Background: Colorectal Cancer (CRC) is the third most common cancer worldwide. Despite adequate treatment late relapses (beyond 5 years follow-up) may occur. FDG-PET/TC may be useful in this setting.Case: A 48 year-old women underwent curative treatment for a stage IIIA mucinous colon cancer with signet-cell variant. 20 years later, a bulky retroperitoneal mass is evidenced by CT scan in the context of a new-onset toxic syndrome and hip pain. First biopsy is diagnostic for carcinoma and a FDG-PET/TC is performed with the aim to identify a primary tumour and rule out further disease and turns out futile. A second biopsy of the mass is diagnostic for mucinous adenocarcinoma of colorectal origin. Deemed unrespectable, palliative treatment is offered and the patient dies 13 months after diagnosis.
Conclusion:Despite its usefulness in most cancers, FDG-PET/CT should be avoided in mucinous cancers.