Relapsing polychondritis: A clinical review

Letko, Erik; Zafirakis, Panayotis; Baltatzis, Stefanos; Voudouri, Adamantia; Livir-Rallatos, Charalampos; Foster, C. Stephen

doi:10.1053/sarh.2002.32586

Cited by 231 publications

(204 citation statements)

References 72 publications

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“…Due to the inflammation in the cartilaginous portion of the pinna, pain, discoloration, or tenderness in this area is frequently seen as the initial symptom. As in our patient, after repeated attacks, the cartilaginous structure of the ear is damaged and assumes a nodular or verrucous appearance, loses shape, and becomes soft and flabby (1,3). Symptoms of vestibular dysfunction, as well as impaired hearing, occasionally occur.…”

Section: Discussionsupporting

confidence: 50%

“…Less severe symptoms, such as mild auricular or nasal chondritis and arthralgia, are generally treated with nonsteroidal antiinflammatory drugs. Organ-threatening disease, including severe polychondritis, ocular or laryngotracheal involvement, systemic vasculitis, and glomerulonephritis, require systemic corticosteroids and different immunosuppressants, such as methotrexate, cyclophosphamide, azathioprine, cyclosporine, and mycophenolate mofetil (1,3). After adding methotrexate (15 mg/week) to the treatment regimen due to the poor response to steroids in our patients, he was episode-free during his one-year follow-up.…”

Section: Discussionmentioning

confidence: 79%

“…In our case, knee joints were repeatedly affected during the course of the disease without any destruction. The joint involvement in RP is usually episodic, nonerosive asymmetric oligoarthritis, or polyarthritis and lasts for several weeks (1). Respiratory tract involvement is also seen frequently.…”

Section: Discussionmentioning

confidence: 99%

“…scleritis, episcleritis, and conjunctivitis) and dermatologic symptoms (e.g. erythema nodosum, erythema multiforme, panniculitis, purpura, livedo reticularis, and multiple neurologic abnormalities consistent with vasculitis) can occur during the course of RP (1). In around 30% of the cases, an association with other diseases especially systemic vasculitis or myelodysplatic syndrome is detected (3).…”

Section: Discussionmentioning

confidence: 99%

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Relapsing Polychondritis: Inflamed Joints and Ears

Melikoğlu

Şenel

2015

Balkan Med J

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Relapsing polychondritis (RP) is an episodic and progressive inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree (1). The spectrum of its presentations may vary from intermittent mild episodes of chondritis to occasional organ or even life-threatening manifestations. There is a lack of awareness about this disease due to its rarity. With this case presentation, our goal was to draw attention to this disease, which could be delayed for the diagnosis. CASE PRESENTATIONA 64 year-old male patient was referred to our department with bilateral knee pain. He also gave a several years history of episodic ear swelling, tenderness, tinnitus, and recurrent conjunctivitis. On physical examination, besides the bilateral knee arthritis, discoloration and deformity of the pinna were identified (Figure 1). In his medical history, similar recurrent arthritis, swelling, and erythema in his external ear were present. The test results were negative rheumatoid factor, anti nuclear antibody (ANA), Antineutrophil cytoplasmic anti-

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relapsing Polychondritis: Inflamed Joints and Ears

Melikoğlu

Şenel

2015

Balkan Med J

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“…5 The presenting symptoms can include hoarseness of voice, dysphonia, and respiratory distress. 6 Cartilage inflammation leads to laryngeal and tracheal collapse with secondary infection. 7 Apart from infection, a delay in diagnosing and treatment leads to tracheobronchomalacia and dynamic airway collapse.…”

Section: Discussionmentioning

confidence: 99%