Relación entre concentraciones de proteína C reactiva y recurrencia precoz de la fibrilación auricular tras cardioversión eléctrica

Zarauza, Jesús; Lera, María J. Rodríguez; Álvarez, Carlos Forcadell; Hernando, Juan P.; Ceballos, Begoña; Gutiérrez, Benedicto; Pérez, Josefina; Cuesta, Jose María Luzón

doi:10.1157/13084639

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…In the present study, patients with hs-CRP levels >1.85 mg/dl on the 2nd day after CV had an increased risk of AF relapse. According to previous studies, patients who experienced AF relapse had higher basal hs-CRP levels than those who remained in sinus rhythm during the follow-up period [11,12,14]. hs-CRP levels, both before and after DCCV, have clinical relevance in discerning which patients have an increased risk of AF relapse.…”

Section: Discussionmentioning

confidence: 97%

“…Although an association between inflammation and AF is undoubtedly present, it is still unclear whether inflammation is a cause or merely a consequence of AF [9]. In the past few years, several clinical trials have examined clinical inflammatory biomarkers that predict the success of CV and the maintenance of sinus rhythm [10,11,12,13,14,15,16]. Studies focused on high-sensitivity C-reactive protein (hs-CRP) have shown that hs-CRP levels are increased in AF patients compared to healthy control subjects [17,18].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Sinus Rhythm Restoration on High-Sensitivity C-Reactive Protein Levels and Their Association with Long-Term Atrial Fibrillation Recurrence after Electrical Cardioversion

Çelebi¹,

Celebi²,

Canbay³

et al. 2011

Cardiology

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Objective: Recent studies have shown that high-sensitivity C-reactive protein (hs-CRP) measured before cardioversion (CV) plays a significant role in predicting atrial fibrillation (AF) relapse. The time course of changes in hs-CRP after successful electrical CV remains controversial. The aim of the present study was to assess the prognostic value of pre- and post-CV hs-CRP levels in predicting the long-term risk of AF. Additionally, we evaluated changes in hs-CRP levels over time following a successful CV. Methods: This prospective study comprised 216 patients with persistent AF who underwent CV (mean age 51.94 ± 8.07 years; 55.6% men). hs-CRP levels were examined in all patients, and blood samples were taken prior to and 1, 2, 7 and 30 days after CV. AF relapse was determined by 24-hour ambulatory electrocardiogram (ECG) monitoring and 12-lead standard ECG during 12 months of follow-up. We further divided the study population into two groups according to their rhythm at the end of the follow-up period (group A: patients with AF at the end of follow-up; group B: patients with sinus rhythm at the end of the follow-up period). Results: The AF recurrence rate was 42.2% throughout the 12-month follow-up period. The basal hs-CRP levels were higher in patients with an AF relapse than in those without (1.68 ± 0.57 vs. 1.12 ± 0.53 mg/dl; p < 0.01). The hs-CRP levels were significantly decreased at 30 days in group B, whereas there was no significant decrease in group A (from 1.12 ± 0.53 to 0.69 ± 0.33 mg/dl, p < 0.01, and from 1.68 ± 0.57 to 1.69 ± 0.76 mg/dl, p > 0.05, respectively). By multivariate Cox analysis, the independent predictors of AF relapse time points were the basal and day-2 hs-CRP levels. Receiver operating characteristic curve analysis showed that the cutoff value of hs-CRP on the 2nd day for predicting AF relapse was 1.85 mg/dl, with a sensitivity of 62%, a specificity of 82%, a positive predictive value of 85.7% and a negative predictive value of 81.6%. Conclusion: The hs-CRP levels both prior to and after CV predict the long-term risk of AF relapse. In the present study, hs-CRP levels were significantly decreased in patients who remained in sinus rhythm at the end of the study. In contrast, hs-CRP levels remained high throughout the follow-up in patients with an AF relapse.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The Effect of Sinus Rhythm Restoration on High-Sensitivity C-Reactive Protein Levels and Their Association with Long-Term Atrial Fibrillation Recurrence after Electrical Cardioversion

Çelebi¹,

Celebi²,

Canbay³

et al. 2011

Cardiology

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show abstract

“…Case-control studies have demonstrated a correlation between the levels of CRP and the result of electrical cardioversion (8). In a study from the group of Rotter et al (9), patients that maintained sinus rhythm at 3 months after radiofrequency catheter ablation showed a significant decrease in CRP levels.…”

Section: See Page 1642mentioning

confidence: 99%

Atrial Fibrillation and C-Reactive Protein

Madrid¹,

Moro

2007

Journal of the American College of Cardiology

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“…Las concentraciones > 10 mg/l deben ser repetidas para descartar cualquier inflamación aguda y, en caso de ser persistentes, considerar una etiología no cardiovascular. En el estudio de Zarauza et al 7 cabe destacar que, como se deduce de los datos presentados, prácticamente todos los pacientes presentaban cifras < 10 mg/l.…”

Section: Guías Clínicas Y Pcrunclassified

“…En estudios de caso-control se ha demostrado una correlación entre las concentraciones de PCR y el resultado de la cardioversión 6 . Es en este contexto donde se enmarca el artículo de Zarauza et al 7 , publicado en este número de REVISTA ESPAÑOLA DE CARDIOLOGÍA.…”

Section: Introductionunclassified

Proteína C reactiva y fibrilación auricular. Un viejo marcador en busca de un nuevo sitio

Madrid

2006

Revista Española de Cardiología

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Relación entre concentraciones de proteína C reactiva y recurrencia precoz de la fibrilación auricular tras cardioversión eléctrica

Cited by 16 publications

References 23 publications

The Effect of Sinus Rhythm Restoration on High-Sensitivity C-Reactive Protein Levels and Their Association with Long-Term Atrial Fibrillation Recurrence after Electrical Cardioversion

The Effect of Sinus Rhythm Restoration on High-Sensitivity C-Reactive Protein Levels and Their Association with Long-Term Atrial Fibrillation Recurrence after Electrical Cardioversion

Atrial Fibrillation and C-Reactive Protein

Proteína C reactiva y fibrilación auricular. Un viejo marcador en busca de un nuevo sitio

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