Related Risk Factors between Subclinical Carotid Atherosclerosis and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetes Mellitus in China

Abstract

Purpose To analyze the clinical features and related risk factors in diabetic retinopathy (DR) and subclinical atherosclerosis, the micro- and macro-vascular diseases in newly diagnosed type 2 diabetes mellitus (T2DM). Methods A retrospective study of 435 cases of inpatients with newly diagnosed T2DM from 2013–2017, and compare the 2 types of T2DM related vascular complications. Results The macro- and microvascular complications are not rare at this stage. Subclinical atherosclerosis was found in 251 subjects (57.7%), which was higher than that of DR (13.1%). In addition, some cases of subclinical atherosclerosis co-existed with DR, suggesting that DR was related with subclinical atherosclerosis (r=0.098, P=0.041). Older age showed a significant association with both subclinical atherosclerosis and DR. Single factor analysis indicated that dyslipidemia was the common risk factor in DR and subclinical atherosclerosis. Conclusions It should be paid attention to the screening of both DR and subclinical atherosclerosis in each age group of newly diagnosed T2DM. Except for the control of blood glucose, the control of the dyslipidemia is important in the prevention and treatment of the micro- and macro-vascular diseases.

Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy

“…DR has been related to subclinical atherosclerosis plaque in both T1D [ 14 ] and T2D [ 9 , 19 , 50 ]. Apart from its role as a risk factor for the development of atherosclerosis and CV disease, accumulating evidence suggests that diabetic dyslipidemia may play a role in DR progression [ 51 , 52 ].…”

Diabetic retinopathy risk prediction in patients with type 2 diabetes mellitus using a nomogram model

“…In addition, lipotoxicity, damage to the retinal barrier caused by excessive blood lipids, and exceptionally high TGs are a vital part of DR ( 24 , 25 ). Thus, controlling dyslipidemia in addition to glycemic management is critical for preventing and treating DR ( 26 ). According to the independent variables assessed in our prediction model, HbA1c and lipids could be risk factors for DR.…”

Recent Advances and the Mechanism of Astaxanthin in Ophthalmological Diseases

“…Diabetic retinopathy (DR) is one of the important and common microvascular complications of diabetes mellitus (DM) [67]. It is reported as one of the major causes of blindness and visual impairment in adults [68]. Oxidative stress and inflammation are the two determinant factors in the initiation and progression of DR [69].…”