Reinnervation of smooth and striated muscle by sensory nerve fibers.

Vera, Cristián L.; Luco, J. V.

doi:10.1152/jn.1967.30.3.620

Cited by 28 publications

(15 citation statements)

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“…Several models such as motor-to-motor [Zalewski, 1970;Conley and Baker, 1979;Pensak et al, 1986;Angelov et al, 1993;Danziger et al, 1995;Matsunaga et al, 1995;Angelov et al, 1997;Terzis and Noah, 1997], visceral sensory-to-postganglionic sympathetic motor [Vera and Luco, 1967], visceral sensory-to-somatic motor [Rousseau, 1984] and preganglionic parasympathetic motor-tosomatic motor [Rousseau, 1984;Flumerfelt et al, 1986;McWilliam et al, 1995;Chang et al, 1998;Lan et al, 2000aLan et al, , 2000bLan et al, , 2003Lan et al, , 2004 nerve cross-coaptations have offered substantial promise in nerve regeneration or even in functional reinnervation. In the latter, McWilliam et al [1995] have provided physiological evidence that some functional restorations could be achieved by VHC in the rat.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Observations on the Progress of Nerve Degeneration and Regeneration at the Suture Site following Vagal-Hypoglossal Nerve Coaptation in Cats

Tyan

Hsu³

et al. 2009

Cells Tissues Organs

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Nerve degeneration and regeneration have been investigated at the suture site following proximal-to-distal vagal-hypoglossal nerve coaptation (VHC) in cats at different time points (from 3 to 315 days postoperatively; dpo). Massive axonal degeneration and myelin breakdown and removal of degraded neural debris were observed during the first 2 weeks postoperatively. This was followed by active Schwann cell multiplication and inflammatory cell invasion at 14 dpo. Schwann cells appeared mobile, and were guided to the newly developed growth cones, dividing them into axonal sprout clusters. At 18 dpo, the migrating Schwann cells were confined to the preexisting basal lamina scaffolds, forming bands of Büngner. It is suggested that the latter may play a key role in navigating the regenerating axons to their newly acquired target organ at 22 dpo. Remyelination of axons was not observed till 46 dpo. Compared with the rapid axonal reaction in other models of nerve injury, the degeneration process in VHC was protracted and, furthermore, regeneration and remyelination were delayed. The subtle remodeling of the nerve in cross-coaptation may be far greater than previously recognized, and this may have clinical importance since patients undergoing nerve crossover microsurgery exhibit delayed motor rehabilitation, apparently as a direct result of a change in target innervation. Defining the mechanisms underlying the neuroplastic program could thus potentially improve the prognosis of crossover of two different peripheral nerves.

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Section: Discussionmentioning

confidence: 99%

Ultrastructural Observations on the Progress of Nerve Degeneration and Regeneration at the Suture Site following Vagal-Hypoglossal Nerve Coaptation in Cats

Tyan

Hsu³

et al. 2009

Cells Tissues Organs

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“…In addition, there have been reports of successful, apparently cholinergic, reinnervation by nerves whose normal transmitter is unknown, such as the central ends of spinal sensory nerves (Weiss, 1935) and the central ends of vagal sensory afferents (Vera & Luco, 1967).…”

Section: Introductionmentioning

confidence: 99%

The physiology, pharmacology, and trophic effectiveness of synapses formed by autonomic preganglionic nerves on frog skeletal muscle.

Grinnell¹,

Rheuben²

1979

The Journal of Physiology

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“…Specific neural influences have been better demonstrated by re-innervating various skeletal muscles with foreign nerves (Buller & Lewis, 1965; Dubowitz, 1967;Hnik, Jirmanova', Vyklicky & Zelena', 1967;Miledi, Stefani & Zelena, 1968;Miledi & Stefani, 1969;Buller & Mommaerts, 1969). It is known that nerves other than somatic motor may innervate skeletal muscle (Langley & Anderson, 1904;Vera & Luco, 1967), but the properties of these re-innervated muscle fibres and their nerve-muscle junctions have not been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Contractile and electrical responses of vagus‐innervated frog sartorius muscles

Landmesser¹

1971

The Journal of Physiology

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SUMMARY1. Frog sartorius muscles were transplanted to the thoracic region and re-innervated by the gastric vagus nerve. Contractile responses of the re-innervated muscles were studied. Micro-electrodes were used to measure electrical properties of the muscle fibre membrane. Histological studies of the sartorius and vagus nerves and re-innervated muscles were also carried out.2. Autonomic nerve fibres of the gastric vagus form functional connexions with the skeletal muscle fibres. Such vagus-innervated muscle fibres do not atrophy.3. Neither the contractile nor the passive electrical properties of the muscle fibres are altered by vagal innervation.4. Synaptic transmission is quantal in nature and describable by a Poisson distribution as at normal sartorius junctions. The muscle fibres, however, do show extensive multiple-innervation, and unlike normal sartorius junctions, vagus-muscle junctions have a low quantal content and show a long-lasting facilitation.5. Properties of the vagus nerve fibres apparently are not altered by synapsing with skeletal muscle fibres. They remain small diameter and have high threshold for electrical stimulation.6. The ability of these nerve and muscle fibres to influence each other is rather limited in the adult amphibian.

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Reinnervation of smooth and striated muscle by sensory nerve fibers.

Cited by 28 publications

References 0 publications

Ultrastructural Observations on the Progress of Nerve Degeneration and Regeneration at the Suture Site following Vagal-Hypoglossal Nerve Coaptation in Cats

Ultrastructural Observations on the Progress of Nerve Degeneration and Regeneration at the Suture Site following Vagal-Hypoglossal Nerve Coaptation in Cats

The physiology, pharmacology, and trophic effectiveness of synapses formed by autonomic preganglionic nerves on frog skeletal muscle.

Contractile and electrical responses of vagus‐innervated frog sartorius muscles

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