Reinke's Edema

Tavaluc, Raluca; Tan-Geller, Melin

doi:10.1016/j.otc.2019.03.006

Cited by 44 publications

(57 citation statements)

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“…Reinke ödemi; kord vokallerin benign, diffüz polipoid dejenerasyonu ile karakterize hastalığıdır. Polipoid kordit, polipoid larenjit, polipoid dejenerasyon, sigara polibi ve kronik hipertrofik larenjit, olarak da adlandırılır (1). Vokal kordlar; epitel lamina propria ve kas tabakasından oluşur.…”

Section: Introductionunclassified

“…Reinke ödemi bu boşluğun jelatinöz-müsinöz sıvı ile dolması ile meydana gelir. Bu sıvı vokal kordların kitlesini artırır ve ses perdesinin değişmesine sebep olur (1,2). İlerleyen dönemlerde jelatinöz-müsinöz sıvı yerini fibröz dokuya bırakır ve vokal kordlarda polipoid dejenerasyon görülür (3).…”

Section: Introductionunclassified

“…İlerleyen dönemlerde jelatinöz-müsinöz sıvı yerini fibröz dokuya bırakır ve vokal kordlarda polipoid dejenerasyon görülür (3). Sesin kötü kullanımı, sigara ve reflü reinke ödemi için önemli üç etiyolojik faktördür (1). Hipotiroidi de etiyolojik faktör olarak suçlansada bu konuda tam bir görüş birliği yoktur (4).…”

Section: Introductionunclassified

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Bilateral Reinke Ödemi Cerrahisi Sonrası Ses Kalitesinin Akustik Analiz ile Değerlendirilmesi:

Yilmaz¹,

Afyoncu²,

Ensari³

et al. 2021

Akdeniz Medical Journal

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Section: Introductionunclassified

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Bilateral Reinke Ödemi Cerrahisi Sonrası Ses Kalitesinin Akustik Analiz ile Değerlendirilmesi:

Yilmaz¹,

Afyoncu²,

Ensari³

et al. 2021

Akdeniz Medical Journal

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“…Reinke's oedema (RE) is benign diffuse swelling of the vocal folds, also known as various polyploid degeneration and smoker's polyps. These lesions can be unliteral as well as bilateral [1]. The general population prevalence of Reinke's oedema is 3,47/1000 [2].…”

Section: Introductionmentioning

confidence: 99%

Distribution and Appearance of Ki-67, IL-1α, IL-10 and PGP 9.5 in Reinke’s Oedema-affected Larynx Tissue Compared With Control Tissue

Konopecka

Pilmane

Sumerags

et al. 2020

Preprint

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Background: Reinke’s oedema (benign diffuse swelling of the vocal folds) induced various morphological changes occurs in the superficial lamina propria also known as the Reinke’s space. Smoking, laryngopharyngeal reflux and vocal fold abuse can promote the development of this condition as well as lead to vocal fold dysfunction and injury. Patients with Reinke’s oedema complain of vocal problems. 3,47/1000 is estimation of the general population prevalence of Reinke’s oedema. Investigation of the distribution and appearance of Ki-67, IL-1α, IL-10 and PGP 9.5 in Reinke’s oedema-affected larynx tissue compared with control tissue was the aim of the work.Methods: Routine histological and immunohistochemical analysis were applied for specimens with Reinke’s oedema and the control group. Biotin-streptavidin biochemical method was used for detection of Ki-67, PGP 9,5, IL-10 and IL-1α. Immunoreactive cells appearance local distribution were evaluated using semiquantitative grading method. Statistical analysis of the data was performed using nonparametric statistical methods (Mann Whitney U test and Spearman’s rank coefficient).Results: A high positive correlation was found between IL-1α and PGP 9.5 epithelial immunoreactive cells and between epithelial and subepithelial IL-10 cells in the control group. Mann-Whitney U tests revealed significant differences in immunoreactive markers between the patients and the control group. With exception of PGP 9.5 positive subepithelial nerves, all other examined markers revelated higher number of immunoreactive positive structures in the patient tissue.Conclusions: Intensive proliferation of the surface epithelium was observed in Reinke’s oedema affected larynx tissue. Increased expression of IL-1 α structures is linked to tissue remodulation, inflammation and remodulation. Notable increase in IL-10 positive structures is indicating to the dominant anti-inflammatory tissue response. PGP 9.5 expression increase is involved in the morphopathogenesis of Reinke’s oedema.Trial registration: This study was approved by the Ethical Committee of Riga Stradins University, issued on 31-10-2019, No 6-2/2/25.

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“…Reinke's oedema is a degeneration of one or both vocal folds within Reinke's space. 1 It is still debated whether the thyroid function, among the causes of Reinke's edema, can play a role of some kind. We aim to propose a clinical case report discussing the possible implications of endocrine therapy for this condition.…”

Section: Introductionmentioning

confidence: 99%

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Reinke's Edema

Cited by 44 publications

References 45 publications

Bilateral Reinke Ödemi Cerrahisi Sonrası Ses Kalitesinin Akustik Analiz ile Değerlendirilmesi:

Bilateral Reinke Ödemi Cerrahisi Sonrası Ses Kalitesinin Akustik Analiz ile Değerlendirilmesi:

Distribution and Appearance of Ki-67, IL-1α, IL-10 and PGP 9.5 in Reinke’s Oedema-affected Larynx Tissue Compared With Control Tissue

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