Relación entre el hipotiroidismo y el hígado graso no alcohólico en una población española

Escudé, Alba Martínez; Pera, Guillem; Arteaga, Ingrid; Expósito, Carmen Barranco; Rodríguez, Lluis; Caballería, Llorenç

doi:10.1016/j.medcli.2019.03.018

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…Besides these data, a recent Spanish retrospective population study of 10,116 individuals found hypothyroidism in 9.1% of NAFLD patients with no significant differences with respect to controls, according to the presence of NAFLD [195].…”

Section: Resultsmentioning

confidence: 99%

“…EndocrinopathiesPolycystic ovarian syndromeHypothyroidismObesity and IR are common risk factors for both PCOS and NAFLD [207,208,209,210]. The prevalence of NAFLD is higher in patients with hypothyroidism; furthermore, low thyroid function seems to worsen the progression of liver damage, while replacement therapy may improve liver function [187,188,189,194,195,196,197]. Emerging LinkagesOsteoporosisNAFLD is associated with a 2.5-fold risk of osteoporotic fractures [122,124,125].…”

Section: Table A1mentioning

confidence: 99%

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NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

103

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.

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Section: Resultsmentioning

confidence: 99%

Section: Table A1mentioning

confidence: 99%

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

103

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“…8 Although there is a growing body of evidence indicating a potential association between hypothyroidism and NAFLD, 9 recent population-based evidence showed conflicting results. 10 Currently, there are no large-scale population-based data from Germany on the effect of thyroid gland disorders on incident NAFLD available.…”

Section: Introductionmentioning

confidence: 99%

Impact of thyroid disorders on the incidence of non‐alcoholic fatty liver disease in Germany

Labenz

Kostev²,

Armandi

et al. 2021

UEG Journal

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Background Studies investigating a potential association between hypothyroidism and non‐alcoholic fatty liver disease (NAFLD) showed conflicting results and large‐scale population‐based data from Germany on this topic are currently missing. Objective It was the aim of this analysis to investigate the impact of thyroid gland disorders on the prevalence of NAFLD in Germany. Methods In this case‐control study, using the German disease Analyzer database (IQVIA), NAFLD patients were matched to patients without NAFLD by age, sex, index year, treating physician, diabetes mellitus type II, and obesity. The main outcome of the study was an association between thyroid gland disorders (hypothyroidism, hyperthyroidism and autoimmune thyroiditis) and incident NAFLD and was evaluated using logistic regression analyses. Results 57,483 patients with NAFLD were matched to 57,483 patients without liver disease. Mean age of the cohort was 60.3 years (±14.1) and 52.3% were men. In regression analyses, hypothyroidism (OR 1.17, 95% CI 1.10 ‐ 1.24, p < 0.001) as well as autoimmune thyroiditis (OR 1.53, 95% CI 1.35–1.73, p < 0.001) were associated with a higher risk of NAFLD. In contrast, hyperthyroidism was associated with a lower risk of NAFLD (OR 0.85, 95% CI 0.77–0.94, p < 0.001). The effect of hypothyroidism on the prevalence of NAFLD remained significant across men (OR 1.31, 95% CI 1.15–1.48) as well as women (OR 1.12, 95% CI 1.05–1.21). Conclusion Hypothyroidism seems to be a risk factor for incident NAFLD.

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“…It has recently been suggested that thyroid hormones may influence the development of NAFLD and the progression of liver fibrosis [4]. In some studies, hypothyroidism has been associated with NALFD independently of other factors [5], however, this relationship was not found in a recently published study including a large number of subjects [6]. On the other hand, the association between low thyroid function and liver fibrosis has also been studied, although this is still controversial [7,8].…”

Section: Introductionmentioning

confidence: 99%

Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects

Escudé

Pera

Rodríguez

et al. 2021

JCM

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Alterations in thyroid function may contribute to the development of liver fibrosis especially in subjects with non-alcoholic fatty liver disease. This study aimed to investigate the risk of liver fibrosis according to low-normal thyroid function in the general population. We performed a descriptive cross-sectional study in subjects from 18–75 years randomly selected from 16 primary health care centers from 2017–2019. Each subject underwent clinical evaluation, physical examination, blood analysis and transient hepatic elastography. Descriptive and multivariate logistic regression analyses were used to identify factors associated with fibrosis. We included 1096 subjects (60 ± 11 years; 61% women); 70% had strict-normal thyroid function and 30% had low-normal thyroid function. Low-normal thyroid function was associated with a higher liver stiffness (LS) values: 5.2 vs. 4.8 kPa (p = 0.001) and a greater prevalence of fibrosis: 6.1 vs. 3% (p = 0.016) and 4.3 vs. 2.1% (p = 0.044) for the cut-off points of ≥8.0 kPa and ≥9.2 kPa, respectively. After adjustment for potential confounding factors, the risk of fibrosis in subjects with low-normal thyroid function was OR 1.54 (p = 0.213). In conclusion, low-normal thyroid function is associated with higher LS values and a greater risk of liver fibrosis in the general population, being dependent on other metabolic factors.

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Relación entre el hipotiroidismo y el hígado graso no alcohólico en una población española

Cited by 7 publications

References 28 publications

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Impact of thyroid disorders on the incidence of non‐alcoholic fatty liver disease in Germany

Risk of Liver Fibrosis According to TSH Levels in Euthyroid Subjects

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