Relapsing Pustular Eruptions of the Hands and Feet.

Ashurst, Peter J.

doi:10.1111/j.1365-2133.1964.tb14502.x

Cited by 51 publications

(31 citation statements)

References 27 publications

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“…Another possible reason might be that the total number of cases was small and our coexistence rate of sacroilitis (23%) was lower than that of past studies (52% [21], 40% [11]). A strong correlation between PPP and psoriasis has been recognized [3]; however, Sugimoto et al stated that psoriasis should not be included as a skin lesion of SAPHO syndrome [27]. If PPP is added as a skin lesion to the criteria of spondyloarthropathy, 100 and 92% of our cases would fulfill the diagnostic criteria of ESSG [6] and Amor [2], respectively.…”

Section: Discussionmentioning

confidence: 87%

SAPHO syndrome associated spondylitis

et al. 2008

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The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.

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Section: Discussionmentioning

confidence: 87%

SAPHO syndrome associated spondylitis

et al. 2008

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“…The disease was defined according to Ashurst [2] as a pustular rash involving predominantly the midpalms and thenar eminences of the hands, and the heels and insteps on the feet. A questionnaire was sent to all these patients.…”

Section: Methodsmentioning

confidence: 99%

“…In the latter condi tion the subchondral bone defects were bizarre, larger, and the sclerotic surrounding was disorganized and diffuse ( fig. 4) as compared to the rounded lacunae of grades (1) and (2). Also, for the diagnosis of osteitis-osteochondritis, the presence of reactive bone thick ening at the edges of the synchondroses, anteriorly as well as posteriorly, due to reactive bone apposition, was regarded as an obligatory criterion.…”

Section: Radiological Investigationmentioning

confidence: 99%

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Pustulosis Palmoplantaris and Its Relation to Chronic Recurrent Multifocal Osteomyelitis

et al. 1979

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In a previous study we found that clavicular lesions in chronic recurrent multifocal osteomyelitis (CRMO) in young patients was associated with palmoplantar pustulosis (PPP). In this work the relationship between sternoclavicular lesions and PPP was studied in a group of adult patients. The sternoclavicular region of 52 patients with PPP and 25 control persons was examined by tomography. Among the PPP patients there were inflammatory lesions in the sternal synchondroses in 3 patients. There were no such lesions in the controls. In this unselected population of adult patients there was thus no definite association between PPP and sterno-clavicular lesions. In young patients on the other hand, CRMO with clavicular lesions may be another, probably noninfectious, cause of PPP.

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“…It is highly resistant to treatment. 11 The powerful immunosuppressive prepthyroid autoantibodies such as anti-thyroglobulin and antimicrosomal antibodies. The karyotypic examination of the aration for BMT may have modified the clinical course of PPP, and the patient showed a complete clearance of his bone marrow confirmed complete chimerism with donor cells.…”

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confidence: 99%

Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation

Kishimoto

Yamamoto

Ito

et al. 1997

Bone Marrow Transplant

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Summary:Case reportA 40-year-old man was diagnosed with AML in January We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular pso-1992. Bone marrow cytology revealed M6 by the FAB classification with trilineage myelodysplasia. The patient riasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-went into complete remission following induction chemotherapy with daunorubicin, 6-mercaptopurine, and behenoyl year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the cytosine arabinoside. After receiving three courses of consolidation chemotherapy, he developed skin lesions on the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of palms and soles ( Figure 1). The skin lesions were diagnosed as PPP by histological examination in February 1993. immunosuppressive therapy for over 2 years. However, he developed hyperthyroidism with anti-thyroglobulin They were treated with combinations of topical corticosteroids and etretinate, but showed only partial response. antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyrogloIn November 1993, after myeloablation with BU (16 mg/kg) and CY (120 mg/kg), the patient received an bulin antibodies before BMT. The donor had no history of thyroid diseases and showed normal thyroid funcallogeneic BMT from his HLA-identical younger sister, who did not suffer from PPP. The mixed lymphocyte reactions but was positive for anti-thyroglobulin antibodies. Thus, even when the donor is in a subclinical state, autotion was negative. Although the patient's elder sister had died of hyperthyroidism, his younger sister had no history immune thyroiditis may be transferred from donors to recipients by BMT.of thyroid diseases and showed normal thyroid functions, but was positive for anti-thyroglobulin antibodies. Keywords: autoimmune thyroiditis; palmoplantar pustular psoriasis; bone marrow transplantation; autoimmunity CYA and MTX were used for GVHD prophylaxis. The hematological follow-up showed stable engraftment with complete hematopoietic recovery and sustained complete chimerism. There were no signs of acute GVHD. After his It is well known that the hematopoietic and immune system of recipients is eventually replaced by donor-derived cells after allogeneic BMT. Experimental work in animal models has demonstrated that BMT can be used to treat systemic and organ-specific autoimmune diseases. 1 In humans, the resolution of immune-mediated diseases after BMT has recently been reported. [2][3][4] On the other hand, autoimmune diseases have also been transferred from donors to recipients in both mice 5 and humans 6-8 by BMT. We report the unusual case of a patient who was cured of palmoplantar pustular psoriasis (PPP) but developed autoimmune thyroiditis after allogeneic BMT. This is the first case report in which a pre-existing immune-mediated disease was cured while ...

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Relapsing Pustular Eruptions of the Hands and Feet.

Cited by 51 publications

References 27 publications

SAPHO syndrome associated spondylitis

SAPHO syndrome associated spondylitis

Pustulosis Palmoplantaris and Its Relation to Chronic Recurrent Multifocal Osteomyelitis

Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation

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