Relapsing polychondritis and eye disease.

McKay, D A; Watson, Peter; Lyne, A J

doi:10.1136/bjo.58.6.600

Cited by 44 publications

(10 citation statements)

References 11 publications

(1 reference statement)

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“…Patients with relapsing polychondritis (61) often suffer from anterior uveitis. Patients with polychondritis commonly display scleritis (61,62), and scleritis is also observed in rheumatoid arthritis (63). Thus, a primary immune response to cartilage proteoglycan could lead to a cross-reaction with immunologically related proteoglycans in other tissues of the kind described here .…”

Section: Poole Et Almentioning

confidence: 77%

Mammalian eyes and associated tissues contain molecules that are immunologically related to cartilage proteoglycan and link protein.

Poole¹,

Pidoux²,

Reiner³

et al. 1982

The Journal of Cell Biology

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Monospecific antibodies to bovine nasal cartilage proteoglycan monomer and link protein were used to demonstrate that immunologically related molecules are present in the bovine eye and associated tissues. With immunofluorescence microscopy, reactions for both proteoglycan and link protein were observed in the sclera, the anterior uveal tract, and the endoneurium of the optic nerve of the central nervous system . Antibody to bovine nasal cartilage proteoglycan also reacted with some connective tissue sheaths of rectus muscle and the perineurium of the optic nerve of the central nervous system . .Antibody to proteoglycan purified from rat brain cross-reacted with bovine nasal cartilage proteoglycan, indicating structural similarities between these proteoglycans. ELISA studies and crossed immunoelectrophoresis demonstrated that purified dermatan sulphate proteoglycans isolated from bovine sclera did not react with these antibodies but that the antibody to cartilage proteoglycan reacted with other molecules extracted from sclera . Two molecular species resembling bovine nasal link protein in size and reactivity with antibody were also demonstrated in scleral extracts : the larger molecule was more common . Antibody to link protein reacted with the media of arterial vessels demonstrating the localization of arterial link protein described earlier. Tissues that were unstained for either molecule included the connective tissue stroma of the iris, retina, vitreous body, cornea, and the remainder of the uveal tract. These observations clearly demonstrate that tissues other than cartilage contain molecules that are immunologically related to cartilage-derived proteoglycans and link proteins .

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Section: Poole Et Almentioning

confidence: 77%

Mammalian eyes and associated tissues contain molecules that are immunologically related to cartilage proteoglycan and link protein.

Poole¹,

Pidoux²,

Reiner³

et al. 1982

The Journal of Cell Biology

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“…Ocular adnexal involvement in the form of periorbital edema causing proptosis or extraocular muscle palsy from vasculitis affecting the muscle or its nerve supply may be seen [5,40,43]. Diffuse anterior scleritis is most common, though other types of scleritis including the necrotising variant have also been reported.…”

Section: Ocular Involvementmentioning

confidence: 99%

“…Common manifestations are scleritis, episcleritis and conjunctivitis [5,[39][40][41][42][43]. Ocular adnexal involvement in the form of periorbital edema causing proptosis or extraocular muscle palsy from vasculitis affecting the muscle or its nerve supply may be seen [5,40,43].…”

Section: Ocular Involvementmentioning

confidence: 99%

Relapsing polychondritis: a review

et al. 2013

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Relapsing polychondritis is a rare multisystem disease involving the cartilaginous and proteoglycan rich structures. The spectrum of clinical presentations may vary from intermittent episodes of painful and often disfiguring auricular and nasal chondritis, to occasional organ or even lifethreatening manifestations like airway collapse. There is lack of awareness about this disease due to its rarity. Relapsing polychondritis disease activity index has recently been validated and may help in clinical decision making and research. This article reviews the literature on this disease entity.

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“…Episcleritis, scleritis, uveitis, iritis, and keratoconjuctivitis sicca are the most common manifestations (10,11). Limbal scleritis leading to circumferential ulceration is usually devastating, difficult to treat, and can result in blindness due to corneal melting.…”

Section: Discussionmentioning

confidence: 98%