Reinforcing effect for corn oil stimulus was concentration dependent in an operant task in mice

Yoneda, Tomohiro; Taka, Yuichi; Okamura, Maya; Maekawa, Takafumi; Matsumura, Shigenobu; Manabe, Yasuko; Tsuzuki, Satoshi; Inoue, Kazuo; Fushiki, Tohru

doi:10.1016/j.lfs.2007.09.020

Cited by 25 publications

(33 citation statements)

References 53 publications

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“…The rewarding effect was diminished by pretreatment with naloxone (Imaizumi et al 2001), suggesting that corn oil functions as a 'reinforcer' in rodents, possibly though the opioid system (Imaizumi et al , 2001. This reinforcing effect of fat was also demonstrated by the operant test, in which the operant response to corn oil is concentration-dependently enhanced under a progressive ratio schedule (Yoneda et al 2007b). The beta-endorphin knockout mice showed a reduced break point on dietary oil compared with that in the littermate normal mice using the operant behavior test (Hayward et al 2002).…”

Section: Discussionmentioning

confidence: 93%

“…Mice showed strong place preference for dietary oil in the conditioned place preference (CPP) test. Furthermore, ingestion of corn oil induced a strong reinforcing effect in the operant task (Yoneda et al 2007b).…”

Section: Introductionmentioning

confidence: 95%

“…The principle of the apparatus was the same as that described in our previous study (Yoneda et al 2007b). Briefly, the test chambers (32 cm × 22 cm × 10.5 cm) were connected to a standard analogdigital converter (Mac Lab/8 S, ADInstrument, NSW, Australia) through the two cables, respectively.…”

Section: Licking Testmentioning

confidence: 99%

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Preference for dietary fat induced by release of beta-endorphin in rats

et al. 2009

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

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Preference for dietary fat induced by release of beta-endorphin in rats

et al. 2009

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“…The procedure used in the current study was based on earlier reports (19,20) and our previous study (10), with small modifications. Briefly, mice were food-restricted for 5 d to maintain their body weight at 80-90% of their original weight.…”

Section: Methodsmentioning

confidence: 99%

“…We previously demonstrated that, similar to drug administration, fat ingestion can serve as a reinforcer by inducing place preference or strong lever-pressing behavior in mice (we define these as "reinforcing effects") (9,10). Moreover, it has been reported that opioid receptor antagonists can diminish the reinforcing influence of fat (11).…”

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confidence: 97%

Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration

Sakamoto

Matsumura

Okafuji

et al. 2015

J Nutr Sci Vitaminol

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Most animals, including humans, have a high avidity for consuming dietary fat. Previous studies have reported that fat preference can be attributed to many factors, including palatable flavor, texture, and chemical perception. Moreover, transection of nerves associated with either olfaction or gustation (i.e., olfactory or glossopharyngeal nerve) has been shown to decrease fat ingestion (1-3). In the central nervous system, several studies have suggested that the opioid system, canonically associated with reward circuitry, is associated with dietary preferences for fat. We recently reported that fat ingestion induces elevations in the endogenous opioid peptide, beta-endorphin, in cerebrospinal fluid (4). Furthermore, we have also demonstrated that fat ingestion can activate pro-opiomelanocortin (POMC) neurons in the hypothalamus, which synthesize beta-endorphin (5). Many reports have suggested that administration of opioid receptor antagonists can attenuate fat preference, an observation that is consistent with our findings (4,(6)(7)(8).A significant amount of experimental evidence implicates the opioid system in the reward and reinforcement of drug addiction. We previously demonstrated that, similar to drug administration, fat ingestion can serve as a reinforcer by inducing place preference or strong lever-pressing behavior in mice (we define these as "reinforcing effects") (9, 10). Moreover, it has been reported that opioid receptor antagonists can diminish the reinforcing influence of fat (11). These findings suggest that the opioid system contributes not only to fat preference, but also to reinforcement. However, the concentration of fat that produces a reinforcing effect might differ from that inducing preference behavior. Indeed, while mice prefer fat even at low concentrations (12), the reinforcing property of fat is only observed in response to substances with higher fat content (13). These findings indicate that the mechanisms underlying preference for fat are distinctly dependent on fat content. Since POMC neurons regulate energy homeostasis modulating feeding and/or energy expenditure (14-17), the opioid system might have an influence on the preference for high fat concentrations.It also seems likely that several nerves (i.e., the chorda tympani, glossopharyngeal, and trigeminal nerves) are involved in recognizing the presence of dietary fat in the oral cavity. In particular, the glossopharyngeal nerve contributes to preference behavior associated with high concentrations of fat, since glossopharyngeal nerve transection (GLX) can partially inhibit POMC neurons that have been activated by fat ingestion (5). Conversely, olfactory nerve transection (ONX) can abolish the preference for low fat concentrations (18); thus, olfactory and gustatory transduction related to fat preference might rely on fat concentration in a different manner. Summary High-fat foods tend to be palatable and can cause addiction in mice via a reinforcing effect. However, mice showed preference for low fat concentrations that do not...

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