Reinforcing effects of triazolam in sedative abusers: Correlation of drug liking and self-administration measures

Roache, John D.; Meisch, Richard A.; Henningfield, Jack E.; Jaffe, Jerome H.; Klein, S.; Sampson, Annie

doi:10.1016/0091-3057(94)00281-m

Cited by 27 publications

(11 citation statements)

References 13 publications

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“…A second, more important problem is the verbal report format for assessing preference. Although verbal reports of liking and preferences are usually a good indicator of subjects' drug preference behavior in other procedures (29, 30), it is possible that the subjects behavior, if they were given the option to spend time in the two rooms, would yield different results. Physiological measures e.g., heart rate, may also be a more sensitive indicator of preference in a test involving re-exposure to the two rooms.…”

Section: Discussionmentioning

confidence: 99%

Amphetamine-Induced Place Preference in Humans

Childs

Wit

2009

Biological Psychiatry

106

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Background-The conditioned place preference procedure is a widely used animal model of rewarding drug effects that, to date, has not been tested in humans. In this study, we sought to demonstrate that humans, like non-humans, would exhibit a preference for a place previously associated with amphetamine. Further, we investigated the relationship between conditioned place preference and the mood-altering effects of the drug.

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Section: Discussionmentioning

confidence: 99%

Amphetamine-Induced Place Preference in Humans

Childs

Wit

2009

Biological Psychiatry

106

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“…These studies have not been summarized in the Table because they did not provide interpretable information about drug reinforcement: they lacked a placebo control and results were not replicated across the two studies& / t b l . b (Roache and Griffiths 1989;Silverman et al 1994;Roache et al 1995). Variations in dose have shown that higher benzodiazepine doses are usually associated with greater reinforcing effects than lower doses (Griffiths et al , 1979(Griffiths et al , 1984bMumford et al 1995a,b).…”

Section: Reinforcing Effects Of Benzodiazepines In Humansmentioning

confidence: 94%

Benzodiazepine self-administration in humans and laboratory animals - implications for problems of long-term use and abuse

1997

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Drug reinforcement may represent the primary behavioral-pharmacological mechanism underlying two types of problematic use of benzodiazepines--recreational abuse by polydrug abusers and inappropriate chronic use by patients. High dose polydrug abuse for the purpose of getting high is readily recognized as a significant social problem. Inappropriate chronic benzodiazepine use is more subtle but relatively common: for anxiolytics, 36% of past-year users (3% of the adult population in the US) report using these drugs for 4 consecutive months or longer. The risks of such long-term use are much better documented than the benefits. This paper provides a current review of various problems that have been identified with the long-term use and the recreational abuse of benzodiazepines, including memory impairment, risk of accidents, falls and hip fractures in the elderly, a withdrawal syndrome, brain damage, overuse in the elderly, overuse by chronic pain patients, overuse by alcoholics and recreational abuse among alcoholics and polydrug abusers. A comprehensive review of the literature on benzodiazepine reinforcing effects in humans and laboratory animals is also provided. Drug self-administration studies in humans and laboratory animals provide models of both types of problematic benzodiazepine use. Recreational abuse of benzodiazepines has been modeled in human research with polydrug abusers and in laboratory animal studies, which show that the reinforcing effect of benzodiazepines is intermediate relative to other sedative compounds and is increased in subjects with histories of previous sedative drug self-administration. The problem of inappropriate long-term use of benzodiazepines by people without histories of drug abuse has been partially modeled in human studies showing that benzodiazepines function as reinforcers in subjects with anxiety, insomnia, and histories of moderate alcohol consumption, and in preclinical studies showing stable, low-rate benzodiazepine self-injection with concurrent physical dependence under conditions of continuous availability. Both human and animal research suggests that the drug history and current behavioral context may be important in the establishment of benzodiazepines as reinforcers. Limited human and animal research provides little support for the common belief that physical dependence enhances benzodiazepine reinforcement.

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“…At 16:30 hours (6 h post-methamphetamine dose), subjects were asked to express their feelings about the effects of the methamphetamine they received earlier in the day (Roache and Meisch, 1995 ;Roache et al, 1995a). In response to the statement 'I would use this methamphetamine dose again ', they were asked to use a pencil to place a perpendicular mark on a 100-mm line labelled (left to right) 'not at all ' to 'extremely '.…”

Section: End-of-day Questionnaire (Edq)mentioning

confidence: 99%

Effects of acute topiramate dosing on methamphetamine-induced subjective mood

Johnson

Roache

Ait-Daoud

et al. 2006

Int. J. Neuropsychopharm.

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Clinical studies have shown that topiramate, a sulphamate-substituted fructopyranose derivative, might be an efficacious treatment for alcohol dependence, smoking cessation within an alcohol-dependent population, and cocaine dependence. Mechanistically, topiramate's therapeutic effects have been hypothesized to be due to inhibition of cortico-mesolimbic dopamine function, the primary substrate that governs the acquisition, maintenance, and reinstatement of goal-directed behaviour towards seeking abused drugs. Predicated on this hypothesis, we tested in 10 methamphetamine-dependent individuals (three females) whether low- or high-dose (15 or 30 mg i.v.) methamphetamine-induced positive subjective effects and reinforcement can be antagonized by low- or high-dose (100 or 200 mg orally) topiramate using a placebo-controlled, cross-over, factorial design. Methamphetamine administration was associated with orderly, prototypical, and significant increases on measures of stimulation, euphoria, craving, and reinforcement; however, some dysphoric symptoms also emerged. Topiramate alone showed a non-significant trend towards mild reductions in positive mood and reinforcement; yet topiramate appeared to accentuate the appreciation of methamphetamine-induced stimulation and euphoria significantly, but not craving or reinforcement. The experimental combination of topiramate and methamphetamine appeared to be safe and well tolerated, with few adverse events. Acute dosing with up to 200 mg topiramate appears to enhance, rather than attenuate, the positive subjective effects of methamphetamine. Perhaps this indicates a partial inhibition of methamphetamine's reinforcing effects. Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine.

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Reinforcing effects of triazolam in sedative abusers: Correlation of drug liking and self-administration measures

Cited by 27 publications

References 13 publications

Amphetamine-Induced Place Preference in Humans

Amphetamine-Induced Place Preference in Humans

Benzodiazepine self-administration in humans and laboratory animals - implications for problems of long-term use and abuse

Effects of acute topiramate dosing on methamphetamine-induced subjective mood

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