Relapses after Thionamide Therapy for Graves' Disease

Holm, Lars‐Erik; Ålinder, Inger

doi:10.1111/j.0954-6820.1982.tb01987.x

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…Only a few small observational studies from the 1970s and 1980s have reported on the prognosis after ATD treatment in Sweden, and only a minority of the eligible patients had been treated with ATDs (7,19,20). The cumulative relapse rates were 44-53%.…”

Section: Introductionmentioning

confidence: 99%

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Mohlin

Nyström

Eliasson

2014

European Journal of Endocrinology

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Objective: To investigate the long-term prognosis of patients with Graves' disease (GD) after antithyroid drug (ATD) treatment and follow-up outside of highly specialised care. Design and methods: Medical records of all patients diagnosed with first-time GD in 2000-2010 with at least 6 months ATD treatment at a central hospital and follow-up in primary health care in the county of Norrbotten in northern Sweden were retrospectively reviewed. Patients were followed for relapse until 31st December 2012. We included 219 patients (mean age 46 years, 82.5% women) with follow-up of maximum 10 years and 829 observed patient years. Data were analysed using Kaplan-Meier estimates and log-rank test. Results: During the observation period, 43.5% of the patients had relapsed into active GD. The cumulative relapse rates were 22.6, 30.2, 36.9 and 41.5% after 6 months, 1, 3 and 5 years respectively. The presence of goitre (PZ0.014) predicted relapse. Previous smoking was protective against relapse (PZ0.003). The levels of free thyroxine or free tri-iodothyronine, age, gender, current smoking and ophthalmopathy did not predict relapse. Agranulocytosis was found in 1.7% (95% CI 0.7-4.0%). Conclusion: A long-term remission of 56.5%, in an iodine-sufficient area where ATD is offered to most patients in the real world of central and district hospitals, is higher than in most studies. Relapse was most common during the first year, and prognosis was excellent after 4 years without relapse. The protective effect of previous smoking merits further research.

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Section: Introductionmentioning

confidence: 99%

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Mohlin

Nyström

Eliasson

2014

European Journal of Endocrinology

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The Thyroid Gland

Bürgi¹

1986

Clinical Endocrinology

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Comparison of RA 131I treatment protocols for Graves’ disease

DeGroot

Mangklabruks²,

McCormick³

1990

J Endocrinol Invest

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The efficacy of 131I therapy in achieving euthyroidism has been studied in a group of 264 patients followed for up to 10 yr. One hundred and eighty-six were given a dose adjusted for thyroid size and radioactive iodine uptake (Protocol 1), and a second group received the same dosage followed by antithyroid drug therapy plus potassium iodide for 15 days (Protocol 2). At 10-yr follow-up, 50-60% of patients were euthyroid. 25-29% of patients required 2 doses of 131I, and 4-5% required 3 doses. Fewer patients became hypothyroid when their pretreatment FTI was above the average value. More patients became hypothyroid, if their pretreatment test for antimicrosomal antibodies was positive. Patients who required a second dose of radioactive iodide had a significantly greater chance of having worsening of their ophthalmopathy than those who became hypothyroid after the first dose. Treatment with radioactive iodide under either protocol appears to achieve euthyroidism at 10 yr with an incidence higher than that achieved by antithyroid drugs and comparable to that reported for subtotal thyroidectomy.

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Relapses after Thionamide Therapy for Graves' Disease

Cited by 6 publications

References 14 publications

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

Long-term prognosis after medical treatment of Graves' disease in a northern Swedish population 2000–2010

The Thyroid Gland

Comparison of RA 131I treatment protocols for Graves’ disease

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