Reinforcing Aerosol Cisplatin for Radiotherapy of Laryngeal Cancer.

Feasibility and effectiveness of inhaled carboplatin in NSCLC patients

“…Drug concentration in the tumor appears to be a key parameter to achieve drug efficacy in humans. These data support the potential value of targeted chemotherapy to lung tumors, as already successfully applied in several cancer settings such as liver metastasis, ovarian tumors, laryngeal cancer, neoplastic meningitis/pericardial effusion or brain tumors [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

“…Paclitaxel and doxorubicin have only been studied in animals; nevertheless, a phase I/II trial with aerosolized doxorubicin in humans is currently completed [32][33][34][35][36]. Cisplatin was firstly applied as an aerosol compound by inhalation for laryngeal cancer in an experimental study [27].…”

Cisplatin Pasting for Radiotherapy of Penile Cancer.

“…But for the history of prior bleomycin therapy, bleomycin pasta could have also been applied to him (Okuyama and Mishina 1992). There are no reports of direct application of cisplatin in solution or pasta or ointment but ours: aerosol (Okuyama et al 1993) and pasta (this paper). Usefulness of topial application of bleomycin ointment has been known: a larger radiation dosage of 50 Gy plus tumorectomy (Fukutani et al 1887) or additional systemic bleomycin and penile amputation (Uchida et al 1992) presumably so as to overcome the probabilistic barrier of cell killing of such treatments.…”