Reintroduction of foot-and-mouth disease in Argentina: characterisation of the isolates and development of tools for the control and eradication of the disease

Mattion, Nora; König, Guido; Seki, Cristina; Smitsaart, Eliana; Maradei, Eduardo; Robiolo, Blanca; Duffy, Sergio; León, Elizabeth; Piccone, María E.; Sadir, A.M.; Bottini, Rodolfo; Cosentino, B.; Falczuk, A.; Maresca, Ricardo; Periolo, Osvaldo; Bellinzoni, Rodolfo; Espinoza, Ana Maria; Torre, J.L. La; Palma, Eduardo L.

doi:10.1016/j.vaccine.2004.06.040

Cited by 88 publications

(60 citation statements)

References 16 publications

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“…In countries and areas where FMD vaccination is implemented, the serological differential diagnosis of FMD can be difficult because vaccinated animals cannot be distinguished from infected animals simply by the VNT, since neutralizing antibodies are elicited by vaccination, natural infection or both. Several countries that vaccinate against FMD now use antibodies against NSP of FMDV as replaced serological markers for identifying FMDV-infected animals [9,26]. Developing novel serological methods or improving the currently available ones, especially ELISA, is a crucial step toward the eradication of FMD [1,13,25,35].…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Foot-and-Mouth Disease-Infected Pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA

Chen

Lee

Lin

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. The presence of serum antibodies for nonstructural proteins of the foot-and-mouth disease virus (FMDV) can differentiate FMDV-infected animals from vaccinated animals. In this study, a sandwich ELISA was developed for rapid detection of the foot-andmouth disease (FMD) antibodies; it was based on an Escherichia coli-expressed, highly conserved region of the 3ABC nonstructural protein of the FMDV O/TW/99 strain and a monoclonal antibody derived from the expressed protein. The diagnostic sensitivity of the assay was 98.4%, and the diagnostic specificity was 100% for naïve and vaccinated pigs; the detection ability of the assay was comparable those of the PrioCHECK and UBI kits. There was 97.5, 93.4 and 66.6% agreement between the results obtained from our ELISA and those obtained from the PrioCHECK, UBI and CHEKIT kits, respectively. The kappa statistics were 0.95, 0.87 and 0.37, respectively. Moreover, antibodies for nonstructural proteins of the serotypes A, C, Asia 1, SAT 1, SAT 2 and SAT 3 were also detected in bovine sera. Furthermore, the absence of cross-reactions generated by different antibody titers against the swine vesicular disease virus and vesicular stomatitis virus (VSV) was also highlighted in this assay's specificity.KEY WORDS: antibody detection, foot-and-mouth disease, non-structural protein, sandwich ELISA.

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Section: Discussionmentioning

confidence: 99%

Differentiation of Foot-and-Mouth Disease-Infected Pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA

Chen

Lee

Lin

et al. 2011

The Journal of Veterinary Medical Science

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“…Antibodies against BTV were detected using a commercial immunodiffusion (BTID) test (Veterinary Diagnostic Technology, Inc., Wheat Ridge, Colorado, USA). A blocking ELISA was used for detection of Ab to FMDV, using the Argentinean isolates O1 Caseros (Mattion et al, 2004). Antibodies against EHV-1 were detected by SN (OIE, 2008), using the Kentucky reference strain.…”

mentioning

confidence: 99%

Antibodies to Pathogenic Livestock Viruses in a Wild Vicuñe;a (Vicugna vicugna) Population in the Argentinean Andean Altiplano

Marcoppido

Parreño

Vilá

2010

Journal of Wildlife Diseases

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“…82,89,90 However, routine heterologous challenge studies are rarely performed, as this is time consuming, requires access to expensive bio-containment facilities, and raises serious animal welfare issues when large numbers of animals need to be vaccinated and challenged. If small groups of animals are used, these challenge studies can suffer from low precision.…”

Section: Vaccine Matching: the Selection Of Vaccine Strains For Specimentioning

confidence: 99%

“…92 In order for the expected percentage of protection method to be effective, the vaccine needs to be extensively tested in many (hundreds) cattle by previous challenge tests with homologous virus. 92 Although this method has been widely used in South America, 90,93 the availability of good datasets and sera and the need for diverse vaccine strains are limiting factors for use of this approach in the African context. Therefore, in vitro alternatives to measure cross-reaction between sera elicited by a vaccine and a particular field/ outbreak isolate is recommended, supporting the need to accurately predict vaccine matching without the involvement of animals.…”

Section: Vaccine Matching: the Selection Of Vaccine Strains For Specimentioning

confidence: 99%

“…94 Traditionally, antigenic characterization of a field or outbreak virus is performed indirectly using the in vitro virus neutralization test (VNT), which measures the ability of sera from vaccinated animals to cross-react with the field virus. 61,82,89,90 The neutralization titers are used to calculate r 1 -values to determine antigenic relationships. 95 However, interpretation of the test is plagued by limitations, including the uncertainty as to how well the in vitro matching data actually correlates to in vivo cross-protection, the impact of vaccine potency on protection, and the availability of reference reagents.…”

Section: Vaccine Matching: the Selection Of Vaccine Strains For Specimentioning

confidence: 99%

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Challenges and prospects for the control of foot-and-mouth disease: an African perspective

Maree¹,

Kasanga²,

Scott³

et al. 2014

VMRR

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Abstract:The epidemiology of foot-and-mouth disease (FMD) in Africa is unique in the sense that six of the seven serotypes of FMD viruses (Southern African Territories [SAT] 1, SAT2, SAT3, A, O, and C), with the exception of Asia-1, have occurred in the last decade. Due to underreporting of FMD, the current strains circulating throughout sub-Saharan Africa are in many cases unknown. For SAT1, SAT2, and serotype A viruses, the genetic diversity is reflected in antigenic variation, and indications are that vaccine strains may be needed for each topotype. This has serious implications for control using vaccines and for choice of strains to include in regional antigen banks. The epidemiology is further complicated by the fact that SAT1, SAT2, and SAT3 viruses are maintained and spread by wildlife, persistently infecting African buffalo in particular. Although the precise mechanism of transmission of FMD from buffalo to cattle is not well understood, it is facilitated by direct contact between these two species.Once cattle are infected they may maintain SAT infections without the further involvement of buffalo. No single strategy for control of FMD in Africa is applicable. Decision on the most effective regional control strategy should focus on an ecosystem approach, identification of primary endemic areas, animal husbandry practices, climate, and animal movement. Within each ecosystem, human behavior could be integrated in disease control planning. Different regions in sub-Saharan Africa are at different developmental stages and are thus facing unique challenges and priorities in terms of veterinary disease control. Many science-based options targeting improved vaccinology, diagnostics, and other control measures have been described. This review therefore aims to emphasize, on one hand, the progress that has been achieved in the development of new technologies, including research towards improved tailored vaccines, appropriate vaccine strain selection, vaccine potency, and diagnostics, and how it relates to the conditions in Africa. On the other hand, we focus on the unique epidemiological, ecological, livestock farming and marketing, socioeconomic, and governance issues that constrain effective FMD control. Any such new technologies should have the availability of safe livestock products for trade as the ultimate goal.

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Reintroduction of foot-and-mouth disease in Argentina: characterisation of the isolates and development of tools for the control and eradication of the disease

Cited by 88 publications

References 16 publications

Differentiation of Foot-and-Mouth Disease-Infected Pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA

Differentiation of Foot-and-Mouth Disease-Infected Pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA

Antibodies to Pathogenic Livestock Viruses in a Wild Vicuñe;a (Vicugna vicugna) Population in the Argentinean Andean Altiplano

Challenges and prospects for the control of foot-and-mouth disease: an African perspective

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