Relação entre infecção pelo SARS-CoV-2 e fertilidade masculina: o que é conhecido?

Lins, José Jefferson da Silva Cavalcanti; Gomes, Lucas dos Santos; Arruda, Mariana Vitória Souza; Neto, Placido de Carvalho Silva; Leite, Renan Amorim; Alencar, Marília Gabriela Mendes de; Luna, Valda Lúcia Moreira; Galvão, Pauliana Valéria Machado; Conrado, George Alessandro Maranhão; Ferraz, Breno Gusmão

doi:10.33448/rsd-v11i12.34670

Cited by 1 publication

(2 citation statements)

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“…It is recognized that certain viruses can negatively impact male fertility, albeit the precise mechanisms remain incompletely understood (Lins et al, 2022). An array of microorganisms, spanning bacteria, viruses, and protozoa, may infiltrate the male reproductive tract, leading to seminal quality deterioration.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of SARS-CoV-2 infection, the heightened expression of angiotensin-converting enzyme 2 (ACE2) in Leydig cells, Sertoli cells, and germ cells renders the testes highly susceptible to SARS-CoV-2 infection and resultant damage (Lins et al, 2022). While two studies within the existing literature detected viral RNA in the semen of patients, the prevalence of such instances remained limited.…”

Section: Discussionmentioning

confidence: 99%

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The impact of COVID-19 on male reproductive health: a Systematic Review

Anastácio,

Monteiro,

Capelo

2024

JBRA

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Objective: This systematic literature review aims to assess the impact of COVID-19 on male fertility Data Sources: The study draws upon data extracted from PubMed, SciELO, and LILACS databases.Study Selection: The review incorporates crosssectional studies, cohort studies, and clinical trials, encompassing investigations related to the subject matter. The studies included were published between June 2020 and March 2023, and encompassed content in English, Portuguese, and Spanish. Exclusion criteria encompassed review articles, case reports, abstracts, studies involving animal models, duplicate articles, and letters to the editor.Data Collection: Data extracted included the author's name and publication year, the number of patients studied, patient age, the presence of COVID-19 in semen, observed hormonal changes, and alterations in seminal quality.Conclusions: While hormonal changes and a decline in seminal quality were observed in COVID-19 patients, the virus itself was not detected in semen in the analyzed articles, which contradicts certain findings in the existing literature. It is essential to note that methodologies in the studies were diverse, and, due to the novelty of this infection, it is premature to definitively ascertain its long-term effects on male fertility or whether fertility can recover after a period of convalescence. This underscores the necessity for further research, utilizing more robust methodologies such as cohort studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%