Relapse with isolated peritoneal metastasis in lung adenocarcinoma: and review of the literature

Abstract

Lung cancer rarely involves the peritoneum without involvement of other metastatic sites. The most common regions of metastasis are the pleura, lung parenchyma, skeletal system, liver, brain, and adrenal glands. Compared with pleural metastasis, peritoneal involvement is rarely encountered in lung carcinoma. Ascites development is often described during late stages of the disease, following diagnosis in patients with serosal involvement other than pleural metastases. Diagnosis is based on histopathological or cytological examination confirmed by the presence of malign cells in the peritoneal fluids. Metastatic involvement of other areas is common and expected in cancer patients in whom peritoneal metastasis develop. There are no pulished reports of lung cancer cases with involvement of only the peritoneum without metastases to other more common regions. Herein we present a rare case of non-small cell lung carcinoma involving the peritoneum. The presented case had an unusual course and relapsed with peritoneal carcinomatosis without involvement of other regions.

A case report of lung adenocarcinoma with polyserous effusions as the onset symptom

“…According to the cases reported in the literature, metastatic ascites generally occurs in the late stage of disease, later than pleural effusion and pericardial effusion. [10] Metastatic ascites as the onset symptom was reported in only four of the 30 lung cancer cases reported by Su et al [15] In the case reported herein, lung cancer of the patient was already in the late stage, pathologically classified as adenocarcinoma with simultaneous occurrence of metastatic ascites, bilateral pleural effusion, and pericardial effusion, which is very rarely seen in clinical practice.…”

“…Unilateral or bilateral pleural effusion and pericardial effusion are more frequently seen malignant serous effusions in lung cancer as compared with metastatic ascites. [10,11] The reported autopsy detection rate of metastatic ascites in lung cancer is 2.7% to 16%, [12,13] while Satoh et al [14] only reported 12 (1.2%) cases of metastatic ascites in their 1041 lung cancer cases based on their 26-year statistical data. Su et al [15] reported only 30 cases of metastatic ascites in their 16-year statistics based on all general hospitals in Taiwan.…”

“…Although 2 of their 30 patients benefited from gefitinib treatment, they only survived 203 and 343 days respectively. Tanriverdi et al [10] reported a lung cancer patient with simple peritoneal metastasis and ascites, whose condition continued to progress after 2-week treatment with cisplatin/gemcitabine, and died 1 week after second-line treatment with radiotherapy and taxinol. The patient in our case has survived more than a year since the confirmed diagnosis of the disease and subsequent chemotherapy.…”

ROS1-rearranged lung adenocarcinoma with peritoneal carcinomatosis on initial presentation

“…The most common histological type associated with the peritoneal metastasis is adenocarcinoma 5. Many patients with PC have malignant pleural effusions suggesting that peritoneal spread may be related to serosal communication with metastatic seeding, however, cases of isolated PC without pleural or other site metastasis have been reported 6 9. It has been suggested that oncogene status of the tumour can influence the patterns of metastatic spread 7.…”

Patient with Three EGFR Mutations – Gradual Development of Resistance to Previous Targeted Treatment

“…nění [21,22]. Jejich přítomnost je spojena s horší prognózou pa cientů [21] a stejně jako u naší nemocné jsou obvykle spojeny s pohrudničními maligními výpotky [14].…”