Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection

Caselli, Elisabetta; Borghi, Alessandro; Maritati, Martina; Gafà, Roberta; Lanza, Giovanni; Luca, Dario Di; Virgili, Annarosa; Contini, Carlo

doi:10.1186/s13027-016-0079-4

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…The association between Th 1 response impairment and C. pneumoniae infection may be also supported by increased incidence of bacterial DNA in patients with atopic dermatitis (12.5%) (Th 2 cytokines pattern) vs. psoriatic patients (2.5%) (Th 1 cytokines pattern) and healthy controls (0%) (immunocompetent individuals). C. pneumoniae DNA was detected only in one skin biopsy in our study group, in accordance with the results of German and Italian investigators, who not detected bacterial in the skin biopsies from MF/SS patients, and confirm that C. pneumoniae infection could not be estimated as a primary event in the pathogenesis of CTCL, in spite of Casselli et al case describing skin presence of Chlamydia spp (and HHV8) in all recurrences of CD30+CTCL as well as in routine control blood samples [45][46][47].…”

Section: Discussionsupporting

confidence: 92%

The Prevalence of Chlamydophila pneumoniae in the Blood Samples of Patients with Primary Cutaneous Lymphomas

Nedoszytko¹,

Pm²,

Karenko³

et al. 2017

J Transm Dis Immun

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Section: Discussionsupporting

confidence: 92%

The Prevalence of Chlamydophila pneumoniae in the Blood Samples of Patients with Primary Cutaneous Lymphomas

Nedoszytko¹,

Pm²,

Karenko³

et al. 2017

J Transm Dis Immun

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“…Clinical disease linked to this bacterium includes keratoconjunctivitis (3), and urogenital infections and infertility (31,32). Associations between different herpesviruses and Chlamydia infection have also been described epidemiologically for humans and cats (33)(34)(35)(36). In vitro coinfection studies of Chlamydia trachomatis and human herpesviruses have indicated complicated virus-host-bacterium interactions, including virus-induced chlamydial persistence (37,38) and an increase in viral entry into normally nonsusceptible cells infected with Chlamydia (37).…”

Section: Discussionmentioning

confidence: 99%

Detection and Differentiation of Two Koala Gammaherpesviruses by Use of High-Resolution Melt (HRM) Analysis Reveals Differences in Viral Prevalence and Clinical Associations in a Large Study of Free-Ranging Koalas

et al. 2019

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The iconic koala (Phascolarctos cinereus) is host to two divergent gammaherpesviruses, phascolarctid gammaherpesviruses 1 and 2 (PhaHV-1 and -2), but the clinical significance of the individual viruses is unknown and current diagnostic methods are unsuitable for differentiating between the viruses in large-scale studies. To address this, we modified a pan-herpesvirus nested PCR to incorporate highresolution melt analysis. We applied this assay in a molecular epidemiological study of 810 koalas from disparate populations across Victoria, Australia, including isolated island populations. Animal and clinical data recorded at sampling were analyzed and compared to infection status. Between populations, the prevalence of PhaHV-1 and -2 varied significantly, ranging from 1% to 55%. Adult and older animals were 5 to 13 times more likely to be positive for PhaHV-1 than juveniles (P Ͻ 0.001), whereas PhaHV-2 detection did not change with age, suggesting differences in how these two viruses are acquired over the life of the animal. PhaHV-1 detection was uniquely associated with the detection of koala retrovirus, particularly in females (P ϭ 0.008). Both viruses were significantly associated (P Ͻ 0.05) with the presence of genital tract abnormalities (uterine/ovarian cysts and testicular malformation), reduced fertility in females, urinary incontinence, and detection of Chlamydia pecorum, although the strength of these associations varied by sex and virus. Understanding the clinical significance of these viruses and how they interact with other pathogens will inform future management of threatened koala populations.

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“…Chlamydophila pneumoniae DNA was detected only in one skin biopsy in our study group, in accordance with the results of German and Italian investigators, who did not detect any bacterial DNA in skin biopsies from MF/SS patients, and confirm that C. pneumoniae infection could not be estimated as a primary triggering factor in the pathogenesis of CTCL, in spite of Casselli et al who had described skin presence of Chlamydia spp. (and HHV8) in all recurrences of CD30+CTCL as well as in routine control blood samples [ 45 – 47 ].…”

Section: Discussionmentioning

confidence: 99%

Presence of Chlamydophila pneumoniae DNA in blood cells is a frequent event in patients with the late stage of primary cutaneous lymphomas and with atopic dermatitis

Nedoszytko

Wierzbicki

Karenko

et al. 2018

pdia

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IntroductionMicrobial infection and associated super antigens have been implicated in the pathogenesis of cutaneous T-cell lymphoma (CTCL), and many patients die from complicating bacterial infections. It has been postulated that Chlamydophila pneumoniae (C. pneumoniae) infection may be involved in the pathogenesis of Mycosis fungoides (MF) but published data are limited and controversial.AimTo analyze the frequency of (C. pneumoniae) DNA presence in blood samples of lymphoma cases.Material and methodsUsing Q-PCR method we analyzed the presence of DNA in the blood samples obtained from 57 patients with CTCL (55 – mycosis fungoides (MF)/Sézary syndrome (SS), one primary cutaneous anaplastic large cell lymphoma (CD30+) and one NKT cell lymphoma) and 3 patients with cutaneous B-cell lymphomas, and 120 individuals from control groups (40 patients with psoriasis, 40 patients with atopic dermatitis and 40 healthy controls).Results Chlamydophila pneumoniae DNA was identified in 13 of 55 cases in the MF/SS group (23.6%), in 1 patient with CD30+ large cell lymphoma and in 1 of 3 patients with B-cell lymphoma. The presence of C. pneumoniae was confirmed in 1 of 40 psoriatic patients (2.5%), in 5 of 40 patients with atopic dermatitis (12.5%) and in none of 40 healthy individuals. Presence of C. pneumoniae DNA in MF patients was strongly associated with disease progression; rs = 0.756; p = 0.0123 for groups IA → IVB, and was noted more frequently in advanced (III + IV) stages than in early (I–II) stages (p = 0.0139). There are no differences in the mean age of MF/SS patients with and without infection.ConclusionsThe presence of C. pneumoniae DNA in the blood cells is a frequent event in late stages of MF/SS and may be explained by Th2 shift and suppression of the immune system during the course of the disease.

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Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection

Cited by 5 publications

References 36 publications

The Prevalence of Chlamydophila pneumoniae in the Blood Samples of Patients with Primary Cutaneous Lymphomas

The Prevalence of Chlamydophila pneumoniae in the Blood Samples of Patients with Primary Cutaneous Lymphomas

Detection and Differentiation of Two Koala Gammaherpesviruses by Use of High-Resolution Melt (HRM) Analysis Reveals Differences in Viral Prevalence and Clinical Associations in a Large Study of Free-Ranging Koalas

Presence of Chlamydophila pneumoniae DNA in blood cells is a frequent event in patients with the late stage of primary cutaneous lymphomas and with atopic dermatitis

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