Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold

Guo, Jiasong; Su, Huanxing; Zeng, Yuan-Shan; Liang, Yu‐Xiang; Wong, Wai Man; Ellis-Behnke, Rutledge; So, Kwok‐Fai; Wu, Wutian

doi:10.1016/j.nano.2007.09.003

Cited by 210 publications

(175 citation statements)

References 50 publications

(72 reference statements)

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“…The nanostructured matrices may act as physic and chemical barriers for the infl ammatory cells preventing their gathering at the injury site and, as a consequence, their subsequent chemotactic action for other cells involved in the infl ammatory reaction. Similar hypotheses of the self-assembling nervous regenerative potential were formulated by Ellis-Behnke and Stupp in their most recent works in spinal cord regeneration (Guo et al 2007;Tysseling-Mattiace et al 2008).…”

Section: Nanobiomaterials In Tissue Engineeringsupporting

confidence: 53%

“…Industrial nanotechnology research developed various fabrication methods for obtaining nanofi bers: drawing, phase separation, melt-blowing, template synthesis, electrospinning, and self-assembly. However, only electrospinning and self-assembly achieved a widespread usage for regenerative medicine approaches thanks to their versatility and fascinating potential Guo et al 2007;Panseri et al 2008;Tysseling-Mattiace et al 2008). Research efforts deploying these two nanotechnology techniques are indeed focused on investigating their potential for tissue engineering of cartilage, bone, nerve, skeletal muscle, and skin and blood vessels (Yoshimoto et al 2003;Zong et al 2005;Riboldi et al 2008).…”

Section: Nanofi Ber Scaffoldsmentioning

confidence: 99%

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Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

Gelain¹

2008

IJN

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Over the last decades, tissue engineering has demonstrated an unquestionable potential to regenerate damaged tissues and organs. Some tissue-engineered solutions recently entered the clinics (eg, artifi cial bladder, corneal epithelium, engineered skin), but most of the pathologies of interest are still far from being solved. The advent of stem cells opened the door to large-scale production of "raw living matter" for cell replacement and boosted the overall sector in the last decade. Still reliable synthetic scaffolds fairly resembling the nanostructure of extracellular matrices, showing mechanical properties comparable to those of the tissues to be regenerated and capable of being modularly functionalized with biological active motifs, became feasible only in the last years thanks to newly introduced nanotechnology techniques of material design, synthesis, and characterization. Nanostructured synthetic matrices look to be the next generation scaffolds, opening new powerful pathways for tissue regeneration and introducing new challenges at the same time. We here present a detailed overview of the advantages, applications, and limitations of nanostructured matrices with a focus on both electrospun and self-assembling scaffolds.

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Section: Nanobiomaterials In Tissue Engineeringsupporting

confidence: 53%

Section: Nanofi Ber Scaffoldsmentioning

confidence: 99%

Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

Gelain¹

2008

IJN

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“…Therefore, it is likely that inflammation attenuation was a major contributor to the behavioral improvement observed. In another example, after sciatic axotomy, a 10 mm gap between the nerve stumps was filled with RADA16-1 hydrogels [60,61]. The supramolecular nature of the gels allowed the lesion to be completely filled and facilitated full contact with the 'stump', promoting the two-way migration of cells (Fig.…”

Section: Neural Applicationsmentioning

confidence: 99%

Self-Assembled Peptides: Characterisation and In Vivo Response

Nisbet

Williams

2012

Biointerphases

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The fabrication of tissue engineering scaffolds is a well-established field that has gained recent prominence for the in vivo repair of a variety of tissue types. Recently, increasing levels of sophistication have been engineered into adjuvant scaffolds facilitating the concomitant presentation of a variety of stimuli (both physical and biochemical) to create a range of favourable cellular microenvironments. It is here that self-assembling peptide scaffolds have shown considerable promise as functional biomaterials, as they are not only formed from peptides that are physiologically relevant, but through molecular recognition can offer synergy between the presentation of biochemical and physio-chemical cues. This is achieved through the utilisation of a unique, highly ordered, nano- to microscale 3-D morphology to deliver mechanical and topographical properties to improve, augment or replace physiological function. Here, we will review the structures and forces underpinning the formation of self-assembling scaffolds, and their application in vivo for a variety of tissue types.

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“…Because peptides are synthesized from amino acids, the degradation of the peptidebased scaffolds would lead to no immune response and side effects (Kopecek and Yang 2009;Zhao et al 2010). Moreover, these reported self-assembly peptide nanofiber scaffolds are with high water content, mimicking the natural extracellular matrix, and have been shown to be useful in 3D cell culture, tissue repair, and regeneration (Collier et al 2010;EllisBehnke et al 2006a, b;Guo et al 2007;Kopecek and Yang 2009;Ling et al 2011;Zhao et al 2010). One interesting application is to engineer the peptide molecules with side chains of pharmaceutical effects (Zhao et al 2010), and the hydrogel during biological degradation will guide the drug release reactions.…”

Section: Nano-gelmentioning

confidence: 99%

Nanomaterials in controlled drug release

Cai

2011

Cytotechnology

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In past years with the advances of chemistry and material sciences, the development of nanotechnology brought generations of nanomaterials with specific biomedical properties. These include the nanoparticle-based drug delivery, nanosized drugs, and nanomaterials for tissue engineering. The present article focuses on the use of nanomaterials in controlled drug release. The applications of nanomaterials with nanoenabled drug release characteristics brought many benefits when compared to the traditional (bulk) materials. We discuss the current advances and propose some future directions for the technology development.

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Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold

Cited by 210 publications

References 50 publications

Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

Novel opportunities and challenges offered by nanobiomaterials in tissue engineering

Self-Assembled Peptides: Characterisation and In Vivo Response

Nanomaterials in controlled drug release

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