Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy

Zhu, Liang; Dong, Chuanming; Sun, C. P.; Ma, Rongjie; Yang, Danjing; Zhu, Hongwen; Xu, Jun

doi:10.1016/j.bbrc.2015.06.174

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…In response to a complex combination of signaling pathways, NSCs differentiate into various specific cell types locally in the central nervous system (CNS), like neurons, astrocytes, and oligodendrocytes[ 24 ]. NSCs in humans maintain brain homeostasis and it continuously replenishes new neurons, which are important for cognitive functions[ 25 , 26 ]. However, there is now strong evidence for the aging-associated cognitive deficits, such as olfactory dysfunction, spatial memory deficits, and neurodegenerative disorders, which are caused by deterioration of NSC proliferation and differentiation and enhanced NSC senescence as a consequence of aging[ 27 , 28 ].…”

Section: Diseases Of Aging From Old Stem Cellsmentioning

confidence: 99%

Effect of aging on stem cells

Ahmed

Sheng

Wasnik

et al. 2017

WJEM

147

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Pluripotent stem cells have the remarkable self-renewal ability and are capable of differentiating into multiple diverse cells. There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered. Accordingly, it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders. Understanding the role of the aging process in deterioration of stem cell function is crucial, not only in understanding the pathophysiology of aging-associated disorders, but also in future development of novel effective stem cell-based therapies to treat aging-associated diseases. This review article first focuses on the basis of the various aging disease-related stem cell dysfunction. It then addresses the several concepts on the potential mechanism that causes aging-related stem cell dysfunction. It also briefly discusses the current potential therapies under development for aging-associated stem cell defects.

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Section: Diseases Of Aging From Old Stem Cellsmentioning

confidence: 99%

Effect of aging on stem cells

Ahmed

Sheng

Wasnik

et al. 2017

WJEM

147

View full text Add to dashboard Cite

show abstract

“…Moreover, stem cell research revealed, that autophagy plays a critical role in maintaining cellular stemness by regulating the mitochondrial content to help cellular adaptation to different metabolic requirements, and by reducing the accumulation of damaged mitochondria and reactive oxygen species (ROS) ( Chang, 2020 ). Cellular stemness represents an extraordinal capability of self-renewal and escaping aging ( Zhu et al, 2015 ). In stem cells the activity of the autophagic process is remarkably elevated which indicates a crucial role for stemness phenotype maintenance ( Chang, 2020 ; Adelipour et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…In stem cells the activity of the autophagic process is remarkably elevated which indicates a crucial role for stemness phenotype maintenance ( Chang, 2020 ; Adelipour et al, 2022 ). Several studies have shown that induction of autophagy can accomplish rejuvenation of quiescent stem cells that can restore age-related molecular and functional features both in vitro and in vivo ( Figures 1D–E ; Chen et al, 2009 ; Zhu et al, 2015 ; Leeman et al, 2018 ; Fang et al, 2020 ; Navarro Negredo et al, 2020 ; Park et al, 2021 ; Tan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Fountain of youth—Targeting autophagy in aging

Danics

Abbas

Kis

et al. 2023

Front. Aging Neurosci.

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As our society ages inexorably, geroscience and research focusing on healthy aging is becoming increasingly urgent. Macroautophagy (referred to as autophagy), a highly conserved process of cellular clearance and rejuvenation has attracted much attention due to its universal role in organismal life and death. Growing evidence points to autophagy process as being one of the key players in the determination of lifespan and health. Autophagy inducing interventions show significant improvement in organismal lifespan demonstrated in several experimental models. In line with this, preclinical models of age-related neurodegenerative diseases demonstrate pathology modulating effect of autophagy induction, implicating its potential to treat such disorders. In humans this specific process seems to be more complex. Recent clinical trials of drugs targeting autophagy point out some beneficial effects for clinical use, although with limited effectiveness, while others fail to show any significant improvement. We propose that using more human-relevant preclinical models for testing drug efficacy would significantly improve clinical trial outcomes. Lastly, the review discusses the available cellular reprogramming techniques used to model neuronal autophagy and neurodegeneration while exploring the existing evidence of autophagy’s role in aging and pathogenesis in human-derived in vitro models such as embryonic stem cells (ESCs), induced pluripotent stem cell derived neurons (iPSC-neurons) or induced neurons (iNs).

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Autophagy and Stem Cells

Yang

2018

Stem Cell Biology and Regenerative Medicine

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Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy

Cited by 6 publications

References 21 publications

Effect of aging on stem cells

Effect of aging on stem cells

Fountain of youth—Targeting autophagy in aging

Autophagy and Stem Cells

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