 8 x 10-3. The present study demonstrates that conjugation and transfer of R plasmids is a phenomenon that belongs to the environment and can occur between bacterial strains of human, animal, and fish origins that are unrelated either evolutionarily or ecologically, even in the absence of antibiotics. Consequently, the contamination of the environment with bacterial pathogens resistant to antimicrobial agents is a real threat not only as a source of disease but also as a source from which R plasmids can easily spread to other pathogens of diverse origins.

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“…In our previous study (20) Studies designed to follow the evolution of R plasmids and to assess their spread, such as that described by J0rgensen (13), are few. The major difficulty in this type of study is the generally high level of plasmid-borne resistance to the antibiotic under study that is already circulating.…”

Section: Downloaded Frommentioning

confidence: 99%

Evolution and spread of IncFIV plasmids conferring resistance to trimethoprim

Campbell¹,

Mee²,

Nikoletti³

1986

Antimicrob Agents Chemother

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Twenty-one IncFIV-group plasmids conferring trimethoprim resistance in Escherichia coli isolates from humans and pigs were examined. Three evolutionary lines of plasmids were identified on the basis of restriction enzyme analysis. One (14) on chloramphenicol-resistant IncFII plasmids, and by Konarska-Kozlowska and Iyer (15) on a group of IncN plasmids. Results of these studies found that many of the restriction enzyme fragments generated were common and that plasmid functions were retained on restriction fragments of the same size. Our results suggest that there has been considerable evolution among the IncFIV plasmids and that a Tpr Escherichia coli has transferred from humans to pigs (or vice versa) and successfully colonized both ecosystems.

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Relatedness of chloramphenicol resistance plasmids in epidemiologically unrelated strains of pathogenic Escherichia coli from man and animals

Cited by 11 publications

References 8 publications

Are Food Animals Responsible for Transfer of Antimicrobial-ResistantEscherichia colior Their Resistance Determinants to Human Populations? A Systematic Review

Are Food Animals Responsible for Transfer of Antimicrobial-ResistantEscherichia colior Their Resistance Determinants to Human Populations? A Systematic Review

Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments

Evolution and spread of IncFIV plasmids conferring resistance to trimethoprim

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