Coronavirus Disease 2019 (COVID-19) caused by a strain of SARS– CoV2. A lot of ministries chose mass lockdown protocol as a way to control the virus spread. One of the lockdown negative consequences is the impact of psychological status which includes a sense of boredom, confusion., psychological stress, anxiety, depression and physical effects. The purpose of this study was to assess and evaluate the effect of COVID-19 pandemic on the psychological status for Palestinian adults, and to establish recommendations in order to promote and maintain psychological well-being during this pandemic. A cross-sectional study was conducted among Palestinian adults, 739 participant with mean age 31.76 filled the on-line questionnaire. Around one-third of respondents revealed having many signs of anxiety and around 42% of respondents expressed having many depression signs. Females were significantly more likely to have many depression signs, while health care workers, those who deal directly with confirmed cases of Covid-19 and who assist in providing health care for a diagnosed Covid-19 patient were significantly less likely to have many depression signs compared to others. Regarding the participants’ income, those with increased income were significantly more likely to have almost no signs of depression compared to others. However, COVID-19 pandemic has a negative effect on the mental status, the majority of participants have signs of anxiety and depression