Rejection of injectable silicone “Bioplastique” used for vocal fold augmentation

Abstract

A rare case of repeated granulomatous inflammation after silicone injection laryngoplasty for vocal fold immobility as well as its treatment by endoscopic approach is reported. The patient presented a right-sided vocal fold immobility after laryngeal trauma and remained dysphonic despite of logopedic voice therapy because of severe glottal insufficiency. An endoscopic transoral intrafold silicone injection was applied to improve the vocal function. Silicone granuloma inflammation was observed 8 days after the vocal fold augmentation. Oral broad-spectrum antibiotics and corticosteroids did not improve the inflammation. A cordotomy was performed to remove the silicone implant. After 3 months, a second endoscopic surgical intervention was necessary to remove a recurrent silicone granuloma. Eight months after the second surgical intervention, the inflammation had disappeared. An autologous fat injection to restore the glottal closure was performed successfully. Type IV contact allergy was excluded with an epicutaneous patch and scratch test with components of the silicone implant. Clinical and treatment observations are reported and the literature on complications of intrafold injected silicone for vocal fold augmentation is reviewed.

The effect of bioreactor induced vibrational stimulation on extracellular matrix production from human derived fibroblasts

“…In challenging cases where voice therapy or traditional surgical practices are not successful in restoring speech, the repair or replacement of the damaged tissue with a graft is needed. Current surgical repair techniques utilizing various synthetic materials have their limitations [1,2], which is why the development of an engineered replacement tissue deserves consideration. We believe that the development of such a graft will be facilitated by an understanding of the factors that influence tissue assembly in vitro.…”

Therapy of Unilateral Vocal Fold Paralysis With Polydimethylsiloxane Injection Laryngoplasty: Our Experience

“…Nevertheless, a case of rejection of Vox-Impants used for vocal fold augmentation is reported 8 days after injection. 29 In that case, a granuloma for a foreign-body reaction occurred. Granulomatous reactions in soft tissue are also mentioned after injections of cosmetic fillers with PDMS suspended in PVP.…”

Umbilical Hernia—A Potential Donor-Site Complication of Fat Injection Laryngoplasty

“…However, when an inappropriate quantity or injection site is selected, the procedure may result in granuloma formation, vocal fold stiffness, an interrupted mucosal wave, or abscess formation in the vocal folds. 6,10,16 Surgical removal of the implant would be required if the injection was not carried out correctly. Alternatively, reabsorbable (temporary) fillers have the potential advantage of being biomechanically similar to the tissues surrounding the injected site; however, impermanency is inappropriate for laryngoplasties that require a long-term effect.…”