Related Markers for the Precision Diagnosis of Complex Appendicitis in Children

Zhou, Jialin; Xu, Wenjing; Wang, Jitao; Fan, Zhe

doi:10.3389/fphar.2022.865303

Cited by 4 publications

(3 citation statements)

References 83 publications

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“…However, the identification of patients with non-complicated AA is still challenging. As CT scans involve radiation and are generally avoided for pediatric diagnostics [ 74 ], the prediction of complicated AA typically relies on patient history, clinical findings, laboratory values such as WBC count, granulocyte count, CRP concentration, and ultrasound [ 75 , 76 ]. Many efforts have been made to find new biomarkers to help differentiate between complicated and uncomplicated appendicitis [ 77 ].…”

Section: Acute Appendicitismentioning

confidence: 99%

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

Dölling,

Herrmann,

Boettcher

2024

Children

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This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in pediatric surgery. Focusing on NET formation, functions, and implications, this study highlights their dual impact in infection control and contribution to tissue damage after surgery. It covers the role of NET formation in a range of pediatric conditions including immunothrombosis, formation of peritoneal adhesions, appendicitis, burns, gallstones, tumors, and necrotizing enterocolitis (NEC). The results underscore the significance of NETs in fighting infections and their association with complications like sepsis and delayed wound healing. The breakdown products of NETs as a diagnostic tool of the clinical course of acute appendicitis will also be discussed. Understanding NET formation in the pathophysiology can potentially help to find new therapeutic approaches such as the application of DNase and elastase inhibitors to change the clinical course of various diseases in pediatric surgery such as improvement of wound healing, adhesion formation, NEC, and many more.

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Section: Acute Appendicitismentioning

confidence: 99%

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

Dölling,

Herrmann,

Boettcher

2024

Children

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“…Classically, the rapid diagnosis of acute appendicitis is commonly based on a brief detailed history, a focused physical examination, and directed laboratory findings that consist of clinical diagnostic scoring systems [ 12 ]. The Alvarado score, appendicitis inflammatory response score, and the pediatric appendicitis score have been clinically applied for diagnosing appendicitis and may be helpful for clinical application [ 13 , 14 , 15 ]. Recently, laboratory markers in differentiation between uncomplicated and complicated appendicitis have been explored.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

Lin,

Lee,

Chen

et al. 2024

Diagnostics

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Background: Acute appendicitis is a common abdominal emergency observed in emergency departments (ED). Distinguishing between uncomplicated and complicated appendicitis is important in determining a treatment strategy. Serum soluble vascular cell adhesion molecule-1 (VCAM-1) is an inflammatory biomarker. We aimed to determine the role of VCAM-1 in predicting complicated appendicitis in children. Methods: Pediatric patients with suspected appendicitis admitted to the ED were enrolled in this prospective study. Pre-surgical serum VCAM-1 was tested in children with acute appendicitis within 72 h of symptoms (from day 1 to day 3). Serum VCAM-1 levels were further analyzed and compared between patients with and without complicated appendicitis. Results: Among the 226 pediatric appendicitis patients, 70 had uncomplicated appendicitis, 138 had complicated appendicitis, and 18 had normal appendices. The mean serum VCAM-1 levels in patients with perforated appendicitis were higher than in those with simple appendicitis (p < 0.001). On day 1 to day 3, the mean VCAM-1 levels in patients with complicated appendicitis were all significantly higher than in those with uncomplicated appendicitis (all p < 0.001). Conclusion: Serum VCAM-1 levels may be helpful in differentiating uncomplicated and complicated appendicitis in children and could predict appendiceal perforation.

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“…Esta distinción, de enorme relevancia terapéutica y pronóstica, se confirma con el estudio histopatológico de la pieza de apendicectomía, aunque su estratificación de sospecha se establece con la impresión intraoperatoria reportada por el Cirujano Pediátrico durante la intervención. La evidencia existente en la literatura científica en relación al papel discriminatorio de los biomarcadores descritos entre estas dos entidades es muy limitada [53].…”

Section: Justificación Del Trabajounclassified

Valoración de la aplicabilidad clínica y de la rentabilidad diagnóstica de un panel de biomarcadores en sangre periférica en la apendicitis aguda pediátrica

Arredondo¹

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Background Despite the radiological and analytical advances of the last decades, there is still a significant rate of diagnostic error in pediatric acute appendicitis. In recent years, multiple biomarkers have emerged as potential diagnostic tools. This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis. Methods We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography (Medline, PubMed, Web of Science and SciELO). Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria. Methodological quality of the selected article was rated using the QUADAS2 index. Data extraction was performed by two independent reviewers. ResultsThe research in the medical bibliography databases resulted in 68 articles. We removed 26 duplicates. Among the remaining 42 articles, we excluded 33 following the inclusion and exclusion criteria. Of the final 9 studies included in this review, 8 provided measured serum interleukin-6 values, and all of them reported significant differences between groups, but inconsistent results regarding sensitivity and specificity. Conclusions The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited. The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis. There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis. The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis. We consider that this may be an avenue of research to explore in the future.

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Related Markers for the Precision Diagnosis of Complex Appendicitis in Children

Cited by 4 publications

References 83 publications

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children

Valoración de la aplicabilidad clínica y de la rentabilidad diagnóstica de un panel de biomarcadores en sangre periférica en la apendicitis aguda pediátrica

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