Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats

Walker, Richard F.

doi:10.1016/0197-4580(82)90048-3

Cited by 17 publications

(2 citation statements)

References 22 publications

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“…These effects are presumably mediated by an impact of the steroid on the brain, where altered metabolism of hypothalamic monoamines and degeneration of neurons in the arcuate nucleus follow administration of estrogen (21,22). Pharmacodynamic changes include alterations in the metabolism of serotonin (22), whose intermittent metabolism and secretion has been linked to phasic secretion of LH (23,24). Estrogen abolishes the rhythmic metabolism of brain serotonin, thus perturbing the signal needed for phasic release of LH.…”

Section: Estrogen and Prolactinmentioning

confidence: 99%

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

Walker¹

1986

Environmental Health Perspectives

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Section: Estrogen and Prolactinmentioning

confidence: 99%

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

Walker¹

1986

Environmental Health Perspectives

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Section: Estrogen and Prolactinmentioning

confidence: 99%

Age factors potentiating drug toxicity in the reproductive axis.

Walker¹

1986

Environ Health Perspect

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Traditionally, drug toxicity in the reproductive system has been a concern only as it affects fertility and fecundity in young individuals. The purpose of this report is to address the potential problem of synergy between drug actions and abnormal secretion of reproductive hormones that together produce disease in older individuals. Thus, reproductive toxicity has different, but no less serious implications in aging individuals. During aging, the coordinated function of elements within the reproductive neuroendocrine axis degrades. This change promotes atypical secretion of hormones producing abnormal responses in target organs and thus creates a condition with pathogenic potential. Certain drugs may contribute to reproductive toxicity in aging individuals either by accelerating the process of dysregulation and/or by synergizing with hormones to stimulate pathologic changes in target tissues. The geriatric population of the world is increasing, and since it consumes a proportionately larger percentage of drugs than younger groups, this novel form of reproductive toxicity may represent a problem in drug safety that warrants serious consideration.

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Aging of the Female Reproductive System: A Neuroendocrine Perspective

Wise¹

1989

Neuroendocrine Perspectives

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Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats

Cited by 17 publications

References 22 publications

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

Age factors potentiating drug toxicity in the reproductive axis.

Aging of the Female Reproductive System: A Neuroendocrine Perspective

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