Reirradiation of Recurrent Pediatric Brain Tumors after Initial Proton Therapy

Neurocognitive Effects and Necrosis in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review

“…More specifically, approximately 3300 new benign or malignant primary CNS tumors are diagnosed annually in patients younger than age 16 years in the United States, and in this age group, brain tumors are the most common solid tumor indication for RT. Many of these patients require large-field radiation such as craniospinal irradiation (CSI) and/or focal RT (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60).…”

“…[49][50][51][52] Reirradiation is being increasingly used as definitive management of locally recurrent disease despite the increased risk of brain necrosis; however, specific reirradiation guidelines are lacking. [53][54][55][56]…”