Reinvestigation of a physiological eluate of the 52Fe/52mMn generator

Proton-induced reactions on Fe, Cu, and Ti from threshold to 55 MeV

“…It is important to note that the Fe(p,x) route provides ≥60% feeding of 52g Mn (t 1/2 = 5.591 ± 0.003 d [8]), implying that the short-lived 52m Mn (t 1/2 = 21.1 ± 0.2 m [8]) can be easily separated through the difference in half-life, to avoid the hard 1434 keV gamma-ray produced by the isomer. However, if nearly pure 52m Mn is desired for preclinical imaging applications, the feeding of 52 Mn through the decay of 52 Fe (t 1/2 = 8.725 ± 0.008 h [8]) exclusively populates the isomer, making this potentially suitable for production through "milking" of a 52 Fe generator [71].…”

Proton-induced reactions on Fe, Cu, & Ti from threshold to 55 MeV

“…For (p,x) reactions on nat Cu, the (p,x) cross sections for 54 Mn, 57 Ni, 57,60,61 Co, and 60,61,64 Cu were extracted, presented in Table II. For (p,x) reactions on nat Ti, the (p,x) cross sections for 43 K and 44g,44m, 44,47,48 Sc were extracted, presented in Table III. In addition, as there exist a number of isomers with radioactive ground states in these mass regions, independent measurements of isomer-to-ground-state branching ratios for nat Fe(p,x) 52m/g Mn, nat Fe(p,x) 58m/g Co, and nat Ti(p,x) 44m/g Sc were extracted and are presented in Table IV isomer branching ratios with literature data (retrieved from EXFOR [44]) are seen in the figures of Appendices B and C. The propagated uncertainty in these cross sections varies widely based on the reaction product in question, with the major components arising from uncertainty in EoB activity (±3-10%), proton fluence (±5-13%), and foil areal density (±0.1-0.3%).…”

“…Proton/Neutron Optical Model Alpha Optical Model E1 γSF Model EMPIRE-3.2.3 [72] Koning-Delaroche [73] Avrigeanu(2009) [74] Modified Lorentzian[75] TALYS-1.8 [76] Koning-Delaroche Specific folded potential [76] Brink-Axel Lorentzian[76] CoH-3.5.3 [77,78] Koning-Delaroche Avrigeanu(1994) [79] Generalized Lorentzian[77, 78] ALICE-2017 [80] Nadasen [81] Parabolic Diffuse-Well [82] Berman-Fultz Lorentzian [83] this potentially suitable for production through "milking" of a 52 Fe generator [47]. Clearly, the use of Fe(p,x) 51,52 Mn has significant untapped potential, and additional work is needed to further characterize these reaction channels for E p ≤60 MeV.…”

Kinetic Modeling of 52Fe/52mMn‐Citrate at tthe Blood‐Brain Barrier by Positron Emission Tomography

“…According to our aim to use both 52 Fe and 52m Mn, the resulting sample was split into two aliquots; both were evaporated to dryness, and after dissolving one part in 7 ml of a 0.07 M citrate buffer (pH 5.8), the 52 Fe/ 52m Mncitrate solution was ready for injection. The second aliquot was dissolved in 6 ml of 2 mM tartaric acid and loaded on a 52m Mn generator (MAP Medical Technologies, Oy, Finland) prepared according to the method of Bläuenstein et al, 1997). After a 15-min incubation unbound metal ions were washed from the generator column with water.…”