Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid

Caprile, Teresa; Hein, Silvia; Rodrı́guez, Sara; Montecinos, Hernán; Rodríguez, Estéban M.

doi:10.1016/s0169-328x(02)00565-x

Cited by 52 publications

(46 citation statements)

References 30 publications

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“…L-DOPA, the dopamine precursor, is the most abundant among the amines identified in the CSF (Rodríguez et al 1999). Worth mentioning is the finding that the SCO-RF complex is involved in the regulation of the CSF concentration of L-DOPA (Rodríguez et al 1999;Caprile et al 2003). (3) The cells of the choroid plexus, another type of secretory ependyma, have serotonin receptors at the apical membrane (Giordano and Harting 1987).…”

Section: Localization By Immunocytochemistrymentioning

confidence: 99%

“…Although the function of the SCO in adulthood is far from being fully known, the early view that it participates in the clearance of CSF monoamines (Hess and Sterba 1973) has gained strong support from recent investigations (Rodríguez et al 1999;Rodríguez and Caprile 2001;Caprile et al 2003). The elucidation of the mechanisms controlling the secretory activity of the SCO may contribute to the further unfolding of the overall function of this brain gland.…”

Section: Introductionmentioning

confidence: 99%

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The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

Tomé¹,

Jiménez²,

Richter

et al. 2004

Cell Tissue Res

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Dopamine receptors have been found in certain populations of non-neuronal cells in the brain, viz., discrete areas of ciliated ependyma and the ependymal cells of the choroid plexus. We have studied the presence of both tyrosine-hydroxylase-immunoreactive nerve fibers and dopamine receptors in the subcommissural organ (SCO), an ependymal brain gland that is located in the roof of the third ventricle and that secretes, into the cerebrospinal fluid, glycoproteins that aggregate to form Reissner's fiber (RF). Antibodies against D2, D3, D4, and D5 dopamine receptors were used in immunoblots of bovine striatum, fresh SCO, and organ-cultured SCO, and in immunocytochemistry of the bovine, rat, and mouse SCO. Only a few tyrosine-hydroxylase fibers appeared to reach the SCO. However, virtually all the secretory ependymal and hypendymal cells of the SCO immunoreacted with antibodies against D2, D4, and D5 receptors, with the last-mentioned rendering the strongest reaction, especially at the ventricular cell pole of the secretory ependymocytes, suggesting that dopamine might reach the SCO via the cerebrospinal fluid. The antibodies against the four subtypes of receptors revealed corresponding bands in immunoblots of striatum and fresh SCO. Although the cultured SCO displayed dopamine receptors, dopamine had no apparent effect on the expression of the SCO-spondin gene/protein or on the release of RF-glycoproteins (SCO-spondin included) by SCO explants, suggesting that dopamine affects the function(s) of the SCO differently from the secretion of RF-glycoproteins.

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Section: Localization By Immunocytochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

Tomé¹,

Jiménez²,

Richter

et al. 2004

Cell Tissue Res

View full text Add to dashboard Cite

show abstract

“…In the adult human brain, the subcommissural organ and Reissner's fiber can no longer be detected [52], suggesting that the fiber plays a special role during the development of the mammalian CNS [50]. This fiber is composed of aggregated glycoproteins and has the capacity to bind substances present in the CSF and most probably affects the clearance of monoamines from the CSF [53,54]. …”

Section: Introductionmentioning

confidence: 99%

The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review

Veening

Barendregt

2010

Fluids Barriers CNS

137

112

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The cerebrospinal fluid (CSF) system provides nutrients to and removes waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these vary between locations, suggesting they are important for the changes in brain activity that underlie different brain states, and induce different sensory input and behavioral output relationships.The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances contained in the CSF. In this review we discuss the production and flow of the CSF, including the mechanisms involved in the regulation of its composition. In addition, the available evidence for the release of neuropeptides and other neuroactive substances into the CSF is reviewed, with particular attention to the selective effects of these on distant downstream receptive brain areas. As a conclusion we suggest that (1) the flowing CSF is involved in more than just nutrient and waste control, but is also used as a broadcasting system consisting of coordinated messages to a variety of nearby and distant brain areas; (2) this special form of volume transmission underlies changes in behavioral states.

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“…SCO-spondin, a specific glycoprotein, may play a role in neuronal maturation in the developing brain (Gobron et al 1996(Gobron et al , 2000Meiniel 2001). In addition, the insoluble Reissner's fiber, which extends through the ventricular system and the central canal of the spinal cord, has the capacity to bind monoamines and may be involved in CSF neurotransmitter homeostasis (Caprile et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

Somera

Jones

2004

Cell and Tissue Research

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The H-Tx rat has fetal-onset hydrocephalus associated with closure of the cerebral aqueduct and a reduction in the secretory cells of the subcommissural organ (SCO), a circumventricular organ situated in the dorsal wall of the cerebral aqueduct. The objective of this study was to determine the role of the SCO in hydrocephalus pathogenesis. Serial brain sections through aqueduct regions containing the SCO from H-Tx rats, together with non-hydrocephalic Fischer F344 rats, were studied at E16, before hydrocephalus onset, at E17, the beginning of onset, and at P0 when the hydrocephalus was overt. Tissues were immunostained by AFRU, an antibody against the SCO glycoprotein, and for the intermediate filament nestin. The area of SCO cells with AFRU immunostaining and the severity of lateral ventricle dilatation were quantified by image analysis. At E16 all fetuses had distinct SCO ependymal cells, open aqueducts and normal lateral ventricles. The H-Tx fetuses fell into two groups with large areas and small areas of AFRU immunoreactivity, all with a full complement of SCO cells. By E17, fetuses with small areas of immunoreactivity had reduced numbers of tall SCO secretory cells, and most had aqueducts closed posteriorly and dilated ventricles. Three additional fetuses with small areas of immunoreactivity had narrow but patent aqueducts and normal ventricles, and another had an open aqueduct and dilated ventricles. At P0, pups previously identified as hydrocephalic had small areas of AFRU immunoreactivity, an aqueduct that was closed anteriorly but open posteriorly, ventricular dilatation, and an absence of SCO secretory cells. The aqueduct even when closed was lined by typical ependymal cells throughout. Decreased nestin immunostaining accompanied the SCO changes. It is concluded that reduced SCO glycoprotein immunoreactivity precedes both aqueduct closure and expansion of the lateral ventricles in the H-Tx rat.

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Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid

Cited by 52 publications

References 30 publications

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

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