Relapsing COVID-19 infection as a manifestation of Good syndrome: a case report and literature review

Wee, Liang En; Jinquan, Tan; Oon, Lynette Lin Ean; Pena, Angela Maria Takano; Quek, Jeffrey Kim Siang; Venkatachalam, Indumathi; Kwan-Ki, Karrie Ko; Wijaya, Limin

doi:10.1016/j.ijid.2022.12.040

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Very few cases of GS with COVID-19 have been reported since the onset of COVID-19. The majority had severe courses [ 8 , 14 – 17 ]. At least in two cases, a relapsing nature of disease has been reported.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study found that a patient initially tested positive for SARS-CoV-2, then tested negative within a week, and then tested positive again. Notably, the patient was infected with a SARS-CoV-2 variant that was prevalent five months ago and different from the circulating variant in the time of sampling [ 8 ]. Death rates continue to be high even with antimicrobial therapy and immunoglobulin replacement [ 14 , 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Severe, fatal and recurrent case reports of SARS-CoV-2 infections in patient suffering from GS have been reported during the COVID-19 pandemic [ 8 , 14 – 18 ]. In our case an unusual persistent infection of SARS-CoV-2 was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Detection of a strain belonging to delta variant which was dominant in Iran approximately one year before sample collection from our case suggests that he was infected with delta variant at least before Feb 2022 and his immune system was unable to clear the virus during this period of time. In a recent case report from Singapore, SARS-CoV-2 persistence was identified as identical SARS-CoV-2 strains were detected in respiratory specimens collected over the course of disease [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Persistent or relapsing SARS-CoV-2 infection has been recorded in immunocompromised individuals [ 6 , 7 ]. Recently, relapsing COVID-19 has been reported as a manifestation of GS [ 8 ]. Despite a few case reports of concurrent COVID-19 and GS, there is little data about the clinical features of COVID-19 and mutation analysis SARS-CoV-2 of in patients with GS.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and genomic evaluations of a persistent fatal SARS-CoV-2 infection in a goods syndrome patient: a case report

Tabarsi,

Maleki,

Abtahian

et al. 2024

BMC Infect Dis

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The coronavirus disease of 2019 (COVID-19) resulted from an infection by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) which is the main cause of acute respiratory distress syndrome (ARDS) in global population from 2019 on. It may contribute to higher rate of death among the patients with immunodeficiency based on recent reports. In addition, Good syndrome (GS) as a result of thymoma removal might cause in some long-lasting microbial infections. We described clinical aspects and viral mutations on a case of GS suffering from COVID-19. A 46-year-old man with fever, common respiratory disease symptoms and positive COVID-19 polymerase chain reaction (PCR) test, with the history of thymoma removal surgery was admitted to Masih Daneshvari Hospital, Tehran, Iran. Lung radiographs and oxygen saturation measurement disclosed considerable implication resulted in application of several anti-microbial medication. The delta variant (B.1.617.2 (21 J Clade)) was the strain isolated from the patient by sequencing methods done by the COVID-19 National Reference Laboratory (CNRL), Pasteur Institute of Iran, while the dominant strain circulated mostly among population was Omicron (B.1.1.529) at the time of sampling. Unfortunately, the patient had passed away a month later by sudden respiratory failure progressed in refractory septic shock. Despite the fact that opportunistic infections may lead the GS patients to a major health problematic condition, unusual persistent of infections such as non-dominant variant of SARS-Cov-2 could be observed through the disease timeline. Therefore, a fully screening of thymoma plus intra-host evolution monitoring of SARS-CoV-2 is highly recommended in immunocompromised patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and genomic evaluations of a persistent fatal SARS-CoV-2 infection in a goods syndrome patient: a case report

Tabarsi,

Maleki,

Abtahian

et al. 2024

BMC Infect Dis

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Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature

Ye,

Wang,

Bao

et al. 2024

Immunol Res

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Clinical and Genomic Evaluations of a persistent fatal SARS-CoV-2 infection in a Goods syndrome patient: A case report

Tabarsi

Maleki

Abtahian

et al. 2023

Preprint

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COVID-19 resulted from an infection by SARS-Cov-2 which is the main cause of ADRS in global population from 2019 on. It may contribute to higher rate of death among the patients with immunodeficiency based on recent reports. In addition, Good syndrome (GS) as a result of thymoma removal might cause in some long-lasting microbial infections. We described clinical aspects and viral mutations on a case of GS suffering from COVID-19. A 46-year-old man with fever, general respiratory signs and positive COVID-19 PCR test, with the history of thymoma removal surgery was admitted to Masih Daneshvari Hospital, Tehran, Iran. Lung radiographs and Oxygen saturation measurement disclosed considerable implication resulted in application of several anti-microbial medication. The delta variant (B.1.617.2 (21J Clade)) was the strain isolated from the patient by sequencing methods done by CNRL while the dominant strain circulated mostly among population was Omicron (B.1.1.529) at the time of sampling. Unfortunately, the patient had passed away a month later by sudden respiratory failure progressed in refractory septic shock. Despite the fact that opportunistic infections may lead the GS patients to a major health problematic condition, unusual persistent of infections such as non-dominant variant of SARS-Cov-2 could be observed through the disease timeline. Therefore, a fully screening of thymoma plus intra-host evolution monitoring of SARS-CoV-2 is highly recommended in immunocompromised patients.

show abstract

Relapsing COVID-19 infection as a manifestation of Good syndrome: a case report and literature review

Cited by 8 publications

References 11 publications

Clinical and genomic evaluations of a persistent fatal SARS-CoV-2 infection in a goods syndrome patient: a case report

Clinical and genomic evaluations of a persistent fatal SARS-CoV-2 infection in a goods syndrome patient: a case report

Good syndrome combined with multiple microbial pulmonary infections: case report and review of the literature

Clinical and Genomic Evaluations of a persistent fatal SARS-CoV-2 infection in a Goods syndrome patient: A case report

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